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Poul Henning Jensen

Determination of alpha-synuclein concentration in human plasma using ELISA.

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  • Department of Medical Biochemistry
  • Klinisk Immunologi, Aalborg Sygehus
  • Stereological Research Laboratory
  • Institute of Clinical Medicine
The nerve cell protein alpha-synuclein is important in Parkinson's disease and dementia with Lewy bodies, and its expression levels are directly linked to development of the diseases. Quantification of the plasma level of alpha-synuclein may therefore be important as a biomarker for disease susceptibility. We present a quantitative measurement of alpha-synuclein in the plasma of healthy control subjects in relation to their age using a novel enzyme-linked immunosorbent assay (ELISA). The plasma concentration among the 44 blood donors displayed a median of 5.6 microg/L (range 2.1-19.4 microg/L) with a narrow distribution (25 % and 75 % percentiles, 4.0 and 7.2 microg/L) and there was no correlation with age and gender. This narrow concentration range and the ease of measuring the quantitative ELISA support future investigations of plasma alpha-synuclein in relation to neurodegenerative diseases.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume67
Issue4
Pages (from-to)431-435
Number of pages4
ISSN0036-5513
DOIs
Publication statusPublished - 2007

    Research areas

  • Adult, Age Factors, Aged, Analysis of Variance, Animals, Biological Markers, Blood Donors, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Neurodegenerative Diseases, Rabbits, Recombinant Proteins, Reference Values, Sensitivity and Specificity, Sex Factors, alpha-Synuclein

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