Poul Henning Jensen

  1. 2012
  2. Published

    Effects of chemotherapeutics on organotypic corticostriatal slice cultures identified by a panel of fluorescent and immunohistochemical markers. / Nørregaard, Annette; Jensen, Stine Skov; Kolenda, Jesper; Aaberg-Jessen, Charlotte; Christensen, Karina Garnier; Jensen, Poul Henning; Schrøder, Henrik; Kristensen, Bjarne Winther.

    In: Neurotoxicity Research, Vol. 22, No. 1, 2012, p. 43-58.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    Multiple Roles of Heparin in the Aggregation of p25α. / Nielsen, Søren Bang; Yde, Pernille; Giehm, Lise; Sundbye, Sabrina; Christiansen, Gunna; Matthiesen, Joachim; Jensen, Mogens Høgh; Jensen, Poul Henning; Otzen, Daniel E.

    In: Journal of Molecular Biology, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. 2011
  5. Published

    P25α / TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity. / Fjorback, Anja Nawarecki; Sundbye, Sabrina; Dächsel, Justus C; Sinning, Steffen; Wiborg, Ove; Jensen, Poul H.

    In: F E B S Journal, Vol. 278, No. 3, 01.02.2011, p. 493-505.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Direct MRI-guided stereotaxic viral mediated gene transfer of alpha-synuclein in the Gottingen minipig CNS. / GLUD, AN; Hedegaard, Claus; Nielsen, Mette Slot; Sorensen, Jens Christian; Bendixen, Christian; Jensen, Poul Henning; Mogensen, Poul Henning; Larsen, Knud ; Bjarkam, Carsten Reidies.

    In: Acta Neurobiologiae Experimentalis, Vol. 71, No. 4, 2011, p. 508-518.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Direct MRI-guided stereotaxic viral mediated gene transfer of alphasynuclein in the Göttingen minipig CNS. / Jensen, Poul Henning.

    In: Acta Neurobiologiae Experimentalis, Vol. 71, No. 4, 2011, p. 508-518.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. 2010
  9. Published

    Presymptomatic intranuclear inclusion body disease in a 78-year-old female. / Mori, F.; Miki, Y.; Ogura, E.; Yagihashi, N.; Jensen, Poul Henning; Wakabayashi, K.

    In: Neuropathology, Vol. epub ahead of print, 27.07.2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. / Ulusoy, Ayse; Febbraro, Fabia; Jensen, Poul H; Kirik, Deniz; Romero-Ramos, Marina.

    In: European Journal of Neuroscience, Vol. 32, No. 3, 2010, p. 409-22.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    DJ-1 and {alpha}-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. / Hong, Z; Shi, M; Chung, KA; Quinn, JF; Peskind, ER; Galasko, D; Jankovic, J; Zabetian, CP; Leverenz, JB; Baird, G; Montine, TJ; Hancock, AM; Hwang, H; Pan, C; Bradner, J; Kang, UJ; Jensen, Poul Henning; Zhang, J.

    In: Brain, Vol. 133, 2010, p. 713-726.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Direct gene transfer in the Gottingen minipig CNS using stereotaxic lentiviral microinjections. / GLUD, AN; Hedegaard, Claus; nielsen, MS; Sørensen, Jens Christian H.; Bendixen, Christian; Jensen, Poul Henning; Larsen, Knud Erik; Bjarkam, Carsten Reidies.

    In: Acta Neurobiologiae Experimentalis, Vol. 70, No. 3, 2010, p. 308-315.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Direct gene transfer in the Gottingen minipig CNS using stereotaxic lentiviral microinjections. / GLUD, AN; Hedegaard, Claus; Nielsen, Mette Slot; Sørensen, Jens Christian; Bendixen, Christian; Jensen, Poul Henning; Larsen, Knud; Bjarkam, Carsten Reidies.

    In: Acta Neurobiologiae Experimentalis, Vol. 70, No. 3, 2010, p. 308-15.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Direct viral mediated gene transfer in substantia nigra of the Göttingen minipig induced by MRI-guided stereotaxic microinjections of lentiviral vectors encoding alpha synuclein controlled bý gait analysis. / Glud, Andreas Nørgaard; Hedegaard, Claus; Nielsen, Mette Slot; Larsen, Knud Erik; Mogensen, Poul; Sørensen, Jens Christian H.; Bendixen, Christian; Jensen, Poul Henning; Bjarkam, Carsten Reidies.

    2010. Poster session presented at 62nd Annual Congress of the Scandinavian Neurosurgical Society, .

    Research output: Contribution to conferencePosterResearch

  15. 2009
  16. Published

    An Exonic Insertion Encodes an Alanine Stretch in Porcine Synapsin I. / Hedegaard, Claus; Bendixen, Emøke; Jensen, Poul Henning; Bendixen, Christian; Larsen, Knud.

    In: Biochemical Genetics, Vol. 47, No. 11-12, 2009, p. 812-816.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Elevated levels of soluble α-synuclein oligomers in the dementia with Lewy bodies brains. / Paleologou, K.E.; Salem, S.A.; Al-Shami, R.; Mann, D.M.A.; Allsop, D.; Hassan, S.A.E.; Kragh, Christine Lund; Jensen, Poul Henning; El-Agnaf, O.M.A.

    In: Brain, Vol. 132, 2009, p. 1093-1101.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Novel proteins in α-synucleinopathies. / Kragh, Christine Lund; Jensen, Poul Henning.

    Focus on Structural Biology: Protein folding and misfolding: Neurodegenerative diseases. Vol. 7 Springer Science+Business Media, 2009. p. 207-224 (Focus on Structural Biology, Vol. 7).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearch

  19. Published

     Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration? / Kirik, Deniz; Gai, Wei-Ping; Jensen, Poul Henning.

    In: Experimental Neurology, Vol. 209, 2009, p. 3-4.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  20. Published

    α-synuclein aggregation and Ser129 phosphorylation dependent cell death in oligodendroglial cells. / Kragh, Christine Lund; Lund, Louise Buur; Febbraro, Fabia; Hansen, Hanne Demant; Gai, W.P.; Richter-Landsberg, C.; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, Vol. 284, 2009, p. 10211-10222.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. 2008
  22. Published

    Peroxiredoxin 6 in human brain: Molecular forms, cellular distribution and association with Alzheimer's disease pathology. / Power, J.H.T.; Asad, S.; Chataway, T.K.; Chegini, F.; Manavis, J.; Temlett, J.A.; Jensen, Poul Henning; Blumbergs, P.C.; Gai, W.P.

    In: Acta Neuropathologica, Vol. 115, 2008, p. 611-622.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    The expression of tubulin polymerization promoting protein TPPP/p25α is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress. / Goldbaum, O.; Jensen, Poul Henning; Richter-Landsberg, C.

    In: Glia, Vol. 56, 2008, p. 1736-1746.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

     Identification of multiple posttranslational modifications in the porcine brain specific p25α. / Kleinnijenhuis, A.J.; Hedegaard, C.; Lundvig, Ditte Maria Simonsen; Sundbye, Sabrina; Issinger, O.G.; Nørregaard Jensen, O.; Jensen, Poul Henning.

    In: Journal of Neurochemistry, Vol. 1006, 2008, p. 925-933.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. 2007
  26. Published

    Determination of alpha-synuclein concentration in human plasma using ELISA. / Fjorback, A Winther; Varming, K; Jensen, P Henning.

    In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 67, No. 4, 2007, p. 431-435.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    P25α relocalizes in oligodendroglia from myelin to glial cytoplasmic inclusions in multiple system atrophy. / Song, Y.J.; Lundvig, D.M.S.; Huang, Y.; Gai, W.P.; Blumbergs, P.C.; Højrup, P.; Otzen, P.; Halliday, G.M.; Jensen, Poul Henning.

    In: American Journal of Pathology, Vol. 171, 2007, p. 1291-1303.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. 2006
  29. Published

    Association of alpha-Synuclein and Mutants with Lipid Membranes: Spin-Label ESR and Polarized IR. / Ramakrishnan, M.; Jensen, Poul Henning; Marsh, D.

    In: Biochemistry, Vol. 45, 2006, p. 3386-3395.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Cellular parkin mutants are soluble under non-stress conditions. / Jensen, Lene Diness; Jensen, Tua Vinther; Kahns, Søren; Sundbye, Sabrina; Jensen, Poul Henning.

    In: NeuroReport, Vol. 17, 2006, p. 1205-1208.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Oligodendrocytes within astrocytes ("emperipolesis") in the cerebral white matter in hepatic and hypoglycemic encephalopathy. / Nishie, M.; Mori, F.; Houzen, H.; Yamaguci, J.; Jensen, Poul Henning; Wakabayashi, K.

    In: Biochemistry, Vol. 26, 2006, p. 62-65.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    P25alpha immunoreactive but alpha-synuclein immunonegative neuronal inclusions in multiple system atrophy. / Baker, K.G.; Huang, Yue; McCann, H.; Gai, Wei Ping; Jensen, Poul Henning; Halliday, Glenda.

    In: Acta Neuropathologica, Vol. 111, 2006, p. 193-195.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. / Skjørringe, T.; Lundvig, Ditte Maria Simonsen; Jensen, Poul Henning; Moos, Torben.

    In: Journal of Neurochemistry, Vol. 99, No. 1, 2006, p. 333-342.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2005
  35. Published

    P25a stimulate α-synuclein aggregation and is colocalized with aggregated α-synuclein in α-synucleinopathies. / Lindersson, Evo; Lundvig, Ditte Maria Simonsen; Madsen, Peder Søndergaard; Gai, W.-P.; Højrup, P.; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, Vol. 280, 2005, p. 5703-5715.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    P25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry. / Otzen, D.E.; Lundvig, Ditte Maria Simonsen; Wimmer, R.; Nielsen, L.H.; Pedersen, J.R.; Jensen, Poul Henning.

    In: Protein Sci., Vol. 14, 2005, p. 1396-1409.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    Pathogenic effects of α-synuclein aggregation. / Lundvig, Ditte Maria Simonsen; Linderson, E.; Jensen, Poul Henning.

    In: Molecular Brain Research, Vol. 134, No. 1, 2005, p. 3-16.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson’s disease. / Noda, K.; Kitami, T.; Gai, W.-P.; Chegini, F.; Jensen, Poul Henning; Fujimura, T.; Murayama, K.; Tanaka, K.; Mizuno, Y.; Hattori, N.

    In: Biochem. Biophys. Res. Com., Vol. 331, 2005, p. 309-317.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    p25α Stimulates α-Synuclein Aggregation and Is Co-localized with Aggregated α-Synuclein in α-Synucleinopathies. / Lindersson, Evo Kristina; Lundvig, Ditte Maria Simonsen; Petersen, Christine; Madsen, Peder; Nyengaard, Jens Randel; Højrup, Peter; Moos, Torben; Otzen, Daniel ; Gai, Wei-Ping; Blumbergs, Peter C.; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, Vol. 280, 2005, p. 5703-5715.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    p25α is flexible but natively folded and binds tubulin with oligomeric stoichiometry. / Otzen, Daniel E. ; Lundvig, Ditte Maria Simonsen; Wimmer, Reinhard; Nielsen, Lotte Hatting; Pedersen, Jakob R.; Jensen, Poul Henning.

    In: Protein Science, Vol. 14, No. 6, 2005, p. 1396-1409.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. Published

    α-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson’s disease. / Halliday, G.M.; Ophof, A.; Broe, M.; Jensen, Poul Henning; Kettle, E.; Fedorow, H.; Cartwright, M.I.; Griffiths, F.M.; Shepherd, C.E.; Double, K.L.

    In: Brain, Vol. 128, 2005, p. 2654-2664.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. 2004
  43. Published

    Absence of prostate apoptosis response-4 (Par-4) protein in parkinsons disease autopsies. / Moos, T.; Jensen, Poul Henning; Mattson, M.P.

    In: Acta Neuropathol, Vol. 1007, 2004, p. 23-26.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  44. Published

    Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain. / Lowe, R.; Pountney, D.L.; Jensen, Poul Henning; Gai, W.-P.; Voelcker, N.

    In: Protein Sci., Vol. 13, 2004, p. 3245-3252.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  45. Published

    Endogenous parkin is recruited into aggresomes in a stress-specific manner: over-exposure of parkin reduces aggresome formation but can be dissociated from parkins effect on neuronal survival. / Muqit, M.K.; Davidson, S.M.; Payne-Smith, M.D.; MacCormac, L.P.; Kahns, Søren; Jensen, Poul Henning; Wood, N.W.; Latchman, D.S.

    In: Hum Mol Genet, Vol. 13, 2004, p. 117-135.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  46. Published

    Natively unfolded tubulin polymeration promoting protein TPPP/p25 is a common marker of á-synucleinopathies. / Kovács, G.G.; László, L.; Kovács, J.; Jensen, Poul Henning; Lindersson, E.; Botond, G.; Molnár, T.; Perczel, A.; Hudecz, F.; Mezö, G.; Erdei, A.; Tirián, L.; Lehotzky, A.; Gelpi, E.; Budka, H.; Ovádi, J.

    In: Neurobiol. Dis., Vol. 17, 2004, p. 155-162.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  47. Published

    Proteasomal inhibition by a á-synuclein filaments and oligomers. / Lindersson, E.; Beedholm, Rasmus; Højrup, P.; Moos, T.; Gai, W.-P.; Hendil, K.B.; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, Vol. 279, 2004, p. 12924-12934.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  48. Published

    Proteasomal inhibition by alpha-synuclein filaments and oligomers. / Lindersson, Evo; Beedholm, Rasmus; Højrup, Peter; Moos, Torben; Gai, WeiPing; Hendil, Klavs B; Jensen, Poul H.

    In: Journal of Biological Chemistry, Vol. 279, No. 13, 2004, p. 12924-34.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    α-synuclein filaments bind the transcriptional activator HMGB-1. / Lindersson, E.; Højrup, P.; Gai, W.-P.; Locker, D.; Martin, D.; Jensen, Poul Henning.

    In: J Neuroreport, Vol. 15, 2004, p. 2735-2739.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  50. 2003
  51. Published

    Alpha-Synuclein association with phosphatidylglycerol probed by spin labels. / Ramakrishnan, M.; Jensen, Poul Henning; March, D.

    In: Biochemistry, No. 42, 2003, p. 12919-12926.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  52. Published

    Alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy. / Gai, W.P.; Pountney, D.L.; Power, J.H.T.; Li, Q.X.; Culvenor, J.G.; McLean, C.A.; Jensen, Poul Henning; Blumbergs, P.C.

    In: Exp. Neurol, No. 181, 2003, p. 68-78.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  53. Published

    Caspase-1 and caspase-8 cleave and inactive cellular parkin. / Kahns, Søren; Kalai, M.; Jakobsen, L.D.; Clark, Brian Frederic Carl; Vandenabeele, P.; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, No. 278, 2003, p. 23376-23380.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  54. Published

    Parkinsons disease - alpha-synuclein and parkin in protein aggregation and the reversal of unfolded protein stress. / Jakobsen, L.D.; Jensen, Poul Henning.

    In: Methods Mol Biol., No. 232, 2003, p. 57-66.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  55. 2002
  56. Published

    Alpha-synuclein and presynaptic function: Implications for Parkinson's disease. / Lykkebo, S.; Jensen, Poul Henning.

    In: Neuromolecular Med, Vol. 2, 2002, p. 115-129.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  57. Published

    Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress. / Ledesma, M.D.; Galvan, C.; Hellias, B.; Dotti, C.; Jensen, Poul Henning.

    In: J. Neurochem, Vol. 83, 2002, p. 1431-1440.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  58. Published

    Caspase-mediated parkin cleavage in apoptotic cell death. / Kahns, Søren; Lykkebo, S.; Jakobsen, L.D.; Nielsen, Morten Schallburg; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, Vol. 277, 2002, p. 15303-15308.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  59. Published

    Differential localization of alpha-, beta- and gamma-synucleins in the rat central nervous system. / Li, J.-Y.; Jensen, Poul Henning; Dahlström, A.

    In: Neuroscience, Vol. 113, 2002, p. 463-478.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  60. Published

    Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? / Mengesdorf, T.; Jensen, Poul Henning; Mies, G.; Aufenberg, C.; Paschen, W.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, 2002, p. 15042-15047.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  61. 2001
  62. Published

    Ca2+ binding to α-synuclein regulates ligand binding and oligomerization. / Nielsen, Morten Schallburg; Vorum, Henrik; Lindersson, E.; Jensen, Poul Henning.

    In: Journal of Biological Chemistry, Vol. 276, 2001, p. 22680-22684.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch