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Søren Kragh Moestrup

New immunological serum markers in bacteraemia: anti-inflammatory soluble CD163, but not proinflammatory high mobility group-box 1 protein, is related to prognosis

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  • Department of Medical Biochemistry
  • Clinical Biochemistry
High mobility group-box 1 protein (HMGB1) is a late-onset proinflammatory cytokine. Soluble haemoglobin scavenger receptor (sCD163) is a specific marker of anti-inflammatory macrophages. The study purpose was to relate the levels of these new markers in bactaeremic patients to levels of well-known pro- and anti-inflammatory markers [procalcitonin, lipopolysaccharide (LPS)-binding protein, interleukin (IL)-6, IL-10] and to evaluate the levels in relation to disease severity and aetiology. A total of 110 patients with bacteraemia were included in a prospective manner from the medical department at a large Danish university hospital. Levels of HMGB1 and sCD163 were higher in patients with bacteraemia compared to controls (P < 0.001). HMGB1 correlated with proinflammatory molecules [procalcitonin (PCT)] and traditional infectious parameters [C-reactive proteins (CRP), white blood cells (WBC) and neutrophils], whereas sCD163 correlated with levels of IL-6, IL-10 but not to lipopolysaccharide-binding protein (LBP), PCT or CRP. Levels of sCD163 and IL-6 were significantly higher among non-survivors compared to survivors (P < 0.05). Neither HMGB1 nor any of the proinflammatory markers were elevated in fatal cases compared to survivors. There was no statistically significant difference in HMGB1 and sCD163 levels in Gram-negative versus Gram-positive bacteraemia. HMGB1 reflects proinflammatory processes, whereas sCD163 reflects anti-inflammatory processes as judged by correlations with traditional marker molecules. sCD163 and IL-6, but not HMGB1, were prognostic markers in this cohort pointing to an anti-inflammatory predominance in patients with fatal disease outcome.
Original languageEnglish
JournalClinical and Experimental Immunology
Volume151
Issue3
Pages (from-to)423-31
Number of pages8
ISSN0009-9104
DOIs
Publication statusPublished - 2008

    Research areas

  • Adult, Aged, Aged, 80 and over, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Bacteremia, Biological Markers, Escherichia coli Infections, Female, HMGB1 Protein, Humans, Inflammation Mediators, Male, Middle Aged, Pneumococcal Infections, Prognosis, Prospective Studies, Receptors, Cell Surface, Severity of Illness Index, Staphylococcal Infections, Survival Analysis

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