Takotsubo-cardiomyopathy is a stress-related acute cardiac disorder characterized by reversible systolic ballooning and hypokinesia of the distal part of the left ventricle, cardiac symptoms, and ECG-changes, but no coronary artery stenosis, and no other causable disease. In the present case, heart disease was suspected because of tachycardia and dyspnoea which continued after treatment for severe asthma. A mural thrombosis was an extraordinary finding in this otherwise typical case.