Poul Henning Jensen

Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. / Hsiao, Jen Hsiang T.; Purushothuman, Sivaraman; Jensen, Poul H. et al.

In: Frontiers in Neuroscience, Vol. 13, 1187, 01.11.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hsiao, JHT, Purushothuman, S, Jensen, PH, Halliday, GM & Kim, WS 2019, 'Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain', Frontiers in Neuroscience, vol. 13, 1187. https://doi.org/10.3389/fnins.2019.01187

APA

Hsiao, J. H. T., Purushothuman, S., Jensen, P. H., Halliday, G. M., & Kim, W. S. (2019). Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. Frontiers in Neuroscience, 13, [1187]. https://doi.org/10.3389/fnins.2019.01187

CBE

Hsiao JHT, Purushothuman S, Jensen PH, Halliday GM, Kim WS. 2019. Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. Frontiers in Neuroscience. 13:Article 1187. https://doi.org/10.3389/fnins.2019.01187

MLA

Vancouver

Hsiao JHT, Purushothuman S, Jensen PH, Halliday GM, Kim WS. Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. Frontiers in Neuroscience. 2019 Nov 1;13. 1187. https://doi.org/10.3389/fnins.2019.01187

Author

Hsiao, Jen Hsiang T. ; Purushothuman, Sivaraman ; Jensen, Poul H. et al. / Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. In: Frontiers in Neuroscience. 2019 ; Vol. 13.

Bibtex

@article{94bc60d4bdd04e649f05b5dcc77e20cb,
title = "Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain",
abstract = "Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain populations. Also, deficits in the level of coenzyme Q10 and its biosynthetic enzymes are associated with MSA. Here, we measured ATP levels and expression of biosynthetic enzymes for coenzyme Q10, including COQ2, in multiple regions of MSA and control brains. We found a reduction in ATP levels in disease-affected regions of MSA brain that associated with reduced expression of COQ2 and COQ7, supporting the concept that abnormalities in the biosynthesis of coenzyme Q10 play an important role in the pathogenesis of MSA.",
keywords = "ATP, cerebellum, coenzyme Q, COQ2, COQ7, multiple system atrophy, parkinsonian disorders",
author = "Hsiao, {Jen Hsiang T.} and Sivaraman Purushothuman and Jensen, {Poul H.} and Halliday, {Glenda M.} and Kim, {Woojin Scott}",
year = "2019",
month = nov,
day = "1",
doi = "10.3389/fnins.2019.01187",
language = "English",
volume = "13",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

AU - Hsiao, Jen Hsiang T.

AU - Purushothuman, Sivaraman

AU - Jensen, Poul H.

AU - Halliday, Glenda M.

AU - Kim, Woojin Scott

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain populations. Also, deficits in the level of coenzyme Q10 and its biosynthetic enzymes are associated with MSA. Here, we measured ATP levels and expression of biosynthetic enzymes for coenzyme Q10, including COQ2, in multiple regions of MSA and control brains. We found a reduction in ATP levels in disease-affected regions of MSA brain that associated with reduced expression of COQ2 and COQ7, supporting the concept that abnormalities in the biosynthesis of coenzyme Q10 play an important role in the pathogenesis of MSA.

AB - Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain populations. Also, deficits in the level of coenzyme Q10 and its biosynthetic enzymes are associated with MSA. Here, we measured ATP levels and expression of biosynthetic enzymes for coenzyme Q10, including COQ2, in multiple regions of MSA and control brains. We found a reduction in ATP levels in disease-affected regions of MSA brain that associated with reduced expression of COQ2 and COQ7, supporting the concept that abnormalities in the biosynthesis of coenzyme Q10 play an important role in the pathogenesis of MSA.

KW - ATP

KW - cerebellum

KW - coenzyme Q

KW - COQ2

KW - COQ7

KW - multiple system atrophy

KW - parkinsonian disorders

UR - http://www.scopus.com/inward/record.url?scp=85075339409&partnerID=8YFLogxK

U2 - 10.3389/fnins.2019.01187

DO - 10.3389/fnins.2019.01187

M3 - Journal article

C2 - 31736705

AN - SCOPUS:85075339409

VL - 13

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

M1 - 1187

ER -