Søren Kragh Moestrup

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. / PrabhuDas, Mercy R; Baldwin, Cynthia L; Bollyky, Paul L; Bowdish, Dawn M E; Drickamer, Kurt; Febbraio, Maria; Herz, Joachim; Kobzik, Lester; Krieger, Monty; Loike, John; McVicker, Benita; Means, Terry K; Moestrup, Soren K; Post, Steven R; Sawamura, Tatsuya; Silverstein, Samuel; Speth, Robert C; Telfer, Janice C; Thiele, Geoffrey M; Wang, Xiang-Yang; Wright, Samuel D; El Khoury, Joseph.

In: Journal of Immunology, Vol. 198, No. 10, 15.05.2017, p. 3775-3789.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

PrabhuDas, MR, Baldwin, CL, Bollyky, PL, Bowdish, DME, Drickamer, K, Febbraio, M, Herz, J, Kobzik, L, Krieger, M, Loike, J, McVicker, B, Means, TK, Moestrup, SK, Post, SR, Sawamura, T, Silverstein, S, Speth, RC, Telfer, JC, Thiele, GM, Wang, X-Y, Wright, SD & El Khoury, J 2017, 'A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease', Journal of Immunology, vol. 198, no. 10, pp. 3775-3789. https://doi.org/10.4049/jimmunol.1700373

APA

PrabhuDas, M. R., Baldwin, C. L., Bollyky, P. L., Bowdish, D. M. E., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., McVicker, B., Means, T. K., Moestrup, S. K., Post, S. R., Sawamura, T., Silverstein, S., Speth, R. C., Telfer, J. C., Thiele, G. M., ... El Khoury, J. (2017). A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. Journal of Immunology, 198(10), 3775-3789. https://doi.org/10.4049/jimmunol.1700373

CBE

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang X-Y, Wright SD, El Khoury J. 2017. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. Journal of Immunology. 198(10):3775-3789. https://doi.org/10.4049/jimmunol.1700373

MLA

Vancouver

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M et al. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. Journal of Immunology. 2017 May 15;198(10):3775-3789. https://doi.org/10.4049/jimmunol.1700373

Author

PrabhuDas, Mercy R ; Baldwin, Cynthia L ; Bollyky, Paul L ; Bowdish, Dawn M E ; Drickamer, Kurt ; Febbraio, Maria ; Herz, Joachim ; Kobzik, Lester ; Krieger, Monty ; Loike, John ; McVicker, Benita ; Means, Terry K ; Moestrup, Soren K ; Post, Steven R ; Sawamura, Tatsuya ; Silverstein, Samuel ; Speth, Robert C ; Telfer, Janice C ; Thiele, Geoffrey M ; Wang, Xiang-Yang ; Wright, Samuel D ; El Khoury, Joseph. / A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. In: Journal of Immunology. 2017 ; Vol. 198, No. 10. pp. 3775-3789.

Bibtex

@article{b5fe32ae7bc04ebb99385a5912f66b91,
title = "A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease",
abstract = "Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.",
keywords = "Animals, Endocytosis, Humans, Ligands, Mice, National Institute of Allergy and Infectious Diseases (U.S.), Phagocytosis, Receptors, Immunologic, Receptors, Scavenger, Scavenger Receptors, Class A, Signal Transduction, Terminology as Topic, United States, Consensus Development Conference, NIH, Journal Article",
author = "PrabhuDas, {Mercy R} and Baldwin, {Cynthia L} and Bollyky, {Paul L} and Bowdish, {Dawn M E} and Kurt Drickamer and Maria Febbraio and Joachim Herz and Lester Kobzik and Monty Krieger and John Loike and Benita McVicker and Means, {Terry K} and Moestrup, {Soren K} and Post, {Steven R} and Tatsuya Sawamura and Samuel Silverstein and Speth, {Robert C} and Telfer, {Janice C} and Thiele, {Geoffrey M} and Xiang-Yang Wang and Wright, {Samuel D} and {El Khoury}, Joseph",
note = "Copyright {\textcopyright} 2017 by The American Association of Immunologists, Inc.",
year = "2017",
month = may,
day = "15",
doi = "10.4049/jimmunol.1700373",
language = "English",
volume = "198",
pages = "3775--3789",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "10",

}

RIS

TY - JOUR

T1 - A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

AU - PrabhuDas, Mercy R

AU - Baldwin, Cynthia L

AU - Bollyky, Paul L

AU - Bowdish, Dawn M E

AU - Drickamer, Kurt

AU - Febbraio, Maria

AU - Herz, Joachim

AU - Kobzik, Lester

AU - Krieger, Monty

AU - Loike, John

AU - McVicker, Benita

AU - Means, Terry K

AU - Moestrup, Soren K

AU - Post, Steven R

AU - Sawamura, Tatsuya

AU - Silverstein, Samuel

AU - Speth, Robert C

AU - Telfer, Janice C

AU - Thiele, Geoffrey M

AU - Wang, Xiang-Yang

AU - Wright, Samuel D

AU - El Khoury, Joseph

N1 - Copyright © 2017 by The American Association of Immunologists, Inc.

PY - 2017/5/15

Y1 - 2017/5/15

N2 - Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.

AB - Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.

KW - Animals

KW - Endocytosis

KW - Humans

KW - Ligands

KW - Mice

KW - National Institute of Allergy and Infectious Diseases (U.S.)

KW - Phagocytosis

KW - Receptors, Immunologic

KW - Receptors, Scavenger

KW - Scavenger Receptors, Class A

KW - Signal Transduction

KW - Terminology as Topic

KW - United States

KW - Consensus Development Conference, NIH

KW - Journal Article

U2 - 10.4049/jimmunol.1700373

DO - 10.4049/jimmunol.1700373

M3 - Journal article

C2 - 28483986

VL - 198

SP - 3775

EP - 3789

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 10

ER -