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Søren Egedal Degn

Complement-dependent transport of antigen into B cell follicles

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  • Santiago F. Gonzalez, Immune Disease Institute, Harvard Medical School
  • ,
  • Veronika Lukacs-Kornek, Dana-Farber Cancer Institute
  • ,
  • Michael P. Kuligowski, Immune Disease Institute, Harvard Medical School
  • ,
  • Lisa A. Pitcher, Immune Disease Institute, Harvard Medical School
  • ,
  • Søren Egedal Degn
  • Shannon J. Turley, Dana-Farber Cancer Institute
  • ,
  • Michael C. Carroll, Immune Disease Institute, Harvard Medical School
  • Department of Medical Microbiology and Immunology
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.
Translated title of the contributionKomplement-afhængig transport af antigen til B celle follikler
Original languageEnglish
JournalJournal of Immunology
Pages (from-to)2659-2664
Number of pages6
Publication statusPublished - 2010

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