Søren Kragh Moestrup

Haptoglobin: the hemoglobin detoxifier in plasma

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Haptoglobin : the hemoglobin detoxifier in plasma. / Alayash, Abdu I; Andersen, Christian Brix Folsted; Moestrup, Søren Kragh; Bülow, Leif.

In: Trends in Biotechnology, Vol. 31, No. 1, 01.2013, p. 2-3.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Alayash, AI, Andersen, CBF, Moestrup, SK & Bülow, L 2013, 'Haptoglobin: the hemoglobin detoxifier in plasma', Trends in Biotechnology, vol. 31, no. 1, pp. 2-3. https://doi.org/10.1016/j.tibtech.2012.10.003

APA

CBE

MLA

Alayash, Abdu I et al. "Haptoglobin: the hemoglobin detoxifier in plasma". Trends in Biotechnology. 2013, 31(1). 2-3. https://doi.org/10.1016/j.tibtech.2012.10.003

Vancouver

Author

Alayash, Abdu I ; Andersen, Christian Brix Folsted ; Moestrup, Søren Kragh ; Bülow, Leif. / Haptoglobin : the hemoglobin detoxifier in plasma. In: Trends in Biotechnology. 2013 ; Vol. 31, No. 1. pp. 2-3.

Bibtex

@article{51ad078e4e364c038e69382cee93141a,
title = "Haptoglobin: the hemoglobin detoxifier in plasma",
abstract = "Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered.",
keywords = "Animals, Haptoglobins, Hemoglobins, Hemolysis, Humans, Models, Animal, Oxidative Stress, Plasma, Protein Conformation",
author = "Alayash, {Abdu I} and Andersen, {Christian Brix Folsted} and Moestrup, {S{\o}ren Kragh} and Leif B{\"u}low",
note = "Published by Elsevier Ltd.",
year = "2013",
month = jan,
doi = "10.1016/j.tibtech.2012.10.003",
language = "English",
volume = "31",
pages = "2--3",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Ltd. * Trends Journals",
number = "1",

}

RIS

TY - JOUR

T1 - Haptoglobin

T2 - the hemoglobin detoxifier in plasma

AU - Alayash, Abdu I

AU - Andersen, Christian Brix Folsted

AU - Moestrup, Søren Kragh

AU - Bülow, Leif

N1 - Published by Elsevier Ltd.

PY - 2013/1

Y1 - 2013/1

N2 - Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered.

AB - Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered.

KW - Animals

KW - Haptoglobins

KW - Hemoglobins

KW - Hemolysis

KW - Humans

KW - Models, Animal

KW - Oxidative Stress

KW - Plasma

KW - Protein Conformation

U2 - 10.1016/j.tibtech.2012.10.003

DO - 10.1016/j.tibtech.2012.10.003

M3 - Journal article

C2 - 23140673

VL - 31

SP - 2

EP - 3

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

IS - 1

ER -