Søren Kragh Moestrup

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Mercy R PrabhuDas, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; mprabhudas@niaid.nih.gov jelkhoury@mgh.harvard.edu.
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  • Cynthia L Baldwin, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003.
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  • Paul L Bollyky, Stanford University
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  • Dawn M E Bowdish, Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, M.G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
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  • Kurt Drickamer, Department of Life Sciences, Imperial College, London SW7 2AZ, United Kingdom.
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  • Maria Febbraio, Department of Dentistry, Katz Group Centre for Pharmacy and Health Research, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
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  • Joachim Herz, Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.
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  • Lester Kobzik, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.
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  • Monty Krieger, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
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  • John Loike, Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
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  • Benita McVicker, University of Nebraska Medical Center, Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105.
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  • Terry K Means, Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
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  • Soren K Moestrup
  • Steven R Post, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205.
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  • Tatsuya Sawamura, Department of Physiology, Research Institute, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
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  • Samuel Silverstein, Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
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  • Robert C Speth, Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL 33328.
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  • Janice C Telfer, Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003.
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  • Geoffrey M Thiele, Division of Rheumatology, Department of Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68105.
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  • Xiang-Yang Wang, Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298.
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  • Samuel D Wright, Cardiovascular Therapeutics, CSL Behring, King of Prussia, PA 19406; and.
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  • Joseph El Khoury, Infectious Disease Division, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129 mprabhudas@niaid.nih.gov jelkhoury@mgh.harvard.edu.

Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.

Original languageEnglish
JournalJournal of Immunology
Volume198
Issue10
Pages (from-to)3775-3789
Number of pages15
ISSN0022-1767
DOIs
Publication statusPublished - 15 May 2017

    Research areas

  • Animals, Endocytosis, Humans, Ligands, Mice, National Institute of Allergy and Infectious Diseases (U.S.), Phagocytosis, Receptors, Immunologic, Receptors, Scavenger, Scavenger Receptors, Class A, Signal Transduction, Terminology as Topic, United States, Consensus Development Conference, NIH, Journal Article

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