Poul Henning Jensen

  1. 2022
  2. Published

    Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers. / Alam, Parvez; Holst, Mikkel R; Lauritsen, Line et al.

    In: Fluids and Barriers of the CNS, Vol. 19, No. 1, 30.05.2022, p. 37.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. / Ghanem, Simona S.; Majbour, Nour K.; Vaikath, Nishant N. et al.

    In: PNAS (Proceedings of the National Academy of Sciences of the United States of America), Vol. 119, No. 15, e2109617119, 04.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. / Reimer, Lasse; Haikal, Caroline; Gram, Hjalte et al.

    In: Scientific Reports, Vol. 12, 3737, 03.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Recombinant adeno-associated virus mediated gene delivery in the extracranial nervous system of adult mice by direct nerve immersion. / Richner, Mette; Gonçalves, Nádia Pereira; Jensen, Poul Henning et al.

    In: STAR Protocols, Vol. 3, No. 1, 101181, 03.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. E-pub ahead of print

    Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models. / Mavroeidi, Panagiota; Arvanitaki, Fedra; Vetsi, Maria et al.

    In: Autophagy, 09.01.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. 2021
  8. Published

    Alpha-synuclein research : defining strategic moves in the battle against Parkinson's disease. / Oliveira, Luis M A; Gasser, Thomas; Edwards, Robert et al.

    In: npj Parkinson's Disease, Vol. 7, No. 1, 65, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  9. Published

    Endoplasmic Reticulum-Based Calcium Dysfunctions in Synucleinopathies. / Kovacs, Gergo; Reimer, Lasse; Jensen, Poul Henning.

    In: Frontiers in Neurology, Vol. 12, 742625, 10.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  10. Published

    Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein. / Elfarrash, Sara; Jensen, Nanna Møller; Ferreira, Nelson et al.

    In: PLOS ONE, Vol. 16, No. 10, e0252635, 10.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy. / Cui, Hengjing; Kilpeläinen, Tommi; Zouzoula, Lydia et al.

    In: Journal of Cellular and Molecular Medicine, Vol. 25, No. 20, 10.2021, p. 9634-9646.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity. / Gregersen, Emil; Betzer, Cristine; Kim, Woojin S et al.

    In: Journal of Neuroinflammation, Vol. 18, 177, 08.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo. / Vecchio, Laura M; Sullivan, Patricia; Dunn, Amy R et al.

    In: Journal of Neurochemistry, Vol. 158, No. 4, 08.2021, p. 960-979.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease : Update on Models and Hypotheses. / Jan, Asad; Gonçalves, Nádia Pereira; Vaegter, Christian Bjerggaard et al.

    In: International Journal of Molecular Sciences , Vol. 22, No. 15, 8338, 08.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  15. Published

    Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential. / Ferreira, Nelson; Gram, Hjalte; Sorrentino, Zachary A et al.

    In: Acta Neuropathologica, Vol. 142, 07.2021, p. 87-115.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats. / Van Den Berge, Nathalie; Ferreira, Nelson; Mikkelsen, Trine Werenberg et al.

    In: Brain : a journal of neurology, Vol. 144, No. 6, 06.2021, p. 1853–1868.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. / Delaidelli, Alberto; Richner, Mette; Jiang, Lixiang et al.

    In: Acta Neuropathologica Communications, Vol. 9, No. 1, 105, 06.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Organotypic hippocampal slices, an emerging tool to model synucleinopathies. / Elfarrash, Sara; Jensen, Poul Henning.

    In: Neural Regeneration Research, Vol. 16, No. 5, 05.2021, p. 999-1000.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperEditorialResearchpeer-review

  19. Published

    Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy. / Ferreira, Nelson; Richner, Mette; van der Laan, Amelia et al.

    In: Brain Communications, Vol. 3, No. 2, fcab104, 05.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Multiple Protective Roles of Nanoliposome-Incorporated Baicalein against Alpha-Synuclein Aggregates. / Aliakbari, Farhang; Mohammad-Beigi, Hossein; Abbasi, Shahsanam et al.

    In: Advanced Functional Materials, Vol. 31, No. 7, 2007765, 10.02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats. / Thomsen, Majken B; Ferreira, Sara A; Schacht, Anna C et al.

    In: Neurobiology of Disease, Vol. 149, 105229, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. / Ferreira, Nelson; Gonçalves, Nádia Pereira; Jan, Asad et al.

    In: Acta Neuropathologica Communications, Vol. 9, 31, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    PKR kinase directly regulates tau expression and Alzheimer's Disease-related tau phosphorylation. / Reimer, Lasse; Betzer, Cristine; Kofoed, Rikke Hahn et al.

    In: Brain Pathology, Vol. 31, No. 1, 01.2021, p. 103-119.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. 2020
  25. Published

    Glycogen synthase kinase 3 β activity is essential for Polo-like kinase 2- and Leucine-rich repeat kinase 2-mediated regulation of α-synuclein. / Kofoed, Rikke H; Betzer, Cristine; Ferreira, Nelson et al.

    In: Neurobiology of Disease, Vol. 136, 104720, 03.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. / Juul-Madsen, Kristian; Qvist, Per; Bendtsen, Kirstine L et al.

    In: Journal of Immunology, Vol. 204, No. 5, 2020, p. 1345-1361.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. 2019
  28. Published

    Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates. / Elfarrash, Sara; Jensen, Nanna Møller; Ferreira, Nelson et al.

    In: Acta Neuropathologica Communications, Vol. 7, No. 1, 213, 19.12.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model : Findings and Implications. / Andersen, Michael Aagaard; Sotty, Florence; Jensen, Poul Henning et al.

    In: eNeuro , Vol. 6, No. 6, 07.11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. / Hsiao, Jen Hsiang T.; Purushothuman, Sivaraman; Jensen, Poul H. et al.

    In: Frontiers in Neuroscience, Vol. 13, 1187, 01.11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Gene Transfer in Rodent Nervous Tissue Following Hindlimb Intramuscular Delivery of Recombinant Adeno-Associated Virus Serotypes AAV2/6, AAV2/8, and AAV2/9. / Asad, Jan; Richner, Mette; Vægter, Christian Bjerggaard et al.

    In: Neuroscience Insights, Vol. 14, No. November-December, 11.2019, p. 1-12.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Correction to : Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. / Mavroeidi, Panagiota; Arvanitaki, Fedra; Karakitsou, Anastasia-Kiriaki et al.

    In: Acta Neuropathologica, Vol. 138, No. 4, 10.2019, p. 675.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats. / Van Den Berge, Nathalie; Ferreira, Nelson; Gram, Hjalte et al.

    In: Acta Neuropathologica, Vol. 138, No. 4, 10.2019, p. 535-550.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. Published

    Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. / Mavroeidi, Panagiota; Arvanitaki, Fedra; Karakitsou, Anastasia-Kiriaki et al.

    In: Acta Neuropathologica, Vol. 138, No. 3, 09.2019, p. 415-441.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  35. Published

    Stabilization of α-synuclein oligomers using formaldehyde. / Ruesink, Harm; Reimer, Lasse; Gregersen, Emil et al.

    In: PLOS ONE, Vol. 14, No. 10, e0216764, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    The use of co-immunoprecipitation to study conformation-specific protein interactions of oligomeric α-synuclein aggregates. / Betzer, Cristine; Kofoed, Rikke Hahn; Jensen, Poul Henning.

    Neuromethods : co-immunoprecipitation methods for brain tissue. New York : Humana Press, 2019. p. 23-36 (Neuromethods, Vol. 144).

    Research output: Contribution to book/anthology/report/proceedingBook chapterEducationpeer-review

  37. 2018
  38. Published

    Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies. / Betzer, Cristine; Jensen, Poul Henning.

    In: Frontiers in Neuroscience, Vol. 12, 819, 06.11.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  39. Published

    Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. / Andersen, Michael Aagaard; Christensen, Kenneth Vielsted; Badolo, Lassina et al.

    In: Neurobiology of Disease, Vol. 116, 08.2018, p. 13-27.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome : A pilot study. / PARS Investigators.

    In: Neurobiology of Disease, Vol. 116, 08.2018, p. 53-59.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. Published

    Commentary: Alpha-Synuclein Aggregates Cause Calcium Dysregulation by Activating Calcium Pump SERCA. / Betzer, Cristine; Jensen, Poul Henning.

    In: J. Neurology Neuromedicine, Vol. 3, No. 4, 06.07.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  42. Published

    Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation. / Kofoed, Rikke H; Betzer, Cristine; Lykke-Andersen, Søren et al.

    In: Journal of Visualized Experiments, No. 135, 03.05.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation. / Betzer, Cristine; Lassen, Louise Berkhoudt; Olsen, Anders et al.

    In: EMBO Reports, Vol. 19, No. 5, e44617, 01.05.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death. / Reimer, Lasse; Lund, Louise Buur; Betzer, Cristine et al.

    In: Neurobiology of Disease, 01.05.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    ELISA method to detect α-synuclein oligomers in cell and animal models. / Lassen, Louise Berkhoudt; Gregersen, Emil; Isager, Anne Kathrine et al.

    In: PLOS ONE, Vol. 13, No. 4, e0196056, 26.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats. / Andersen, Michael Aagaard; Wegener, Karen Malene; Larsen, Steen et al.

    In: Toxicology, Vol. 395, 15.02.2018, p. 15-22.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology. / Olesen, Mads N.; Christiansen, Josefine R.; Petersen, Steen Vang et al.

    In: Heliyon, Vol. 4, No. 1, e00513, 11.01.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. Published

    A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. / Wang, Hua; Stewart, Tessandra; Toledo, Jon B et al.

    In: Journal of Alzheimer's Disease, Vol. 61, No. 4, 2018, p. 1541-1553.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. / Jan, Asad; Jansonius, Brandon; Delaidelli, Alberto et al.

    In: Acta Neuropathologica Communications, Vol. 6, No. 1, 54, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. / Shi, Min; Tang, Lu; Toledo, Jon B et al.

    In: Alzheimer's & Dementia, Vol. 14, No. 8, 2018, p. 1052-1062.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. Published

    Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. / Walsh, Ryan R; Krismer, Florian; Galpern, Wendy R et al.

    In: Neurology, Vol. 90, No. 2, 2018, p. 74-82.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  52. 2017
  53. Published

    Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production. / Kofoed, Rikke H; Zheng, Jin; Ferreira, Nelson et al.

    In: Neurobiology of Disease, Vol. 106, 17.10.2017, p. 49-62.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. Published

    SOLUBLE AGGREGATES OF ALPHA-SYNUCLEIN ACTIVATE SERCA CAUSING CALCIUM DYSREGULATION. / Betzer, Cristine; Lassen, Louise Berkhoudt; Möller, Arne et al.

    2017. Poster session presented at 20 years of alpha-synuclein in Parkinson's disease and related synucleinopathies, Greece.

    Research output: Contribution to conferencePosterResearch

  55. Published

    SOLUBLE AGGREGATES OF ALPHA-SYNUCLEIN ACTIVATES SERCA CAUSING CALCIUM DYSREGULATION. / Betzer, Cristine; Lassen, Louise Berkhoudt; Möller, Arne et al.

    2017. Poster session presented at AD/PD 2017 , Vienna, Austria.

    Research output: Contribution to conferencePosterResearch

  56. 2016
  57. Published

    The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins. / Yatime, Laure; Betzer, Cristine; Jensen, Rasmus Kjeldsen et al.

    In: Structure, Vol. 24, No. 12, 06.12.2016, p. 2043-2052.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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