Sisse Helle Njor

Overdiagnosis in breast cancer screening: The impact of study design and calculations

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Elsebeth Lynge, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK 1014 København K, Denmark. Electronic address: elsebeth@sund.ku.dk.
  • ,
  • Anna-Belle Beau, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK 1014 København K, Denmark.
  • ,
  • Peer Christiansen
  • My von Euler-Chelpin, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK 1014 København K, Denmark.
  • ,
  • Niels Kroman, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK 2100 København K, Denmark.
  • ,
  • Sisse Njor
  • Ilse Vejborg, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Blegdamsvej 9, DK 2100 København K, Denmark.

Overdiagnosis in breast cancer screening is an important issue. A recent study from Denmark concluded that one in three breast cancers diagnosed in screening areas in women aged 50-69 years were overdiagnosed. The purpose of this short communication was to disentangle the study's methodology in order to evaluate the soundness of this conclusion. We found that both the use of absolute differences as opposed to ratios; the sole focus on non-advanced tumours and the crude allocation of tumours and person-years by screening history for women aged 70-84 years, all contributed to the very high estimate of overdiagnosis. Screening affects cohorts of screened women. Danish registers allow very accurate mapping of the fate of every woman. We should be past the phase where studies of overdiagnosis are based on the fixed age groups from routine statistics.

Original languageEnglish
JournalEuropean journal of cancer (Oxford, England : 1990)
Volume80
Pages (from-to)26-29
Number of pages4
ISSN0959-8049
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article

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