Poul Henning Jensen

Phosphorylated α-synuclein in Parkinson's disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Phosphorylated α-synuclein in Parkinson's disease. / Wang, Yu; Shi, Min; Chung, Kathryn A; Zabetian, Cyrus P; Leverenz, James B; Berg, Daniela; Srulijes, Karin; Trojanowski, John Q; Lee, Virginia M-Y; Siderowf, Andrew D; Hurtig, Howard; Litvan, Irene; Schiess, Mya C; Peskind, Elaine R; Masuda, Masami; Hasegawa, Masato; Lin, Xiangmin; Pan, Catherine; Galasko, Douglas; Goldstein, David S; Jensen, Poul Henning; Yang, Hui; Cain, Kevin C; Zhang, Wen Jing.

In: Science Translational Medicine, Vol. 4, No. 121, 15.02.2012, p. 121ra20.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Wang, Y, Shi, M, Chung, KA, Zabetian, CP, Leverenz, JB, Berg, D, Srulijes, K, Trojanowski, JQ, Lee, VM-Y, Siderowf, AD, Hurtig, H, Litvan, I, Schiess, MC, Peskind, ER, Masuda, M, Hasegawa, M, Lin, X, Pan, C, Galasko, D, Goldstein, DS, Jensen, PH, Yang, H, Cain, KC & Zhang, WJ 2012, 'Phosphorylated α-synuclein in Parkinson's disease', Science Translational Medicine, vol. 4, no. 121, pp. 121ra20. https://doi.org/10.1126/scitranslmed.3002566

APA

Wang, Y., Shi, M., Chung, K. A., Zabetian, C. P., Leverenz, J. B., Berg, D., Srulijes, K., Trojanowski, J. Q., Lee, V. M-Y., Siderowf, A. D., Hurtig, H., Litvan, I., Schiess, M. C., Peskind, E. R., Masuda, M., Hasegawa, M., Lin, X., Pan, C., Galasko, D., ... Zhang, W. J. (2012). Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine, 4(121), 121ra20. https://doi.org/10.1126/scitranslmed.3002566

CBE

Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM-Y, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, Hasegawa M, Lin X, Pan C, Galasko D, Goldstein DS, Jensen PH, Yang H, Cain KC, Zhang WJ. 2012. Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine. 4(121):121ra20. https://doi.org/10.1126/scitranslmed.3002566

MLA

Wang, Yu et al. "Phosphorylated α-synuclein in Parkinson's disease". Science Translational Medicine. 2012, 4(121). 121ra20. https://doi.org/10.1126/scitranslmed.3002566

Vancouver

Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D et al. Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine. 2012 Feb 15;4(121):121ra20. https://doi.org/10.1126/scitranslmed.3002566

Author

Wang, Yu ; Shi, Min ; Chung, Kathryn A ; Zabetian, Cyrus P ; Leverenz, James B ; Berg, Daniela ; Srulijes, Karin ; Trojanowski, John Q ; Lee, Virginia M-Y ; Siderowf, Andrew D ; Hurtig, Howard ; Litvan, Irene ; Schiess, Mya C ; Peskind, Elaine R ; Masuda, Masami ; Hasegawa, Masato ; Lin, Xiangmin ; Pan, Catherine ; Galasko, Douglas ; Goldstein, David S ; Jensen, Poul Henning ; Yang, Hui ; Cain, Kevin C ; Zhang, Wen Jing. / Phosphorylated α-synuclein in Parkinson's disease. In: Science Translational Medicine. 2012 ; Vol. 4, No. 121. pp. 121ra20.

Bibtex

@article{21fbaaf3d8ab41778822b501086e877a,
title = "Phosphorylated α-synuclein in Parkinson's disease",
abstract = "Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total α-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.",
keywords = "Case-Control Studies, Humans, Parkinson Disease, Phosphorylation, alpha-Synuclein",
author = "Yu Wang and Min Shi and Chung, {Kathryn A} and Zabetian, {Cyrus P} and Leverenz, {James B} and Daniela Berg and Karin Srulijes and Trojanowski, {John Q} and Lee, {Virginia M-Y} and Siderowf, {Andrew D} and Howard Hurtig and Irene Litvan and Schiess, {Mya C} and Peskind, {Elaine R} and Masami Masuda and Masato Hasegawa and Xiangmin Lin and Catherine Pan and Douglas Galasko and Goldstein, {David S} and Jensen, {Poul Henning} and Hui Yang and Cain, {Kevin C} and Zhang, {Wen Jing}",
year = "2012",
month = feb,
day = "15",
doi = "10.1126/scitranslmed.3002566",
language = "English",
volume = "4",
pages = "121ra20",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "american association for the advancement of science",
number = "121",

}

RIS

TY - JOUR

T1 - Phosphorylated α-synuclein in Parkinson's disease

AU - Wang, Yu

AU - Shi, Min

AU - Chung, Kathryn A

AU - Zabetian, Cyrus P

AU - Leverenz, James B

AU - Berg, Daniela

AU - Srulijes, Karin

AU - Trojanowski, John Q

AU - Lee, Virginia M-Y

AU - Siderowf, Andrew D

AU - Hurtig, Howard

AU - Litvan, Irene

AU - Schiess, Mya C

AU - Peskind, Elaine R

AU - Masuda, Masami

AU - Hasegawa, Masato

AU - Lin, Xiangmin

AU - Pan, Catherine

AU - Galasko, Douglas

AU - Goldstein, David S

AU - Jensen, Poul Henning

AU - Yang, Hui

AU - Cain, Kevin C

AU - Zhang, Wen Jing

PY - 2012/2/15

Y1 - 2012/2/15

N2 - Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total α-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.

AB - Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total α-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.

KW - Case-Control Studies

KW - Humans

KW - Parkinson Disease

KW - Phosphorylation

KW - alpha-Synuclein

U2 - 10.1126/scitranslmed.3002566

DO - 10.1126/scitranslmed.3002566

M3 - Journal article

C2 - 22344688

VL - 4

SP - 121ra20

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 121

ER -