Projects per year
Personal profile
Research
I study how early life adversity shapes neurodevelopment and increases risk for psychiatric disorders, particularly substance use disorders. Using human cohorts, rodent models, and in vitro systems, I investigate molecular mechanisms involving stress, epigenetics, extracellular vesicles, and neuroimaging. I maintain a strong international network, especially with Brazil and the United States.
Commissioned
I provide consultancy in neuroscience, developmental neurobiology, and molecular and biological psychiatry. I advise on study design, neuroimaging, omics approaches, and nanotools in translational research. I serve as an ad hoc reviewer, participate in evaluation boards, and collaborate with industry partners.
Cooperation and dissemination
I collaborate through major consortia such as HappyMums (Horizon Europe, 17+ partners), the ENIGMA Addiction Working Group, the MIND Consortium (Neuroimaging and Epigenetics), the Brazilian Children High-Risk Cohort , and a GWAS/EWAS cohort focused on cocaine dependence. My network spans Europe, North and South America, fostering active partnerships with universities and research institutes and supporting continuous exchange of students, postdoctoral fellows, and faculty members.
Teaching
I teach at undergraduate and graduate levels in neuroscience, psychiatry, and molecular biology. I have supervised over 120 students across all levels. My teaching focuses on neurodevelopment, early adversity, stress biology, addiction neuroscience, neuroimaging, and epigenetic regulation, with active participation in international exchange programs.
Education/Academic qualification
Psychiatry, Medical Residency, Universidade Federal de Ciencias da Saúde de Porto Alegre
1 Jan 2002 → 31 Dec 2003
Award Date: 31 Dec 2003
Medicine, M.D., Universidade Federal de Ciencias da Saúde de Porto Alegre
1 Mar 1996 → 15 Dec 2001
Award Date: 15 Dec 2001
External positions
Full Professor, Pontifical Catholic University of Rio Grande do Sul School of Medicine, Porto Alegre, Brazil.
1 Aug 2022 → …
Associate Professor, Pontifical Catholic University of Rio Grande do Sul (PUCRS)
5 Aug 2008 → 31 Jul 2022
Keywords
- Biological stressors
- Endocrine disruptors
- Psychophysiology (hormones, immune system etc)
- Risk and health
- Molecular medicine
- Genetics
- Immunology
- Biological treatment
Areas of expertise
- Developmental Neuroscience
- Early Life Stress
- Substance Use Disorders
- Extracellular Vesicles
- Epigenetics
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Brain-Derived Extracellular Vesicles in Dual Diagnosis: Liquid Biopsy as a Promising Framework for Advancing Research and Treatment in Psychiatry
Grassi-Oliveira, R. (PI), Walss-Bass, C. (PI), Okeoma, C. (PI) & Wendt Viola, T. (PI)
01/02/2024 → 31/08/2027
Project: Research
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CannaBabies: Neuroepigenomics of THC and CBD Exposure during Pregnancy in the Developing Brain
Grassi-Oliveira, R. (PI), Sia, E. (Participant), Gobira Nunes, P. H. (Collaborator), Joca, S. (Collaborator) & Cruceanu, C. (Collaborator)
15/11/2023 → 14/11/2027
Project: Research
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An educational exhibit on female biology and women’s health at Science Museerne
Davis, F. M. (PI), Rågård, N. (CoPI), Vogel, I. (CoPI), Parsons, C. (CoPI), Smidt, K. (CoPI), Kirk, U. B. (CoPI), Chalmers, S. B. (CoPI), Paldam, E. (CoPI), McKerracher, L. J. (Participant), Joca, S. (Participant), Grassi-Oliveira, R. (Participant), Romero-Ramos, M. (Participant), Kalucka, J. M. (Participant), Bomholt Larsen, A. S. (Project manager), Skydsgaard, M. A. (Other), Kirkfeldt, S. S. (Other) & Lauridsen, K. (Other)
01/03/2023 → 29/02/2028
Project: Other
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Brain Aging Mechanisms Related To Stimulant Use Disorders
Grassi-Oliveira, R. (PI) & Wegener, G. (CoPI)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
01/02/2023 → 31/01/2027
Project: Research
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HappyMums: Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes
Grassi-Oliveira, R. (PI)
05/11/2022 → 04/11/2026
Project: Research
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Exploring the potential link between ΔFosB and N-acetylcysteine in craving/relapse dynamics: can N-acetylcysteine stand out as a possible treatment candidate?
Arjmand, S., Ilaghi, M., Shafie’ei, M., Gobira, P., Grassi-Oliveira, R. & Wegener, G., 17 Oct 2025, In: Acta Neuropsychiatrica. 37, p. 1-14 14 p., e31.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study
Ota, V. K., Oliveira, A. M., Bugiga, A. V. G., Conceição, H. B., Galante, P. A. F., Asprino, P. F., Schäfer, J. L., Hoffmann, M. S., Bressan, R., Brietzke, E., Manfro, G. G., Grassi-Oliveira, R., Gadelha, A., Rohde, L. A., Miguel, E. C., Pan, P. M., Santoro, M. L., Salum, G. A., Carvalho, C. M. & Belangero, S. I., 2025, In: Frontiers in Psychiatry. 16, 1505421.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
Sex-Specific Effects of Early-Life Stress Exposure on Memory Performance and the Medial Prefrontal Cortex Transcriptomic Pattern in Adolescent Mice
Orso, R., Viola, T. W., Heberle, B. A., Creutzberg, K. C., Lumertz, F. S. & Grassi-Oliveira, R., 2025, (E-pub / Early view) In: Molecular Neurobiology. 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study
HappyMums Consortium, Mar 2025, In: Brain, Behavior, and Immunity - Health. 44, 100961.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
A single dose of cocaine raises SV2A density in hippocampus of adolescent rats
Rossi, R., Bærentzen, S. L., Thomsen, M., Real, C. C., Wegener, G., Grassi-Oliveira, R., Gjedde, A. & Landau, A., Apr 2024, In: Acta Neuropsychiatrica. 36, 2, p. 109-117 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)8 Downloads (Pure)
Activities
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Thiago Wendt Viola
Grassi-Oliveira, R. (Host)
1 May 2023 → 1 Aug 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Pontifical Catholic University of Rio Grande do Sul (PUCRS)
Grassi-Oliveira, R. (Visiting researcher)
1 Aug 2022 → …Activity: Visiting an external institution types › Visiting an external academic institution
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Cocaine addiction and Early Life Stress
Grassi-Oliveira, R. (Lecturer)
15 Jul 2021Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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Pontifical Catholic University of Rio Grande do Sul School of Medicine, Porto Alegre, Brazil.
Grassi-Oliveira, R. (Visiting researcher)
2021 → …Activity: Visiting an external institution types › Visiting an external academic institution