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Søren Lykke-Andersen

Making ends meet: Coordination between RNA 3'end processing and transcription initiation

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RNA polymerase II (RNAPII)-mediated gene transcription initiates at promoters and ends at terminators. Transcription termination is intimately connected to 3'-end processing of the produced RNA and already when loaded at the promoter, RNAPII starts to become configured for this downstream event. Conversely, RNAPII is 'reset' as part of the 3'-end processing/termination event, thus preparing the enzyme for its next round of transcription--possibly on the same gene. There is both direct and circumstantial evidence for preferential recycling of RNAPII from the gene terminator back to its own promoter, which supposedly increases the efficiency of the transcription process under conditions where RNAPII levels are rate limiting. Here, we review differences and commonalities between initiation and 3'-end processing/termination processes on various types of RNAPII transcribed genes. In doing so, we discuss the requirements for efficient 3'-end processing/termination and how these may relate to proper recycling of RNAPII.
Original languageEnglish
JournalWiley Interdisciplinary Reviews: RNA
Pages (from-to)233-246
Number of pages14
Publication statusPublished - 2013

    Research areas

  • Animals, Humans, RNA 3' End Processing, RNA Polymerase II, Transcription Initiation, Genetic

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