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Søren Kragh Moestrup

Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells

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Tumor-associated macrophages (TAMs) represent a distinct malignancy-promoting phenotype suggested to play a key role in tumor formation and metastasis. We aimed to investigate the expression of the monocyte/macrophage-restricted receptor CD163 in bladder tumor biopsies and assess the potential mechanism inducing the CD163 expression in tumor cells. A high CD163 mRNA expression (n = 87) was significantly associated with a poor 13-year overall survival (log-rank test, χ(2) = 8.931; p = 0.0028). Moreover, CD163 mRNA expression was significantly increased in muscle invasive (T2-T4), p = 0.017, and aggressive (grade III/IV) cancers (p = 0.015). The expression strongly correlated with local expression of IL-6 (r = 0.72; p
Original languageEnglish
JournalInternational Journal of Cancer
Volume131
Issue10
Pages (from-to)2320-2331
Number of pages12
ISSN0020-7136
DOIs
Publication statusPublished - 15 Nov 2012

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