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Coagulation Profile after Spontaneous Intracerebral Hemorrhage : A Cohort Study. / Lauridsen, Signe Voigt; Hvas, Anne-Mette; Sandgaard, Emilie et al.
In: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 27, No. 11, 2018, p. 2951-2961.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Coagulation Profile after Spontaneous Intracerebral Hemorrhage
T2 - A Cohort Study
AU - Lauridsen, Signe Voigt
AU - Hvas, Anne-Mette
AU - Sandgaard, Emilie
AU - Gyldenholm, Tua
AU - Rahbek, Christian
AU - Hjort, Niels
AU - Tønnesen, Else Kirstine
AU - Hvas, Christine Lodberg
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2018
Y1 - 2018
N2 - Background: Intracerebral hemorrhage (ICH) causes death or disability and the incidence increases with age. Knowledge of acute hemostatic function in patients with ICH without anticoagulant and antiplatelet therapy is sparse. Increased knowledge of the coagulation profile in the acute phase of ICH could improve acute treatment and recovery. We investigated coagulation at admission and changes in coagulation during the first 24 hours after symptom onset. Methods: Enrolled were 41 ICH patients without anticoagulant or antiplatelet therapy admitted to Aarhus University Hospital, Denmark. Blood samples were collected at admission, 6, and 24 hours after symptom onset. Thromboelastometry (ROTEM), thrombin generation, and thrombin-antithrombin (TAT) complex were analyzed. Clinical outcome was evaluated using the National Institute of Health Stroke Scale, the Modified Rankin Score, and mortality. Results: At admission, compared with healthy individuals, ICH patients had increased maximum clot firmness (EXTEM P <.0001; INTEM P <.0001; FIBTEM P <.0001), increased platelet maximum clot elasticity (P <.0001) in ROTEM, higher peak thrombin (P <.0001) and endogenous thrombin potential (P =.01) in thrombin generation, and elevated TAT complex levels. During 24 hours after significantly, while thrombin generation showed decreased peak thrombin (P <.0001) and endogenous thrombin potential (P <.0001). Coagulation test results did not differ between patients when stratified according to clinical outcome. Conclusions: ICH patients without anticoagulant or antiplatelet therapy demonstrated activated coagulation at admission and within 24 hours after symptom onset.
AB - Background: Intracerebral hemorrhage (ICH) causes death or disability and the incidence increases with age. Knowledge of acute hemostatic function in patients with ICH without anticoagulant and antiplatelet therapy is sparse. Increased knowledge of the coagulation profile in the acute phase of ICH could improve acute treatment and recovery. We investigated coagulation at admission and changes in coagulation during the first 24 hours after symptom onset. Methods: Enrolled were 41 ICH patients without anticoagulant or antiplatelet therapy admitted to Aarhus University Hospital, Denmark. Blood samples were collected at admission, 6, and 24 hours after symptom onset. Thromboelastometry (ROTEM), thrombin generation, and thrombin-antithrombin (TAT) complex were analyzed. Clinical outcome was evaluated using the National Institute of Health Stroke Scale, the Modified Rankin Score, and mortality. Results: At admission, compared with healthy individuals, ICH patients had increased maximum clot firmness (EXTEM P <.0001; INTEM P <.0001; FIBTEM P <.0001), increased platelet maximum clot elasticity (P <.0001) in ROTEM, higher peak thrombin (P <.0001) and endogenous thrombin potential (P =.01) in thrombin generation, and elevated TAT complex levels. During 24 hours after significantly, while thrombin generation showed decreased peak thrombin (P <.0001) and endogenous thrombin potential (P <.0001). Coagulation test results did not differ between patients when stratified according to clinical outcome. Conclusions: ICH patients without anticoagulant or antiplatelet therapy demonstrated activated coagulation at admission and within 24 hours after symptom onset.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antithrombin III
KW - Biomarkers/blood
KW - Blood Coagulation
KW - Case-Control Studies
KW - Cerebral Hemorrhage/blood
KW - Denmark
KW - Disability Evaluation
KW - Female
KW - Hospitals, University
KW - Humans
KW - Male
KW - Middle Aged
KW - Patient Admission
KW - Peptide Hydrolases/blood
KW - Predictive Value of Tests
KW - Prospective Studies
KW - Thrombelastography
KW - Thrombin/metabolism
KW - Time Factors
U2 - 10.1016/j.jstrokecerebrovasdis.2018.06.022
DO - 10.1016/j.jstrokecerebrovasdis.2018.06.022
M3 - Journal article
C2 - 30072172
VL - 27
SP - 2951
EP - 2961
JO - Journal of Stroke & Cerebrovascular Diseases
JF - Journal of Stroke & Cerebrovascular Diseases
SN - 1052-3057
IS - 11
ER -