Poul Henning Jensen

  1. 2022
  2. Published

    α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. / Ghanem, Simona S.; Majbour, Nour K.; Vaikath, Nishant N.; Ardah, Mustafa T.; Erskine, Daniel; Jensen, Nanna Møller; Fayyad, Muneera; Sudhakaran, Indulekha P.; Vasili, Eftychia; Melachroinou, Katerina; Abdi, Ilham Y.; Poggiolini, Ilaria; Santos, Patricia; Dorn, Anton; Carloni, Paolo; Vekrellis, Kostas; Attems, Johannes; McKeith, Ian; Outeiro, Tiago F.; Jensen, Poul Henning; El-Agnaf, Omar M.A.

    In: PNAS (Proceedings of the National Academy of Sciences of the United States of America), Vol. 119, No. 15, e2109617119, 04.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    Recombinant adeno-associated virus mediated gene delivery in the extracranial nervous system of adult mice by direct nerve immersion. / Richner, Mette; Gonçalves, Nádia Pereira; Jensen, Poul Henning; Nyengaard, Jens Randel; Vægter, Christian Bjerggaard; Jan, Asad.

    In: STAR Protocols, Vol. 3, No. 1, 101181, 18.03.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. / Reimer, Lasse; Haikal, Caroline; Gram, Hjalte; Theologidis, Vasileios; Kovacs, Gergo; Ruesink, Harm; Baun, Andreas; Nielsen, Janni; Otzen, Daniel Erik; Li, Jia-Yi; Jensen, Poul Henning.

    In: Scientific Reports, Vol. 12, 3737, 03.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. E-pub ahead of print

    Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models. / Mavroeidi, Panagiota; Arvanitaki, Fedra; Vetsi, Maria; Becker, Stefan; Vlachakis, Dimitrios; Jensen, Poul Henning; Stefanis, Leonidas; Xilouri, Maria.

    In: Autophagy, 09.01.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2021
  7. Published

    Alpha-synuclein research : defining strategic moves in the battle against Parkinson's disease. / Oliveira, Luis M A; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A; Sulzer, David; Vekrellis, Kostas; Halliday, Glenda M; Tomlinson, Julianna J; Schlossmacher, Michael; Jensen, Poul Henning; Schulze-Hentrich, Julia; Riess, Olaf; Hirst, Warren D; El-Agnaf, Omar; Mollenhauer, Brit; Lansbury, Peter; Outeiro, Tiago F.

    In: npj Parkinson's Disease, Vol. 7, No. 1, 65, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  8. Published

    Endoplasmic Reticulum-Based Calcium Dysfunctions in Synucleinopathies. / Kovacs, Gergo; Reimer, Lasse; Jensen, Poul Henning.

    In: Frontiers in Neurology, Vol. 12, 742625, 10.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  9. Published

    Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein. / Elfarrash, Sara; Jensen, Nanna Møller; Ferreira, Nelson; Schmidt, Sissel Ida; Gregersen, Emil; Vestergaard, Marie Vibeke; Nabavi, Sadegh; Meyer, Morten; Jensen, Poul Henning.

    In: PLOS ONE, Vol. 16, No. 10, e0252635, 10.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy. / Cui, Hengjing; Kilpeläinen, Tommi; Zouzoula, Lydia; Auno, Samuli; Trontti, Kalevi; Kurvonen, Sampo; Norrbacka, Susanna; Hovatta, Iiris; Jensen, Poul Henning; Myöhänen, Timo T.

    In: Journal of Cellular and Molecular Medicine, Vol. 25, No. 20, 10.2021, p. 9634-9646.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity. / Gregersen, Emil; Betzer, Cristine; Kim, Woojin S; Kovacs, Gergo; Reimer, Lasse; Halliday, Glenda M; Thiel, Steffen; Jensen, Poul Henning.

    In: Journal of Neuroinflammation, Vol. 18, 177, 08.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo. / Vecchio, Laura M; Sullivan, Patricia; Dunn, Amy R; Bermejo, Marie Kristel; Fu, Rong; Masoud, Shababa T; Gregersen, Emil; Urs, Nikhil M; Nazari, Reza; Jensen, Poul Henning; Ramsey, Amy; Goldstein, David S; Miller, Gary W; Salahpour, Ali.

    In: Journal of Neurochemistry, Vol. 158, No. 4, 08.2021, p. 960-979.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease : Update on Models and Hypotheses. / Jan, Asad; Gonçalves, Nádia Pereira; Vaegter, Christian Bjerggaard; Jensen, Poul Henning; Ferreira, Nelson.

    In: International Journal of Molecular Sciences , Vol. 22, No. 15, 8338, 08.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  14. Published

    Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential. / Ferreira, Nelson; Gram, Hjalte; Sorrentino, Zachary A; Gregersen, Emil; Schmidt, Sissel Ida; Reimer, Lasse; Betzer, Cristine; Perez-Gozalbo, Clara; Beltoja, Marjo; Nagaraj, Madhu; Wang, Jie; Nowak, Jan S; Dong, Mingdong; Willén, Katarina; Cholak, Ersoy; Bjerregaard-Andersen, Kaare; Mendez, Nicolas; Rabadia, Prakruti; Shahnawaz, Mohammad; Soto, Claudio; Otzen, Daniel E; Meyer, Morten; Giasson, Benoit I; Romero-Ramos, Marina; Jensen, Poul Henning.

    In: Acta Neuropathologica, Vol. 142, 07.2021, p. 87-115.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats. / Van Den Berge, Nathalie; Ferreira, Nelson; Mikkelsen, Trine Werenberg; Alstrup, Aage Kristian Olsen; Tamgüney, Gültekin; Karlsson, Páll; Terkelsen, Astrid Juhl; Nyengaard, Jens Randel; Jensen, Poul Henning; Borghammer, Per.

    In: Brain : a journal of neurology, Vol. 144, No. 6, 06.2021, p. 1853–1868.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. / Delaidelli, Alberto; Richner, Mette; Jiang, Lixiang; van der Laan, Amelia; Bergholdt Jul Christiansen, Ida; Ferreira, Nelson; Nyengaard, Jens R; Vægter, Christian B; Jensen, Poul H; Mackenzie, Ian R; Sorensen, Poul H; Jan, Asad.

    In: Acta Neuropathologica Communications, Vol. 9, No. 1, 105, 06.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Organotypic hippocampal slices, an emerging tool to model synucleinopathies. / Elfarrash, Sara; Jensen, Poul Henning.

    In: Neural Regeneration Research, Vol. 16, No. 5, 05.2021, p. 999-1000.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperEditorialResearchpeer-review

  18. Published

    Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy. / Ferreira, Nelson; Richner, Mette; van der Laan, Amelia; Bergholdt Jul Christiansen, Ida; Vægter, Christian B; Nyengaard, Jens R; Halliday, Glenda M; Weiss, Joachim; Giasson, Benoit I; Mackenzie, Ian R; Jensen, Poul H; Jan, Asad.

    In: Brain Communications, Vol. 3, No. 2, fcab104, 05.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    Multiple Protective Roles of Nanoliposome-Incorporated Baicalein against Alpha-Synuclein Aggregates. / Aliakbari, Farhang; Mohammad-Beigi, Hossein; Abbasi, Shahsanam; Rezaei-Ghaleh, Nasrollah; Lermyte, Frederik; Parsafar, Soha; Becker, Stefan; Tafreshi, Azita Parvaneh; O'Connor, Peter B.; Collingwood, Joanna F.; Christiansen, Gunna; Sutherland, Duncan S.; Jensen, Poul Henning; Morshedi, Dina; Otzen, Daniel E.

    In: Advanced Functional Materials, Vol. 31, No. 7, 2007765, 10.02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats. / Thomsen, Majken B; Ferreira, Sara A; Schacht, Anna C; Jacobsen, Jan; Simonsen, Mette; Betzer, Cristine; Jensen, Poul H; Brooks, David J; Landau, Anne M; Romero-Ramos, Marina.

    In: Neurobiology of Disease, Vol. 149, 105229, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. / Ferreira, Nelson; Gonçalves, Nádia Pereira; Jan, Asad; Jensen, Nanna Møller; van der Laan, Amelia; Mohseni, Simin; Vægter, Christian Bjerggaard; Jensen, Poul Henning.

    In: Acta Neuropathologica Communications, Vol. 9, 31, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    PKR kinase directly regulates tau expression and Alzheimer's Disease-related tau phosphorylation. / Reimer, Lasse; Betzer, Cristine; Kofoed, Rikke Hahn; Volbracht, Christiane; Fog, Karina; Kurhade, Chaitanya; Nilsson, Emma; Överby, Anna K; Jensen, Poul Henning.

    In: Brain Pathology, Vol. 31, No. 1, 01.2021, p. 103-119.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. 2020
  24. Published

    Glycogen synthase kinase 3 β activity is essential for Polo-like kinase 2- and Leucine-rich repeat kinase 2-mediated regulation of α-synuclein. / Kofoed, Rikke H; Betzer, Cristine; Ferreira, Nelson; Jensen, Poul Henning.

    In: Neurobiology of Disease, Vol. 136, 104720, 03.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. / Juul-Madsen, Kristian; Qvist, Per; Bendtsen, Kirstine L; Langkilde, Annette E; Vestergaard, Bente; Howard, Ken; Dehesa-Etxebeste, Martxel; Paludan, Søren R; Andersen, Gregers Rom; Jensen, Poul Henning; Otzen, Daniel E; Romero-Ramos, Marina; Vorup-Jensen, Thomas.

    In: Journal of Immunology, Vol. 204, No. 5, 2020, p. 1345-1361.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. 2019
  27. Published

    Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates. / Elfarrash, Sara; Jensen, Nanna Møller; Ferreira, Nelson; Betzer, Cristine; Thevathasan, Jervis Vermal; Diekmann, Robin; Adel, Mohamed; Omar, Nisreen Mansour; Boraie, Mohamed Z; Gad, Sabry; Ries, Jonas; Kirik, Deniz; Nabavi, Sadegh; Jensen, Poul Henning.

    In: Acta Neuropathologica Communications, Vol. 7, No. 1, 213, 19.12.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model : Findings and Implications. / Andersen, Michael Aagaard; Sotty, Florence; Jensen, Poul Henning; Badolo, Lassina; Jeggo, Ross; Smith, Garrick Paul; Christensen, Kenneth Vielsted.

    In: eNeuro , Vol. 6, No. 6, 07.11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. / Hsiao, Jen Hsiang T.; Purushothuman, Sivaraman; Jensen, Poul H.; Halliday, Glenda M.; Kim, Woojin Scott.

    In: Frontiers in Neuroscience, Vol. 13, 1187, 01.11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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