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Complement-dependent transport of antigen into B cell fol...
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Søren Egedal Degn
Complement-dependent transport of antigen into B cell follicles
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
- Santiago F. Gonzalez, Immune Disease Institute, Harvard Medical School ,
- Veronika Lukacs-Kornek, Dana-Farber Cancer Institute ,
- Michael P. Kuligowski, Immune Disease Institute, Harvard Medical School ,
- Lisa A. Pitcher, Immune Disease Institute, Harvard Medical School ,
- Søren Egedal Degn
- Shannon J. Turley, Dana-Farber Cancer Institute ,
- Michael C. Carroll, Immune Disease Institute, Harvard Medical School
- Department of Medical Microbiology and Immunology
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.
| Translated title of the contribution | Komplement-afhængig transport af antigen til B celle follikler |
|---|---|
| Original language | English |
| Journal | Journal of Immunology |
| Volume | 185 |
| Pages (from-to) | 2659-2664 |
| Number of pages | 6 |
| ISSN | 0022-1767 |
| Publication status | Published - 2010 |
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