Rune Thomsen

Cluster manager, Molecular Biologist

Profile photoRune Thomsen
Clustermanager, MSc, PhD
Department of Biomedicine
Wilhelm Meyers Allé 3, 1230, 325
8000, Aarhus C
Denmark
E-mail: rt@biomed.au.dk
Phone: +45 28 49 80 14

Academic degrees

2011PhD, Dept. of Biomedicine, Human Genetics, Aarhus University
2008MSc, Dept. of Molecular Biology, Aarhus University
2006BA, Biology, Aarhus University

Other degrees

2003Technician, Business Academy Aarhus

Employments

2016-2019 Molekylærbiolog, Pathology, AUH
2016Molecular biologist, Pathology, Vejle Sygehus
2013-2015Postdoc, Dept. of Molecularbiology and Genetics, Christian K Damgaard Lab
2012-2013Postdoc, Dept. of Clinical Medicine, Molekylær Medicinsk Afdeling (MoMA), AUH, Prof. Claus L. Andersen's group
2011-2012Scientific Assistant, Dept. of Biomedicine, Human Genetics, AU, Prof. Anders Lade Nielsen's group
2008-2011PhD fellow, Dept. of Human Genetics, AU, Prof. Anders Lade Nielsen's group
2003-2005Technician, Dept. of Molecular Biology, AU, Prof. Torben Heick Jensen's group
2002-2003Technician trainee, Dept. of Molecular Biology, AU, Prof. Torben Heick Jensen's group

Training

2009Visiting PhD student, 6 months at Dr. Robert H. Singer's research lab, Albert Einstein College of Medicine, New York.

Fellowships

2013-2015Post Doc fellowship, 2 years, Lundbeck Foundation
2011-2012Research fellowship, 4 months, Aarhus University Research Foundation
2008-2011PhD fellowship, 3 years, Faculty of Health Sciences, Aarhus University

Scholarships

2007-2008Lundbeck Foundation (100.000 DKK)
2006-2007Danish Cancer Society (120.000 DKK)

Grants

2008Lundbeck Foundation 1.259.000 DKK covering 3 year technician salary and running cost for PhD project , co-applied with Prof. Anders Lade Nielsen
2008Grosserer A.V. Lykfeldt og Hustrus legat (5000 DKK)
2007Kong Christian Den Tiendes Fond (15.000 DKK)

Publications

Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges

Hollensen, A. K., Thomsen, R., Bak, R. O., Petersen, C. C., Ermegaard, E. R., Aagaard, L., Damgaard, C. K. & Mikkelsen, J. G., Aug 2017, In : RNA. 23, 8, p. 1247-1258 12 p.

Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery

Reinert, T., Schøler, L. V., Thomsen, R., Tobiasen, H., Vang, S., Nordentoft, I. K., Lamy, P., Kannerup, A-S., Mortensen, F. V., Stribolt, K., Hamilton-Dutoit, S. J., Laurberg, S., Pallisgaard, N., Pedersen, J. S., Ørntoft, T. F. & Andersen, C. L., 2016, In : Gut. 65, 4, 10 p.

Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells

Vad-Nielsen, J., Jakobsen, K. R., Daugaard, T. F., Thomsen, R., Brügmann, A., Sørensen, B. S. & Nielsen, A. L., 2016, In : B M C Cancer. 16, 1, p. 32

DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1

Pettersson, O. J., Aagaard, L., Andrejeva, D., Thomsen, R., Jensen, T. G. & Damgaard, C. K., 3 May 2014, In : Nucleic Acids Research. 42, 11, p. 7186-7200 15 p.

Genome wide assessment of mRNA in astrocyte protrusions by direct RNA sequencing reveals mRNA localization for the intermediate filament protein nestin

Thomsen, R., Pallesen, J., Daugaard, T. F., Børglum, A. D. & Nielsen, A. L., 5 Sep 2013, In : Glia.

Direct RNA sequencing mediated identification of mRNA localized in protrusions of human MDA-MB-231 metastatic breast cancer cells

Jakobsen, K. R., Sørensen, E., Brøndum, K. K., Daugaard, T. F., Thomsen, R. & Nielsen, A. L., 1 Sep 2013, In : Journal of Molecular Signaling. 8, 9, p. 1-14 15 p.

Alternative mRNA Splicing from the Glial Fibrillary Acidic Protein (GFAP) Gene Generates Isoforms with Distinct Subcellular mRNA Localization Patterns in Astrocytes

Thomsen, R., Daugaard, T. F., Holm, I. E. & Nielsen, A. L., Aug 2013, In : PLOS ONE. 8, 8, p. 1-12 12 p., e72110.

RNA Localization in Astrocytes

Thomsen, R., 1 Jan 2012

Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules

Larsen, J., Pettersson, O. J., Jakobsen, M., Thomsen, R., Pedersen, C. B., Hertz, J. M., Gregersen, N., Corydon, T. J. & Jensen, T. G., 11 Nov 2011, In : BMC Research Notes. 4, p. 490

Analysis of HP1α regulation in human breast cancer cells

Thomsen, R., Christensen, D. B., Rosborg, S., Linnet, T. E., Blechingberg, J. & Nielsen, A. L., 1 Aug 2011, In : Molecular Carcinogenesis. 50, 8, p. 601-613

A Boyden chamber-based method for characterization of astrocyte protrusion localized RNA and protein

Thomsen, R. & Nielsen, A. L., 2011, In : Glia. 59, 11, p. 1782-92 11 p.

Analysis of qPCR data by converting exponentially related Ct values into linearly related X0 values

Thomsen, R., Sølvsten, C. A. E., Linnet, T. E., Blechingberg, J., Nielsen, A. L. & Nielsen, A. L., 1 Oct 2010, In : Journal of Bioinformatics and Computational Biology. 8, 5, p. 885-900

The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells

Zhou, Z., Thomsen, R., Kahns, S., Nielsen, A. L. & Nielsen, A. L., 30 Jul 2010, In : Biochemical and Biophysical Research Communications. 398, 3, p. 565-570

General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants

Thomsen, R., Saguez, C., Nasser, T. & Jensen, T. H., 14 Apr 2008, In : RNA. 4, p. 706-716 11 p.

Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.

Rougemaille, M., Gudipati, R. K., Olesen, J. R., Thomsen, R., Seraphin, B., Libri, D. & Jensen, T. H., 5 Apr 2007, In : E M B O Journal. 26, p. 2317-2326 10 p.

Dramatically improved RNA in situ hybridization signals using LNA-modified probes.

Thomsen, R., Nielsen, P. S. & Jensen, T. H., 21 Sep 2005, In : RNA. 11, p. 1745-1748 4 p.

Localization of nuclear retained mRNAs in Saccharomyces cerevisiae

Thomsen, R., Libri, D., Boulay, J., Rosbash, M. & Jensen, T. H., 1 Sep 2003, In : RNA. 9, p. 1049-1057 9 p.

Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation.

Libri, D., Dower, K., Boulay, J., Thomsen, R., Rosbash, M. & Jensen, T. H., 1 Dec 2002, In : Molecular and Cellular Biology. 22, 23, p. 8254-8266 13 p.