Poul Henning Jensen

ELISA method to detect α-synuclein oligomers in cell and animal models

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Soluble aggregates of α-synuclein, so-called oligomers, are hypothesized to act as neurotoxic species in Parkinson's disease, Lewy body dementia and multiple systems atrophy, but specific tools to detect these aggregated species are only slowly appearing. We have developed an α-synuclein oligomer ELISA that allows us to detect and compare α-synuclein oligomer levels in different in vivo and in vitro experiments. The ELISA is based on commercially available antibodies and the epitope of the capture antibody MJF14-6-4-2 is folding- and aggregate-dependent and not present on monomers.

Original languageEnglish
Article numbere0196056
JournalPLOS ONE
Volume13
Issue4
Number of pages12
ISSN1932-6203
DOIs
Publication statusPublished - 26 Apr 2018

    Research areas

  • ACCUMULATION, DEMENTIA, FILAMENTS, IN-VIVO, LEWY BODIES, MULTIPLE SYSTEM ATROPHY, OCCURS, PARKINSONS-DISEASE, PROTEIN, TRANSGENIC MICE

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