Rikke Holm

  1. 2019
  2. Published

    Functional consequences of the CAPOS mutation E818K of Na+,K+-ATPase. / Roenn, Christian P; Li, Melody; Schack, Vivien R; Forster, Ian C; Holm, Rikke; Toustrup-Jensen, Mads S; Andersen, Jens P; Petrou, Steven; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 294, No. 1, 04.01.2019, p. 269-280.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    Distinct effects of Q925 mutation on intracellular and extracellular Na+ and K+ binding to the Na+, K+-ATPase. / Nielsen, Hang N; Spontarelli, Kerri; Holm, Rikke; Andersen, Jens Peter; Einholm, Anja P.; Artigas, Pablo; Vilsen, Bente.

    In: Scientific Reports, Vol. 9, No. 1, 13344, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. 2018
  5. Published

    Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability. / Schlingmann, Karl P; Bandulik, S; Mammen, C; Tarailo-Graovac, M; Jensen, Rikke Holm; Baumann, M; König, J; Lee, JJY; Drögemøller, B; Imminger, K; Beck, BB; Altmüller, J; Thiele, H; Waldegger, S; Van't Hoff, W; Kleta, R; Warth, R; van Karnebeek, CDM; Vilsen, Bente; Bockenhauer, Detlef; Konrad, M.

    In: American Journal of Human Genetics, Vol. 103, No. 5, 01.11.2018, p. 808-816.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2017
  7. Published

    Arginine replacement of Cys932 converts Na,K-ATPase to an electroneutral pump. Poster presented by Rikke Holm at the 15th International Conference on Na,K-ATPase and related Transport ATPases, Otsu, Japan, 2017. / Jensen, Rikke Holm; Khandelwal, Jaanki; Einholm, Anja P.; Andersen, Jens Peter; Artigas, Pablo; Vilsen, Bente.

    2017. Poster session presented at The 15th International Conference on Na,K-ATPase and related transport ATPases, Japan.

    Research output: Contribution to conferencePosterResearch

  8. Published

    Astrocytic Na,K-ATPase a2b1 and a2b2 manages [K+]o differently during synaptic activity. Poster at the 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan, 2017. / Larsen, Brian Roland; Stoica, Anca; Assentoft, Mette; Jensen, Rikke Holm; Holt, Leanne M.; Lykke-Hartmann, Karin; Olsen, Michelle L.; Vilsen, Bente; MacAulay, Nanna.

    2017.

    Research output: Contribution to conferencePosterResearch

  9. Published
  10. Published

    Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase. / Holm, Rikke ; Khandelwal, J; Einholm, Anja P.; Andersen, Jens Peter; Artigas, Pablo; Vilsen, Bente.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 2, 10.01.2017, p. 316-321.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. / Stoica, Anca; Larsen, Brian; Assentoft, Mette; Jensen, Rikke Holm; Holt, Leanne; Vilhardt, Frederik; Vilsen, Bente; Lykke-Hartmann, Karin; MacAulay, Nanna.

    In: Glia, Vol. 65, No. 11, 2017, p. 1777-1793.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. 2016
  13. Published

    Glutamate transporter activity promotes enhanced Na+/K+-ATPase -mediated extracellular K+ management during neuronal activity. / Larsen, Brian R; Holm, Rikke; Vilsen, Bente; Macaulay, Nanna.

    In: The Journal of Physiology, Vol. 594, No. 22, 15.11.2016, p. 6627-6641.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function. / Holm, Rikke ; Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Andersen, Jens Peter; Vilsen, Bente.

    In: B B A - Bioenergetics, Vol. 1857, No. 11, 11.2016, p. 1807–1828.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  15. Published

    Importance of a potential protein kinase A phosphorylation site of Na+,K+-ATPase and its interaction network for Na+ binding. / Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 291, No. 20, 13.05.2016, p. 10934-47.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published
  17. 2015
  18. Published

    Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314. / Holm, Rikke; Einholm, Anja P; Andersen, Jens P; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 290, No. 15, 10.04.2015, p. 9801-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. 2014
  20. Published

    Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Nielsen, Hang Nguyen; Holm, Rikke; Sobrido, Maria-Jesus; Andersen, Jens Peter; Clausen, Torben; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  21. Published

    Rescue of Na+ and H+ binding in Na+,K+-ATPase M8 aspartate mutants by secondary mutation. / Holm, Rikke; Einholm, Anja P.; Andersen, Jens Peter; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  22. Published

    GIutamate-induced astrocytic [Na+]i elevation – a mechanism to increase K+ clearance via the Na+/K+-ATPase? / Larsen, Brian R; Holm, Rikke; Vilsen, Bente; Macaulay, Nanna.

    2014. Poster session presented at 46th Sandbjerg Meeting on Membrane Transport, Denmark.

    Research output: Contribution to conferencePosterResearch

  23. Published

    Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Nielsen, Hang Nguyen; Holm, Rikke; Sobrido, María-Jesús; Andersen, Jens Peter; Clausen, Torben; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 289(6), 07.02.2014, p. 3186-3197.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Elucidation of the functional role of a potential PKA site in Na+,K+-ATPase: Importance of Ser938 in binding of intracellular Na+. / Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    2014. Poster session presented at 14th International Conference Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  25. 2012
  26. Published

    Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion. / Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2012. Poster session presented at 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  27. Published

    Inhibition of Phosphorylation of Na+,K+-ATPase by Mutations Causing Familial Hemiplegic Migraine. / Schack, Vivien Rodacker; Holm, Rikke; Rønn, Christian Philip; Vilsen, Bente.

    2012. Poster session presented at 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  28. Published

    Inhibition of phosphorylation of Na+,K+-ATPase by mutations causing familial hemiplegic migraine. / Schack, Vivien Rodacker; Holm, Rikke; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 287, No. 3, 2012, p. 2191-202.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published
  30. Published
  31. 2011
  32. Published

    Destabilization of the Rossmann fold of Na+,K+-ATPase by mutations causing Familial Hemiplegic Migraine. / Schack, Vivien Rodacker; Holm, Rikke; Vilsen, Bente.

    2011. Poster session presented at 13th International P-type ATPase meeting, Pacific Grove, United States.

    Research output: Contribution to conferencePosterResearch

  33. Published

    Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion. / Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  34. Published

    The rapid-onset dystonia parkinsonism mutation D923N of the Na+,K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site and leads to a rise in intracellular Na+ in cell cultur. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  35. Published

    Two neurological disease mutations in the C-terminus of the Na+,K+-ATPase change the intracellular Na+ and K+ content in transfected mammalian COS-1 cell lines. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Clausen, Torben; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  36. 2010
  37. Published

    The rapid-onset dystonia Parkinsonism mutation D923N of the Na+,K+-ATPase alpha-3 isoform disrupts Na+interaction at the third Na+ site. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 285, No. 34, 20.08.2010, p. 26245-26254.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions. / Gredilla, Ricardo; Garm, Christian; Holm, Rikke; Bohr, Vilhelm A; Stevnsner, Tinna.

    In: Neurobiology of Aging, Vol. 31, No. 6, 2010, p. 993-1002.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. 2009
  40. Published

    A new RDP mutation of ATP1A3 with an in-frame insertion of a tyrosine at the very C-terminus of the protein provides further evidence for a key regulatory role of the C-terminal tail of Na+,K+-ATPase. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Blanco-Arias, Patricia; Mamsa, Hafsa; Concheiro, Carla; Gutiérrez-Terán, Hugo; Romero, Jesús; Carracedo, Ángel; Jen, Joanna; Sorbrido, María-Jesús; Vilsen, Bente.

    2009. Poster session presented at 2nd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  41. Published

    Functional analysis of Na+,K+-ATPase mutations associated with two neurological disorders. / Schack, Vivien Rodacker; Holm, Rikke; Vilsen, Bente.

    2009. Poster session presented at 2nd International Workshop on Expression, Structure and Function of Membrane Proteins, Firenze, Italy.

    Research output: Contribution to conferencePosterResearch

  42. Published

    The C Terminus of Na+,K+-ATPase Controls Na+ Affinity on Both Sides of the Membrane through Arg935. / Toustrup-Jensen, Mads Schak; Holm, Rikke; Einholm, Anja P.; Schack, Vivien Rodacker; Morth, Jens Preben; Nissen, Poul; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 284, No. 28, 2009, p. 18715-18725.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. 2008
  44. Published

    Importance of Ser938 for Na+ binding to Na+,K+-ATPase. / Einholm, Anja P.; Jensen, Rikke Holm; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2008. Poster session presented at 12th International ATPase Conference: Na,K-ATPase and Related Transport ATPases of P-type: Structures, Mechanisms, and Roles in Health and Disease., Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch