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Seandean Lykke Harwood

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  1. 2023
  2. Published
    Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1. / Rasmussen, Casper Bøjer; Scavenius, Carsten; Thøgersen, Ida B et al.
    In: Frontiers in Microbiology, Vol. 14, 1121857, 2023.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  3. 2022
  4. Published
    Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity. / Hangiu, Oana; Compte, Marta; Dinesen, Anders et al.
    In: iScience, Vol. 25, No. 9, 104958, 16.09.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  5. Published
    Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein. / Harwood, Seandean Lykke; Andersen, Gregers Rom; Enghild, Jan J.
    In: Proceedings of the National Academy of Sciences, Vol. 119, No. 37, e2210218119, 09.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review

  6. Published
    The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel. / Harwood, Seandean Lykke; Diep, Khang; Nielsen, Nadia Sukusu et al.
    In: Journal of Biological Chemistry, Vol. 298, No. 8, 102230, 08.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  7. Published
    Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. / Nielsen, Nadia Sukusu; Zarantonello, Alessandra; Harwood, Seandean Lykke et al.
    In: Nature Communications, Vol. 13, No. 1, 3033, 05.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  8. Published
    Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers. / Blanco, Belén; Ramírez-Fernández, Ángel; Bueno, Clara et al.
    In: Cancer Immunology Research, Vol. 10, No. 4, 04.2022, p. 498-511.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  9. Published
    Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. / Tapia-Galisteo, Antonio; Sánchez Rodríguez, Íñigo; Aguilar-Sopeña, Oscar et al.
    In: OncoImmunology, Vol. 11, No. 1, 2034355, 2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  10. 2021
  11. Published
    Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin. / Harwood, Seandean Lykke; Nielsen, Nadia Sukusu; Diep, Khang et al.
    In: The Journal of Biological Chemistry, Vol. 297, No. 1, 100879, 07.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  12. Published
    Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy. / Nielsen, Nadia Sukusu; Gadeberg, Trine A F; Poulsen, Ebbe Toftgaard et al.
    In: The Journal of Biological Chemistry, Vol. 297, No. 1, 100858, 07.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  13. Published
    An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad antitumor activity in humanized murine cancer models without toxicity. / Compte, Marta; Harwood, Seandean L.; Erce-Llamazares, Ainhoa et al.
    In: Clinical Cancer Research, Vol. 27, No. 11, 06.2021, p. 3167-3177.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  14. Published
    Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism. / Harwood, Seandean Lykke; Lyngsø, Jeppe; Zarantonello, Alessandra et al.
    In: Molecular and Cellular Proteomics, Vol. 20, 100090, 05.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  15. Published
    α2-macroglobulin: Investigation of its native conformation, bait region, and thiol ester using mass spectrometry and mutant characterization. / Harwood, Seandean Lykke.
    Aarhus: Aarhus Universitet, Institut for Molekylærbiologi og genetik, 2021. 195 p.

    Research output: Book/anthology/dissertation/report › Ph.D. thesis

  16. Published
    Correction: α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester (The Journal of biological chemistry (2020) 295 49 (16732-16742) PII: S0021-9258(20)00204-5). / Harwood, Seandean Lykke; Nielsen, Nadia Sukusu; Jensen, Kathrine Tejlgård et al.
    In: The Journal of Biological Chemistry, Vol. 296, 01.01.2021, p. 100208.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

  17. Published
    Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR. / Compte, Marta; Harwood, Seandean L.; Martínez-Torrecuadrada, Jorge et al.
    In: Frontiers in Immunology, Vol. 11, 614363, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  18. Published
    α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester. / Harwood, Seandean Lykke; Nielsen, Nadia Sukusu; Jensen, Kathrine Tejlgård et al.
    In: Journal of Biological Chemistry, Vol. 296, 2021, p. 16732-16742.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  19. 2020
  20. Published
    α2-macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester. / Harwood, Seandean Lykke; Nielsen, Nadia Sukusu; Jensen, Kathrine Tejlgård et al.
    In: Journal of Biological Chemistry, Vol. 295, No. 49, 04.12.2020, p. 16732-16742.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  21. Published
    Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes. / Harwood, Seandean Lykke; Nielsen, Nadia Sukusu; Pedersen, Henrik et al.
    In: Biochemistry, Vol. 59, No. 51, 12.2020, p. 4799–4809.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  22. 2019
  23. Published
    Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies. / Mikkelsen, Kasper; Lykke Harwood, Seandean; Compte, Marta et al.
    In: Frontiers in Immunology, Vol. 10, 1791, 07.2019, p. 1791.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  24. 2018
  25. Published
    A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. / Compte, Marta; Harwood, Seandean Lykke; Muñoz, Ines G. et al.
    In: Nature Communications, Vol. 9, 4809 , 15.11.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  26. Published
    Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies. / Jensen, Kasper; Harwood, Seandean Lykke; Compte, Marta et al.
    In: Cancer Immunology, Immunotherapy, Vol. 67, No. 8, 08.2018, p. 1251-1260.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  27. Published
    ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy. / Harwood, Seandean Lykke; Alvarez-Cienfuegos, Ana; Alanes, Natalia Nuñez del Prado et al.
    In: OncoImmunology, Vol. 7, No. 1, e1377874, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  28. 2017
  29. Published
    Balanced secretion of anti-CEA x anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity. / Mølgaard , Kasper; Compte, Marta; Alanes, Natalia Nuñez del Prado et al.
    In: Gene Therapy, Vol. 24, No. 4, 2017, p. 208-214.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  30. 2016
  31. Published
    Efficacy and toxicity management of CAR-T cell immunotherapy: a matter of responsiveness control or tumor-specificity? / Alonso-Camino, Vanesa; Harwood, Seandean Lykke; Alvarez-Méndez, Ana M et al.
    In: Biochemical Society. Transactions, Vol. 44, No. 2, 2016, p. 406-411.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  32. Published
    Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains. / Álvarez-Cienfuegos, Ana; Alanes, Natalia Nuñez del Prado; Compte, Marta et al.
    In: Scientific Reports, Vol. 6, 28643, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review