Aarhus University Seal / Aarhus Universitets segl

Poul Henning Jensen

Determination of alpha-synuclein concentration in human plasma using ELISA.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Determination of alpha-synuclein concentration in human plasma using ELISA. / Fjorback, A Winther; Varming, K; Jensen, P Henning.

In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 67, No. 4, 2007, p. 431-435.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Fjorback, AW, Varming, K & Jensen, PH 2007, 'Determination of alpha-synuclein concentration in human plasma using ELISA.', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 67, no. 4, pp. 431-435. https://doi.org/10.1080/00365510601161497

APA

Fjorback, A. W., Varming, K., & Jensen, P. H. (2007). Determination of alpha-synuclein concentration in human plasma using ELISA. Scandinavian Journal of Clinical & Laboratory Investigation, 67(4), 431-435. https://doi.org/10.1080/00365510601161497

CBE

Fjorback AW, Varming K, Jensen PH. 2007. Determination of alpha-synuclein concentration in human plasma using ELISA. Scandinavian Journal of Clinical & Laboratory Investigation. 67(4):431-435. https://doi.org/10.1080/00365510601161497

MLA

Fjorback, A Winther, K Varming, and P Henning Jensen. "Determination of alpha-synuclein concentration in human plasma using ELISA.". Scandinavian Journal of Clinical & Laboratory Investigation. 2007, 67(4). 431-435. https://doi.org/10.1080/00365510601161497

Vancouver

Fjorback AW, Varming K, Jensen PH. Determination of alpha-synuclein concentration in human plasma using ELISA. Scandinavian Journal of Clinical & Laboratory Investigation. 2007;67(4):431-435. https://doi.org/10.1080/00365510601161497

Author

Fjorback, A Winther ; Varming, K ; Jensen, P Henning. / Determination of alpha-synuclein concentration in human plasma using ELISA. In: Scandinavian Journal of Clinical & Laboratory Investigation. 2007 ; Vol. 67, No. 4. pp. 431-435.

Bibtex

@article{b8b028e0384e11dd9465000ea68e967b,
title = "Determination of alpha-synuclein concentration in human plasma using ELISA.",
abstract = "The nerve cell protein alpha-synuclein is important in Parkinson's disease and dementia with Lewy bodies, and its expression levels are directly linked to development of the diseases. Quantification of the plasma level of alpha-synuclein may therefore be important as a biomarker for disease susceptibility. We present a quantitative measurement of alpha-synuclein in the plasma of healthy control subjects in relation to their age using a novel enzyme-linked immunosorbent assay (ELISA). The plasma concentration among the 44 blood donors displayed a median of 5.6 microg/L (range 2.1-19.4 microg/L) with a narrow distribution (25 {\%} and 75 {\%} percentiles, 4.0 and 7.2 microg/L) and there was no correlation with age and gender. This narrow concentration range and the ease of measuring the quantitative ELISA support future investigations of plasma alpha-synuclein in relation to neurodegenerative diseases.",
keywords = "Adult, Age Factors, Aged, Analysis of Variance, Animals, Biological Markers, Blood Donors, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Neurodegenerative Diseases, Rabbits, Recombinant Proteins, Reference Values, Sensitivity and Specificity, Sex Factors, alpha-Synuclein",
author = "Fjorback, {A Winther} and K Varming and Jensen, {P Henning}",
year = "2007",
doi = "10.1080/00365510601161497",
language = "English",
volume = "67",
pages = "431--435",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & francis",
number = "4",

}

RIS

TY - JOUR

T1 - Determination of alpha-synuclein concentration in human plasma using ELISA.

AU - Fjorback, A Winther

AU - Varming, K

AU - Jensen, P Henning

PY - 2007

Y1 - 2007

N2 - The nerve cell protein alpha-synuclein is important in Parkinson's disease and dementia with Lewy bodies, and its expression levels are directly linked to development of the diseases. Quantification of the plasma level of alpha-synuclein may therefore be important as a biomarker for disease susceptibility. We present a quantitative measurement of alpha-synuclein in the plasma of healthy control subjects in relation to their age using a novel enzyme-linked immunosorbent assay (ELISA). The plasma concentration among the 44 blood donors displayed a median of 5.6 microg/L (range 2.1-19.4 microg/L) with a narrow distribution (25 % and 75 % percentiles, 4.0 and 7.2 microg/L) and there was no correlation with age and gender. This narrow concentration range and the ease of measuring the quantitative ELISA support future investigations of plasma alpha-synuclein in relation to neurodegenerative diseases.

AB - The nerve cell protein alpha-synuclein is important in Parkinson's disease and dementia with Lewy bodies, and its expression levels are directly linked to development of the diseases. Quantification of the plasma level of alpha-synuclein may therefore be important as a biomarker for disease susceptibility. We present a quantitative measurement of alpha-synuclein in the plasma of healthy control subjects in relation to their age using a novel enzyme-linked immunosorbent assay (ELISA). The plasma concentration among the 44 blood donors displayed a median of 5.6 microg/L (range 2.1-19.4 microg/L) with a narrow distribution (25 % and 75 % percentiles, 4.0 and 7.2 microg/L) and there was no correlation with age and gender. This narrow concentration range and the ease of measuring the quantitative ELISA support future investigations of plasma alpha-synuclein in relation to neurodegenerative diseases.

KW - Adult

KW - Age Factors

KW - Aged

KW - Analysis of Variance

KW - Animals

KW - Biological Markers

KW - Blood Donors

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neurodegenerative Diseases

KW - Rabbits

KW - Recombinant Proteins

KW - Reference Values

KW - Sensitivity and Specificity

KW - Sex Factors

KW - alpha-Synuclein

U2 - 10.1080/00365510601161497

DO - 10.1080/00365510601161497

M3 - Journal article

C2 - 17558898

VL - 67

SP - 431

EP - 435

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 4

ER -