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Søren Egedal Degn

Trafficking of B cell antigen in lymph nodes

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  • Santiago F. Gonzalez, Immune Disease Institute, Harvard Medical School
  • ,
  • Søren Egedal Degn
  • Lisa A. Pitcher, Immune Disease Institute, Harvard Medical School
  • ,
  • Matthew Woodruff, Immune Disease Institute, Harvard Medical School
  • ,
  • Balthasar A. Heesters, Utrecht University
  • ,
  • Michael C. Carroll, Immune Disease Institute, Harvard Medical School
  • Department of Medical Microbiology and Immunology
The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.
Translated title of the contributionTransport af B celle antigen i lymfeknuder
Original languageEnglish
JournalAnnual Review of Immunology
Pages (from-to)215-233
Number of pages19
Publication statusPublished - 2011

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