The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus. / Voss, Lasse F.; Howarth, Amanda J.; Wittenborn, Thomas R. et al.
In: Frontiers in Immunology, Vol. 13, 1021370, 12.2022.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. / Sirinian, Chaido; Papanastasiou, Anastasios D.; Karayel, Ozge et al.
In: NeoPlasia, Vol. 33, 100836, 11.2022.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. / Fonager, Sofie Vestergaard; Winther, Gudrun; Wittenborn, Thomas Rea et al.
In: Journal of Neuroimmunology, Vol. 370, 577927, 09.2022.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes : Biomolecules. / Brandt, Camilla B.; Fonager, Sofie V.; Haskó, János et al.
2022.Research output: Other contribution › Research
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. / Green, Kenneth; Wittenborn, Thomas R.; Fahlquist-Hagert, Cecilia et al.
In: Frontiers in Immunology, Vol. 12, 782558, 12.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis). / Sirinian, Chaido; Papanastasiou, Anastasios D.; Degn, Soren E. et al.
In: Genes, Vol. 12, No. 11, 1686, 11.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. / Juul-Madsen, Kristian; Troldborg, Anne; Wittenborn, Thomas R et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 30, e2106647118, 07.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras. / Wittenborn, Thomas Rea; Hagert, Cecilia Fahlquist; Ferapontov, Alexey et al.
In: PLOS ONE, Vol. 16, No. 3, e0247501, 03.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
T follicular regulatory cells : Guardians of the germinal centre? / Fahlquist Hagert, Cecilia; Degn, Søren E.
In: Scandinavian Journal of Immunology, Vol. 92, No. 4, e12942, 10.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Seeing the Confetti Colors in a New Light Utilizing Flow Cytometry and Imaging Flow Cytometry. / Hagert, Cecilia Fahlquist; Bohn, Anja Bille; Wittenborn, Thomas R et al.
In: Cytometry. Part A, Vol. 97, No. 8, 2020, p. 811-823.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB. / van der Poel, Cees E.; Bajic, Goran; Macaulay, Charles W. et al.
In: Cell Reports, Vol. 29, No. 9, 2019, p. 2745-2755.e4.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity. / Wittenborn, Thomas R.; Hagert, Cecilia; Degn, Søren E.
In: Journal of visualized experiments : JoVE, No. 146, e59397, 2019.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Clinical and immunological parameters of Sjögren's syndrome. / Psianou, Konstantia; Panagoulias, Ioannis; Papanastasiou, Anastasios D et al.
In: Autoimmunity Reviews, Vol. 17, No. 10, 18.10.2018, p. 1053-1064.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Capturing change in clonal composition amongst single mouse germinal centers. / Firl, Daniel J; Degn, Soren E; Padera, Timothy et al.
In: eLife, Vol. 7, e33051, 01.08.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
B cell tolerance to epidermal ribonuclear-associated neo-autoantigen in vivo. / Degn, Søren Egedal; Alicot, E; Carroll, M.C.
In: Clinical and Experimental Immunology, Vol. 191, No. 2, 02.2018, p. 151-165.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Targeting autoreactive germinal centers to curb autoimmunity. / Degn, Søren Egedal; van der Poel, Cees E.; Carroll, Michael C.
In: OncoTarget, Vol. 8, No. 53, 09.10.2017, p. 90624.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Clonal Evolution of Autoreactive Germinal Centers. / Degn, Søren Egedal; van der Poel, Cees E.; Firl, Daniel J. et al.
In: Cell, Vol. 170, No. 5, 24.08.2017, p. 913-926.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Endogenous Natural Complement Inhibitor Regulates Cardiac Development. / Mortensen, Simon A; Skov, Louise L; Kjaer-Sorensen, Kasper et al.
In: Journal of Immunology, Vol. 198, No. 8, 15.04.2017, p. 3118-3126.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Complement activation, regulation, and molecular basis for complement-related diseases. / Bajic, Goran; Degn, Søren E; Thiel, Steffen et al.
In: E M B O Journal, Vol. 34, No. 22, 21.10.2015, p. 2735-2757.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. / Degn, Søren E; Kjaer, Troels R; Kidmose, Rune Thomas et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 37, 02.09.2014, p. 13445-13450.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function. / Degn, Søren E; Jensenius, Jens C; Thiel, Steffen.
In: Journal of Immunology, Vol. 192, No. 12, 15.06.2014, p. 5447-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner. / Chatterjee, Priyadarshini; Agyemang, Amma F; Alimzhanov, Marat B et al.
In: European Journal of Immunology, Vol. 43, No. 9, 09.2013, p. 2441-50.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. / Degn, Søren E; Jensen, Lisbeth; Olszowski, Tomasz et al.
In: Journal of Immunology, Vol. 191, No. 3, 01.08.2013, p. 1334-45.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Humoral pattern recognition and the complement system. / Degn, S E; Thiel, Steffen.
In: Scandinavian Journal of Immunology, Vol. 78, No. 2, 08.2013, p. 181-93.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Response to comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function". / Degn, Søren E; Jensenius, Jens C; Thiel, Steffen.
In: Journal of Immunology, Vol. 190, No. 6, 15.03.2013, p. 2477-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mitochondria and the lectin pathway of complement. / Brinkmann, Christel R; Jensen, Lisbeth; Dagnaes-Hansen, Frederik et al.
In: Journal of Biological Chemistry, 2013.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor. / Degn, Søren E; Thiel, Steffen; Jensenius, Jens C.
In: Protein Expression and Purification, Vol. 88, No. 2, 2013, p. 173-182.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function. / Degn, Søren Egedal; Jensen, Lisbeth; Hansen, Annette G et al.
In: Journal of Immunology, Vol. 189, No. 8, 2012, p. 3957-69.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules : normal and acute-phase levels in serum and stoichiometry of lectin pathway components. / Thiel, S; Jensen, L; Degn, Søren Egedal et al.
In: Clinical and Experimental Immunology. Supplement, Vol. 169, No. 1, 2012, p. 38-48.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. / Degn, Søren Egedal; Andersen, Stig Henrik; Jensen, Lisbeth et al.
In: Journal of Immunological Methods, Vol. 372, No. 1-2, 2011, p. 204-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Disease-causing mutations in genes of the complement system. / Degn, Søren E; Jensenius, Jens Christian; Thiel, Steffen.
In: American Journal of Human Genetics, Vol. 88, No. 6, 2011, p. 689-705.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
MAp19, the alternative splice product of the MASP2 gene. / Degn, Søren Egedal; Thiel, Steffen; Nielsen, Ole et al.
In: Journal of Immunological Methods, Vol. 373, No. 1-2, 2011, p. 89-101.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Trafficking of B cell antigen in lymph nodes. / Gonzalez, Santiago F.; Degn, Søren Egedal; Pitcher, Lisa A. et al.
In: Annual Review of Immunology, Vol. 29, 2011, p. 215-233.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The lectin pathway and its implications in coagulation, infections and auto-immunity. / Degn, Søren E; Jensenius, Jens C; Bjerre, Mette.
In: Current Opinion in Organ Transplantation, 09.12.2010.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. / Degn, Søren E; Jensen, Lisbeth; Gál, Péter et al.
In: Journal of Immunological Methods, Vol. 361, No. 1-2, 30.09.2010, p. 37-50.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. / Gonzalez, Santiago F.; Lukacs-Kornek, Veronika; Kuligowski, Michael P. et al.
In: Nature Immunology, Vol. 11, No. 5, 05.2010, p. 427-435.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Complement-dependent transport of antigen into B cell follicles. / Gonzalez, Santiago F.; Lukacs-Kornek, Veronika; Kuligowski, Michael P. et al.
In: Journal of Immunology, Vol. 185, 2010, p. 2659-2664.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The Lectin Pathway Serine Proteases and Associated Proteins. / Degn, Søren Egedal.
Århus Universitet, 2010.Research output: Book/anthology/dissertation/report › Ph.D. thesis
MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. / Degn, Søren Egedal; Hansen, Annette; Steffensen, Rudi et al.
In: Journal of Immunology, Vol. 183, No. 11, 2009, p. 7371-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. / Thiel, Steffen; Kolev, Martin; Degn, Søren Egedal et al.
In: Journal of Immunology, Vol. 182, No. 5, 2009, p. 2939-47.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
New perspectives on mannan-binding lectin-mediated complement activation. / Degn, Søren Egedal; Thiel, Steffen; Jensenius, Jens Christian.
In: Immunobiology, Vol. 212, 2007, p. 301-11.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review