Signe Maria Nielsen

Molecular Organization of Small Plasmids Bearing blaTEM-1 and Conferring Resistance to beta-lactams in Haemophilus influenzae

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TEM-1 is the dominat β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids from 4,304 to 5,646 nt were characterized: pA1606, pA1209 and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 encodes a Tn3 resolvase gene and pA1606 and pA1209 encode an ORF similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Publication statusPublished - 2012

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