Research output per year
Research output per year
- 1 - 50 out of 102 results
Search results
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2025
Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression
Silva, N. R., Arjmand, S., Domingos, L. B., Chaves-Filho, A. M., Mottin, M., Real, C. C., Waszkiewicz, A. L., Gobira, P. H., Ferraro, A. N., Landau, A. M., Andrade, C. H., Müller, H. K., Wegener, G. & Joca, S. R. L., Jan 2025, In: Pharmacological Research. 211, p. 107545 107545.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Neurodegenerative disorders: Advances in neurobiology and new treatment perspectives
Joca, S., Jan 2025, In: Basic and Clinical Pharmacology and Toxicology. 136, 1, e14098.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
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2024
Approaches to embryonic neurodevelopment: from neural cell to neural tube formation through mathematical models
Rafati, A. H., Joca, S., Vontell, R. T., Wegener, G. & Ardalan, M., 1 Jul 2024, In: Briefings in bioinformatics. 25, 4, bbae265.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Bradykinin actions in the central nervous system: Historical overview and psychiatric implications
Graeff, F. G., Joca, S. & Zangrossi, H., 1 Jun 2024, In: Acta Neuropsychiatrica. 36, 3, p. 129-138 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
2 Citations (Scopus) -
Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats
Heisel, L. S., Andersen, F. D., Joca, S., Sørensen, L. K., Simonsen, U., Hasselstrøm, J. B., Andersen, C. U. & Nielsen, K. L., Jan 2024, In: Archives of Toxicology. 98, 1, p. 289-301 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Lægemidler med virkning på noradrenerg neurotransmission og adrenoceptorer
Simonsen, U. & Joca, S., Sept 2024, Basal og Klinisk Farmakologi. Simonsen, U., Dalhoff, K. P., Bergmann, T. & Rosenkilde, M. M. (eds.). 7. udgave ed. København: FADL's Forlag, p. 155-179 24 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect
Guldager, M. B., Biojone, C., Rodrigues Da Silva, N., Dornela Godoy, L. & Joca, S., 13 Jul 2024, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 133, 111029.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access1 Citation (Scopus) -
Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression.
Domingos, L. B., Müller, H. K., da Silva, N. R., Filiou, M. D., Nielsen, A. L., Guimarães, F. S., Wegener, G. & Joca, S., 1 May 2024, In: Neuropharmacology. 248, 109870.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
5 Citations (Scopus) -
Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses
Gobira, P. H., Joca, S. R. & Moreira, F. A., Apr 2024, In: Acta Neuropsychiatrica. 36, 2, p. 67-77 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
5 Citations (Scopus) -
The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex
Sales, A. J., Joca, S. R. L., Del Bel, E. & Guimarães, F. S., 26 Feb 2024, In: Behavioural Brain Research. 458, 114764.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
3 Citations (Scopus) -
Therapeutic potential of cannabidiol in depression
Guldager, M. B., Chaves Filho, A. M., Biojone, C. & Joca, S., Jan 2024, Cannabidiol in Neurology and Psychiatry. London: Academic Press, Vol. 177. p. 251-293 43 p. (International Review of Neurobiology, Vol. 177).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
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The therapeutic potential of cannabidiol in neuropsychiatric and neurodegenerative disorders
Joca, S. & Guimarães, F. S., 1 Oct 2024, In: Acta Neuropsychiatrica. 36, 5, p. 253-254 2 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
1 Citation (Scopus) -
2023
Decreased sensitivity to antidepressant drugs in Wistar Hannover rats submitted to two animal models of depression
Silveira, K. M., Sartim, A. G., Vieira, L., Lisboa, S. F., Wegener, G. & Joca, S. R. L., 14 Feb 2023, In: Acta Neuropsychiatrica. 35, 1, p. 35-49 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Putative role of glial cells in treatment resistance depression: An updated critical literation review and evaluation of single-nuclei transcriptomics data
Sanadgol, N., Miraki Feriz, A., Lisboa, S. F. & Joca, S. R. L., Oct 2023, In: Life Sciences. 331, 122025.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
3 Citations (Scopus) -
Sex and Estrous Cycle Are Not Mediators of S-Ketamine's Rapid-Antidepressant Behavioral Effects in a Genetic Rat Model of Depression
Arjmand, S., Vadstrup Pedersen, M., Silva, N. R., Landau, A. M., Joca, S. & Wegener, G., 1 May 2023, In: The international journal of neuropsychopharmacology. 26, 5, p. 350–358 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access4 Citations (Scopus) -
The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol
Hartmann, A., Vila-Verde, C., Guimarães, F. S., Joca, S. R. & Lisboa, S. F., Feb 2023, In: Current Neuropharmacology. 21, 2, p. 284-308 25 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access11 Citations (Scopus) -
2022
Antipanic-like effect of esketamine and buprenorphine in rats exposed to acute hypoxia
Maraschin, J. C., Frias, A. T., Hernandes, P. M., Batistela, M. F., Martinez, L. M., Joca, S. R. L., Graeff, F. G., Audi, E. A., Spera de Andrade, T. G. C. & Zangrossi, H., Feb 2022, In: Behavioural Brain Research. 418, 113651.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
5 Citations (Scopus) -
Combined effects of quetiapine and opioids: A study of autopsy cases, drug users and sedation in rats
Andersen, F. D., Joca, S., Hvingelby, V., Arjmand, S., Pinilla, E., Comerma Steffensen, S. G., Simonsen, U. & Andersen, C. U., Sept 2022, In: Addiction Biology (Online). 27, 5, e13214.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)53 Downloads (Pure) -
Fluoxetine acts concomitantly on dorsal and ventral hippocampus to Trk-dependently modulate the extinction of fear memory
Diniz, C. R. A. F., da Silva, L. A., Domingos, L. B., Sonego, A. B., Moraes, L. R. B. & Joca, S., Mar 2022, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 113, 110451.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models
Domingos, L. B., Silva, N. R., Chaves Filho, A. J. M., Sales, A. J., Starnawska, A. & Joca, S., Nov 2022, In: Genes. 13, 11, 20 p., 2165.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access11 Citations (Scopus) -
The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder
Mohammad, G. S., Joca, S. & Starnawska, A., Aug 2022, In: Genes. 13, 8, 15 p., 1435.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access6 Citations (Scopus) -
The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants
Arjmand, S., Landau, A. M., Varastehmoradi, B., Andreatini, R., Joca, S. & Wegener, G., Aug 2022, In: Molecular Psychiatry. 27, 8, p. 3138–3149 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
8 Citations (Scopus) -
Tiny in size, big in impact: Extracellular vesicles as modulators of mood, anxiety and neurodevelopmental disorders
Duarte-Silva, E., Oriá, A. C., Mendonça, I. P., de Melo, M. G., Paiva, I. H. R., Maes, M., Joca, S. R. L. & Peixoto, C. A., Apr 2022, In: Neuroscience and Biobehavioral Reviews. 135, 104582.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
12 Citations (Scopus) -
2021
Adolescent cannabinoid exposure modulates the vulnerability to cocaine-induced conditioned place preference and DNMT3a expression in the prefrontal cortex in Swiss mice
Gobira, P. H., Roncalho, A. L., Silva, N. R., Silote, G. P., Sales, A. J. & Joca, S. R., Nov 2021, In: Psychopharmacology. 238, 11, p. 3107-3118 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
5 Citations (Scopus) -
Cannabidiol prevents disruptions in sensorimotor gating induced by psychotomimetic drugs that last for 24-h with probable involvement of epigenetic changes in the ventral striatum
Pedrazzi, J. F. C., Sales, A. J., Guimarães, F. S., Joca, S. R. L., Crippa, J. A. S. & Del Bel, E., Dec 2021, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 111, 9 p., 110352.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
18 Citations (Scopus) -
Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects
Sartim, A. G., Marques, J., Silveira, K. M., Gobira, P. H., Guimarães, F. S., Wegener, G. & Joca, S. R., Sept 2021, In: Neuropharmacology. 195, 108679.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile15 Citations (Scopus)77 Downloads (Pure) -
Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects
Sales, A. J., Maciel, I. S., Suavinha, A. C. D. R. & Joca, S. R. L., Feb 2021, In: Molecular Neurobiology. 58, 2, p. 777–794 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
17 Citations (Scopus) -
Pro-inflammatory cytokines: Potential links between the endocannabinoid system and the kynurenine pathway in depression
Zádor, F., Joca, S., Nagy-Grócz, G., Dvorácskó, S., Szűcs, E., Tömböly, C., Benyhe, S. & Vécsei, L., Jun 2021, In: International Journal of Molecular Sciences . 22, 11, 5903.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access38 Citations (Scopus) -
Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review
Schou, T. M., Joca, S., Wegener, G. & Bay-Richter, C., Oct 2021, In: Brain, Behavior, and Immunity. 97, p. 328-348 21 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile300 Citations (Scopus)208 Downloads (Pure) -
Putative effects of cannabidiol in depression and synaptic plasticity
Joca, S., Silote, G., Sartim, A., Sales, A. J., Guimarães, F. S. & Wegener, G., 2021, The Neuroscience of Depression: Features, Diagnosis and Treatment. Martin, C. R., Hunter, L.-A., Patel, V. B., Preedy, V. R. & Rajendram, R. (eds.). Academic Press, Vol. Part V. p. 459-467 9 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
4 Citations (Scopus) -
Strain-, sex-, and time-dependent antidepressant-like effects of cannabidiol
Silote, G. P., Gatto, M. C., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S. R. L., Dec 2021, In: Pharmaceuticals. 14, 12, 1269.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access24 Citations (Scopus) -
Targeting 2-arachidonoylglycerol signalling in the neurobiology and treatment of depression
Silveira, K. M., Wegener, G. & Joca, S. R. L., Jul 2021, In: Basic & Clinical Pharmacology & Toxicology. 129, 1, p. 3-14 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
16 Citations (Scopus) -
2020
CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim
Sales, A. J., Guimarães, F. S. & Joca, S. R. L., Jun 2020, In: Behavioural Brain Research. 388, 112627.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
41 Citations (Scopus) -
Impaired emotional response to stress in mice lacking galectin-1 or galectin-3
Sartim, A. G., Sartim, M. A., Cummings, R. D., Dias-Baruffi, M. & Joca, S. R., Jun 2020, In: Physiology and Behavior. 220, 112862.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
13 Citations (Scopus) -
Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings
Silote, G. P., de Oliveira, S. F. S., Ribeiro, D. E., Machado, M. S., Andreatini, R., Joca, S. R. L. & Beijamini, V., 8 Jun 2020, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 100, 109878.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
22 Citations (Scopus) -
Orexin A injection into the ventral medial prefrontal cortex induces antidepressant-like effects: Possible involvement of local Orexin-1 and Trk receptors
Stanquini, L. A., Sartim, A. G. & Joca, S. R. L., 1 Oct 2020, In: Behavioural Brain Research. 395, p. 112866 112866.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
9 Citations (Scopus) -
2019
Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine
Ribeiro, D. E., Casarotto, P. C., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E., Zangrossi, H. J., Guimarães, F. S., Joca, S. R. L. & Biojone, C., 2019, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93, July, p. 232-239 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)144 Downloads (Pure) -
Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine
Ribeiro, D. E., Casarotto, P., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E., Zangrossi, H. J., Guimaraes, F. S., Joca, S. & Biojone, C., 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation
Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. & Wegener, G., Nov 2019, In: Journal of Psychopharmacology. 33, 11, p. 1436-1446 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
32 Citations (Scopus) -
Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test
Sartim, A. G., Brito, B. M., Gobira, P. H. & Joca, S. R. L., 1 Feb 2019, In: Behavioural Pharmacology. 30, 1, p. 59-66 8 p., 30(1).Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
11 Citations (Scopus) -
Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
Sales, A. J., Fogaça, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimarães, F. S. & Joca, S. R. L., 1 Feb 2019, In: Molecular Neurobiology. 56, 2, p. 1070–1081 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
147 Citations (Scopus) -
Cannabidiol in mental health disorders
Campos, A. C., Vilela, F., Joca, S. & Guimaraes, F., 2019, Cannabis as Medicine. Wedman-St-Louis, B. (ed.). 1 ed. Boca Raton: CRC Press, p. 79-115 37 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research
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Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors
Diniz, C., Biojone, C., Joca, S., Rantamaki, T., Castren, E., Guimaraes, F. & Casarotto, P., 2019, In: PeerJ. 7, 2, 21 p., e6493.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access16 Citations (Scopus) -
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors
Diniz, C. R. A. F., Biojone, C., Joca, S., Rantamäki, T., Castren, E., Guimaraes, F. S. & Casarotto, P., 2019, In: PeerJ.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Effects of DNA methyltransferase inhibition on pattern separation performance in mice.
Argyrousi, E., Lagatta, D., Schulutter, A., Weidner, M., Zoller, J., van Goethem, N., Joca, S., van den Hove, D. & Prickaerts, J., Mar 2019, In: Neurobiology of Learning and Memory. 159, p. 6-15 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)62 Downloads (Pure) -
Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms
Silote, G. P., Sartim, A., Sales, A., Eskelund, A., Guimarães, F. S., Wegener, G. & Joca, S., Jul 2019, In: Journal of Chemical Neuroanatomy. 98, p. 104-116 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
69 Citations (Scopus) -
Esketamine and Rapastinel, but not Imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression
Pereira, V. S., Joca, S. R. L., Harvey, B. H., Elfving, B. & Wegener, G., 1 Oct 2019, In: Acta Neuropsychiatrica. 31, 5, p. 258-265 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile18 Citations (Scopus)60 Downloads (Pure) -
Nitric oxide signalling and antidepressant action revisited
Joca, S., Sartim, A., Roncalho, A., Diniz, C. & Wegener, G., Jul 2019, In: Cell and Tissue Research. 377, 1, p. 45-58 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile51 Citations (Scopus)77 Downloads (Pure) -
P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G. & Joca, S., 1 Jun 2019, In: International Journal of Molecular Sciences . 20, 11, 2778.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access100 Citations (Scopus) -
Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades
Pereira, V. S., Suavinha, A. C. D. R., Wegener, G. & Joca, S. R. L., Jun 2019, In: Acta Neuropsychiatrica. 31, 3, p. 143-150 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
7 Citations (Scopus)