Poul Henning Jensen

Phosphorylated α-synuclein in Parkinson's disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Yu Wang, Denmark
  • Min Shi
  • ,
  • Kathryn A Chung
  • ,
  • Cyrus P Zabetian
  • ,
  • James B Leverenz
  • ,
  • Daniela Berg
  • ,
  • Karin Srulijes
  • ,
  • John Q Trojanowski
  • ,
  • Virginia M-Y Lee
  • ,
  • Andrew D Siderowf
  • ,
  • Howard Hurtig
  • ,
  • Irene Litvan
  • ,
  • Mya C Schiess
  • ,
  • Elaine R Peskind
  • ,
  • Masami Masuda
  • ,
  • Masato Hasegawa
  • ,
  • Xiangmin Lin
  • ,
  • Catherine Pan
  • ,
  • Douglas Galasko
  • ,
  • David S Goldstein
  • ,
  • Poul Henning Jensen
  • Hui Yang
  • ,
  • Kevin C Cain
  • ,
  • Wen Jing Zhang, Institut for Kemi og Bioteknologi, Denmark
Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total α-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.
Original languageEnglish
JournalScience Translational Medicine
Volume4
Issue121
Pages (from-to)121ra20
ISSN1946-6234
DOIs
Publication statusPublished - 15 Feb 2012

    Research areas

  • Case-Control Studies, Humans, Parkinson Disease, Phosphorylation, alpha-Synuclein

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