Sebastian Schlafer

Dr. , Associate Professor, Part-time Lecturer

Profile photoSebastian Schlafer
Associate professor
Department of Dentistry and Oral Health - Section for Operative Dentistry, Dental Pathology and Endodontics
Department of Bioscience - Microbiology

Postal address:
Vennelyst Boulevard 9
1610, 480
8000
Aarhus C
Denmark

Email: sebastians@dent.au.dk
Phone: +4587167451

Academic responsible for teaching in material science, restorative and aesthetic dentistry
Coordinator of Simulation Clinics.

Research focus: Study of the composition, architecture and metabolic activity of dental biofilms, with particular focus on the dental biofilm matrix. Development of non-bactericidal therapeutic approaches to biofilm control.

Research outputs

Fluorescence lectin binding analysis of carbohydrate components in dental biofilms grown in situ in the presence or absence of sucrose

Dige, I., Paque, P. N., Del Rey, Y. C., Lund, M. B., Schramm, A. & Schlafer, S., 29 Aug 2022, (E-pub ahead of print) In: Molecular Oral Microbiology. 10 p.

Prevention of Initial Bacterial Attachment by Osteopontin and Other Bioactive Milk Proteins

Kristensen, M. F., Sorensen, E. S., Del Rey, Y. C. & Schlafer, S., Aug 2022, In: Biomedicines. 10, 8, 8 p., 1922.

A simple method for semi-automated planimetric quantification of dental plaque using light-induced fluorescence

Schlafer, S., Rikvold, P., Kambourakis Johnsen, K. & Chokyu Del Rey, Y., Jul 2022.

A simple method for semi-automated planimetric quantification of dental plaque using light-induced fluorescence

Schlafer, S., Rikvold, P., Kambourakis Johnsen, K. & Chokyu Del Rey, Y., Jul 2022, In: Caries Research. 56

Quantification of undisclosed and disclosed dental plaque using light-induced fluorescence

Chokyu Del Rey, Y., Rikvold, P., Kambourakis Johnsen, K. & Schlafer, S., Jul 2022.

Quantification of undisclosed and disclosed dental plaque using light-induced fluorescence

Chokyu Del Rey, Y., Rikvold, P., Kambourakis Johnsen, K. & Schlafer, S., Jul 2022, In: Caries Research. 56

Open Wide: Didactic Rationales of a Dental Video Library

Pedersen, K., Kruse, C. & Schlafer, S., 2 Jun 2022.

A New Device for In Situ Dental Biofilm Collection Additively Manufactured by Direct Metal Laser Sintering and Vat Photopolymerization

Rikvold, P. T., Johnsen, K. K., Leonhardt, D., Mollebjerg, A., Nielsen, S. M., Hansen, L. B. S., Meyer, R. L. & Schlafer, S., 12 May 2022, (E-pub ahead of print) In: 3D Printing and Additive Manufacturing. 10 p.

A comparison of video-based and slide-based teaching before hands-on rubber dam application: A quantitative and qualitative study

Kruse, C., Schlafer, S. & Pedersen, K., Mar 2022, In: Journal of Dental Education. 86, 3, p. 334-342 9 p.

Reduction of dual-species biofilm after sonic- or ultrasonic-activated irrigation protocols: A laboratory study

Hoedke, D., Kaulika, N., Dommisch, H., Schlafer, S., Shemesh, H. & Bitter, K., Dec 2021, In: International Endodontic Journal. 54, 12, p. 2219-2228 10 p.

The impact of glass ionomer cement and composite resin on microscale pH in cariogenic biofilms and demineralization of dental tissues

Schlafer, S., Bornmann, T., Paris, S. & Göstemeyer, G., Oct 2021, In: Dental Materials. 37, 10, p. 1576-1583 8 p.

Lactobacillus reuteri and Streptococcus oligofermentans are efficient colonizers in a multi-species model of cariogenic biofilm

Rikvold, P., Grønkjær, L., Chen, Z., Göstemeyer, G., Schwendicke, F. & Schlafer, S., 8 Jul 2021.

Ratiometric analysis of local S. mutans biofilm pH on tooth and restoration surfaces

Schlafer, S., Bornmann, T., Paris, S. & Göstemeyer, G., 8 Jul 2021.

Ratiometric analysis of local S. mutans biofilm pH on tooth and restoration surfaces.

Schlafer, S., Bornmann, T., Paris, S. & Göstemeyer, G., Jul 2021.

Hands-on live demonstration vs. video-supported demonstration of an aesthetic composite restoration in undergraduate dental teaching

Schlafer, S., Pedersen, K., Jørgensen, J. N. & Kruse, C., Jun 2021, In: Journal of Dental Education. 85, 6, p. 802-811 10 p.

Root caries preventive effect of varnishes containing fluoride or fluoride + chlorhexidine/cetylpyridinium chloride in vitro

Göstemeyer, G., Woike, H., Paris, S., Schwendicke, F. & Schlafer, S., Apr 2021, In: Microorganisms. 9, 4, 13 p., 737.

The whitening effect of single brushing with blue-covarine containing toothpaste-A randomized controlled trial

Schlafer, S., Poulsen, P. N., Johansen, J., Trap, L. & Leite, F. R. M., Feb 2021, In: Journal of Dentistry. 105, 4 p., 103559.

Ratiometric imaging of extracellular pH in Streptococcus mutans biofilms exposed to different flow velocities and saliva film thicknesses

Kristensen, M. F., Frandsen Lau, E. & Schlafer, S., 2021, In: Journal of Oral Microbiology. 13, 1, 13 p., 1949427.

Probiotic Effects on Multispecies Biofilm Composition, Architecture, and Caries Activity In Vitro

Chen, Z., Schlafer, S., Göstemeyer, G. & Schwendicke, F., Sep 2020, In: Microorganisms. 8, 9, 13 p., 1272.

A 3D printed Microfluidic Flow-Cell for Microscopy Analysis of In Situ-Grown Biofilms

Kristensen, M. F., Leonhardt, D., Neland, M. L. B. & Schlafer, S., Jul 2020, In: Caries Research.

Design of a new intraoral splint with 3D-printed inserts for dental biofilm collection

Schlafer, S., Møllebjerg, A., Kambourakis Johnsen, K., Nielsen, S. M. & Meyer, R. L., Jul 2020, In: Caries Research.

A 3D printed microfluidic flow-cell for microscopy analysis of in situ-grown biofilms

Kristensen, M. F., Leonhardt, D., Neland, M. L. B. & Schlafer, S., Apr 2020, In: Journal of Microbiological Methods. 171, 6 p., 105876.

Bakterien im Mund - Freund oder Feind?

Schlafer, S., 2020, In: Oralprophylaxe & Kinderzahnheilkunde. 41, 4, p. 169-174 6 p.

Monitoring Extracellular pH in Cross-Kingdom Biofilms using Confocal Microscopy

Schlafer, S. & Frost Kristensen, M., 2020, In: Journal of visualized experiments : JoVE. 155

Caries-Preventive Effect of Fluoride and Fluoride+Chlorhexidine Varnishes in vitro

Göstemeyer, G., Woike, H., Schwendicke, F., Paris, S. & Schlafer, S., 2019, In: Journal of Dental Research. 97, B, p. 3 1 p., 0005.

Prevention Of Bacterial Adhesion By Bioactive Milk Proteins

Schlafer, S., Sørensen, E. S. & Kristensen, M. F., 2019, In: Journal of Dental Research. 98, A, Presentation ID: 2624.

Improved pH-ratiometry for the three-dimensional mapping of pH microenvironments in biofilms under flow conditions

Schlafer, S., Baelum, V. & Dige, I., Sep 2018, In: Journal of Microbiological Methods. 152, p. 194-200 7 p.

Removal of Artificial Biofilm Using Different Methods of Activation

Kaulika, N., Hoedke, D., Schlafer, S. & Bitter, K., 27 Jul 2018.

Ratiometric analysis of pH in different layers of 48-h and 120-h dental biofilms

Schlafer, S., Bælum, V. & Dige, I., 5 Jul 2018, In: Caries Research. 52, p. 485-485 1 p.

The use of pH ratiometry to measure extracellular pH in biofilms of Candida spp

Garcia, J., Kamp, A. & Schlafer, S., 5 Jul 2018, p. 485-485. 1 p.

Effect of photodynamic therapy in combination with various irrigation protocols on an endodontic multispecies biofilm ex vivo

Hoedke, D., Enseleit, C., Gruner, D., Dommisch, H., Schlafer, S., Dige, I. & Bitter, K., 15 Jan 2018, In: International Endodontic Journal. 51, S1, p. e23-e34 12 p.

A confocal microscopy based method to monitor extracellular pH in fungal biofilms

Schlafer, S., Kamp, A. & Garcia, J., 2018, In: FEMS Yeast Research. 18, 5, 8 p., 049.

Effect of DNase treatment on adhesion and early biofilm formation of Enterococcus faecalis

Schlafer, S., Garcia, J., Meyer, R. L., Vaeth, M. & Neuhaus, K. W., 2018, In: European Endodontic Journal. 3, 2, p. 82-86 5 p.

Osteopontin adsorption to Gram-positive cells reduces adhesion forces and attachment to surfaces under flow

Kristensen, M. F., Zeng, G., Neu, T. R., Meyer, R. L., Baelum, V. & Schlafer, S., 11 Oct 2017, In: Journal of Oral Microbiology. 9, 10 p., 1379826.

Confocal Microscopy Monitoring of pH Dynamics in a 5-Species Dental Biofilm Model Under Flow Conditions

Schlafer, S. & Dige, I., 1 Aug 2017, In: Caries Research. 51, p. 295 1 p.

Extracellular DNA Contributes to Dental Biofilm Stability

Schlafer, S., Meyer, R. L., Dige, I. & Regina, V. R., 1 Aug 2017, In: Caries Research. 51, p. 436-442 7 p.

Visualizing the dental biofilm matrix by means of fluorescence lectin-binding analysis

Tawakoli, P. N., Neu, T. R., Busck, M. M., Kuhlicke, U., Schramm, A., Attin, T., Wiedemeyer, D. B. & Schlafer, S., 9 Jul 2017, In: Journal of Oral Microbiology. 9, 1

Confocal microscopy imaging of the biofilm matrix

Schlafer, S. & Meyer, R. L., Jul 2017, In: Journal of Microbiological Methods. 138, p. 50-59 10 p.

Examination of the Dental Biofilm Matrix by Fluorescence Lectin-Binding Analysis

Tawakoli, P. N., Schlafer, S., Busck, M. M., Schramm, A., Attin, T., Wiedemeyer, D., Kuhlicke, U. & Neu, T., 24 Mar 2017.

Calcium-Phosphate-Osteopontin Particles Reduce Biofilm Formation and pH Drops in in situ-Grown Dental Biofilms

Schlafer, S., Ibsen, C. J. S., Birkedal, H. & Nyvad, B., 2017, In: Caries Research. 51, p. 26-33 8 p.

Osteopontin Reduces the Adhesion Force of Dental Bacteria Without Blocking Bacterial Cell Surface Glycoconjugates

Kristensen, M. F., Zeng, G., Neu, T. R., Meyer, R. L. & Schlafer, S., 2017, In: Caries Research. 51, p. 299-299 1 p., 19.

Wirksamkeit der adjuvanten photodynamischen Therapie auf einen Multispezies-Biofilmim Wurzelkanal ex vivo

Hoedke, D., Enseleit, C., Neumann, K., Schlafer, S., Dige, I., Dommisch, H. & Bitter, K., 8 Oct 2016.

Monitoring of extracellular pH in young dental biofilms grown in situ in the presence and absence of sucrose

Dige, I., Bælum, V., Nyvad, B. & Schlafer, S., 6 Jul 2016.

Bovine milk osteopontin - Targeting bacterial adhesion for biofilm control

Kristensen, M. F., Meyer, R. L. & Schlafer, S., 2016, In: Caries Research. 50, p. 185 1 p., 11.

Calcium-phosphate-osteopontin particles for caries control

Schlafer, S., Birkedal, H., Olsen, J., Skovgaard, J., Sutherland, D., Wejse, P. L., Nyvad, B. & Meyer, R. L., 2016, In: Biofouling. p. 349-357 9 p.

Extracellular DNA contributes to dental biofilm formation: An ex vivo study

Schlafer, S., Meyer, R. L., Dige, I. & Regina, V. R., 2016, In: Caries Research. 50, p. 182 1 p., 3.

Monitoring of extracellular pH in young dental biofilms grown in situ in the presence and absence of sucrose

Dige, I., Bælum, V., Nyvad, B. & Schlafer, S., 2016, In: Caries Research. p. 182-182 1 p.

Monitoring of extracellular pH in young dental biofilms grown in vivo in the presence and absence of sucrose

Dige, I., Baelum, V., Nyvad, B. & Schlafer, S., 2016, In: Journal of Oral Microbiology. 8, p. 30390 8 p.

Ratiometric Imaging of Extracellular pH in Dental Biofilms.

Schlafer, S. & Dige, I., 2016, In: Journal of Visualized Experiments. p. e53622

Comparison of Riboflavin and Toluidine Blue O as Photosensitizers for Photoactivated Disinfection on Endodontic and Periodontal Pathogens In Vitro

Nielsen, H. K., Garcia, J., Væth, M. & Schlafer, S., 15 Oct 2015, In: P L o S One. 11 p., 10.1371/journal.pone.0140720.

Carieskontrol I tandlægepraksis

Nyvad, B., Dige, I., Richards, A. & Schlafer, S., 6 Oct 2015, In: Tandlaegebladet. 119, 10, p. 836-847 12 p.

Microscopic monitoring of extracellular pH in dental biofilms

Schlafer, S., Garcia, J., Greve, M., Raarup, M. K., Nyvad, B. & Dige, I., Jun 2015.

Ratiometric Imaging of Extracellular pH in Dental Biofilms Using C-SNARF-4

Dige, I., Nyvad, B., Bælum, V. & Schlafer, S., 14 Mar 2015.

Ratiometric imaging of extracellular pH in bacterial biofilms with C-SNARF-4

Schlafer, S., Garcia, J., Rasmussen, M. G., Raarup, M. K., Nyvad, B. & Dige, I., 2015, In: Applied and Environmental Microbiology. 81, 4, p. 1267-1273 7 p.

Calcium-phosphate-osteopontin particles for caries control

Schlafer, S., May 2014.

Calcium-Phosphate-Osteopontin Particles: A New Approach to Caries Control

Schlafer, S., Olsen, J., Skovgaard, J., Birkedal, H., Nyvad, B., Sutherland, D. S., Wejse, P. & Meyer, R. L., 10 Sep 2013.

Effect of Osteopontin on the Initial Adhesion of Dental Bacteria

Schlafer, S., Sep 2013.

Infiltration of natural caries lesions in relation to their activity status and acid pretreatment in vitro

Neuhaus, K. W., Schlafer, S., Lussi, A. & Nyvad, B., 2013, In: Caries Research. 47, 3, p. 203-210 8 p.

Osteopontin Reduces Biofilm Formation in a Multi-Species Model of Dental Biofilm

Schlafer, S., Raarup, M. K., Wejse, P. L., Nyvad, B., Stadler, B. M., Sutherland, D. S., Birkedal, H. & Meyer, R. L., 7 Aug 2012, In: P L o S One. 7, 8, p. e41534

Difference in initial dental biofilm accumulation between night and day

Dige, I., Schlafer, S. & Nyvad, B., 2012, In: Acta Odontologica Scandinavica. 70, 6, p. 441-447

Effect of Osteopontin on the Initial Adhesion of Dental Bacteria

Schlafer, S., Meyer, R. L., Sutherland, D. S. & Stadler, B. M., 2012, In: Journal of Natural Products. 75, 12, p. 2108-2012 5 p.

pH Landscapes in a Novel Five-Species Model of Early Dental Biofilm

Schlafer, S., Raarup, M. K., Meyer, R. L., Sutherland, D. S., Dige, I., Nyengaard, J. R. & Nyvad, B., 2011, In: P L o S One. 6, 9, p. e25299

Endodontic photoactivated disinfection using a conventional light source: an in vitro and ex vivo study

Schlafer, S., Vaeth, M., Hørsted-Bindslev, P. & Frandsen, E. V. G., 2010, In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 109, 4, p. 634-41 8 p.