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Peter Kappel Theil

Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows

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Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows. / Hu, Liang; Che, Lianqiang; Wu, Chen; Curtasu, Mihai Victor; Wu, Fali; Fang, Zhengfeng; Lin, Yan; Xu, Shengyu; Feng, Bin; Li, Jian; Zhuo, Yong; Theil, Peter Kappel; Wu, De.

In: Metabolites, Vol. 9, No. 12, 295, 12.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Hu, L, Che, L, Wu, C, Curtasu, MV, Wu, F, Fang, Z, Lin, Y, Xu, S, Feng, B, Li, J, Zhuo, Y, Theil, PK & Wu, D 2019, 'Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows', Metabolites, vol. 9, no. 12, 295. https://doi.org/10.3390/metabo9120295

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Author

Hu, Liang ; Che, Lianqiang ; Wu, Chen ; Curtasu, Mihai Victor ; Wu, Fali ; Fang, Zhengfeng ; Lin, Yan ; Xu, Shengyu ; Feng, Bin ; Li, Jian ; Zhuo, Yong ; Theil, Peter Kappel ; Wu, De. / Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows. In: Metabolites. 2019 ; Vol. 9, No. 12.

Bibtex

@article{169a6b9519ac43a388982b9b42d33bc8,
title = "Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows",
abstract = "Sows suffering excess weight loss during lactation may delay weaning to estrus interval (WEI) and have a detrimental effect on subsequent reproductive performance, however, the underlying mechanism is not completely clear. Therefore, the goal of this study was to investigate physiological profiles manifested in plasma originating from high (HWL) and low lactational weight loss (LWL) sows. The plasma biochemical parameters, hormones, antioxidant parameters, and milk compositions were assessed. Furthermore, plasma metabolites were analyzed using ultrahigh-performance liquid chromatography/time-of-flight mass spectrometry in positive and negative ion modes. Results showed that HWL sows had a lower feed intake and higher lactational weight loss and prolonged WEI, but had similar litter performance and milk composition compared to LWL sows. These changes were associated with lower plasma insulin-like growth factor 1 and higher fibroblast growth factor 21 levels in the HWL sows. Moreover, HWL led to a severe oxidative stress and metabolic damage, as accompanied by excessive protein breakdown and lipids mobilization at weaning. Metabolomic analysis revealed differences in 46 compounds between HWL and LWL sows, and the identified compounds were enriched in metabolic pathways related to amino acids metabolism, fatty acids oxidation metabolism, bile acids biosynthesis, and nucleoside metabolism. These results provide the evidence for physiological mechanism in sows with excessive lactational weight loss that delayed the WEI. Metabolomic data provides essential information and gives rise to potential targets for the development of nutritional intervention strategies.",
keywords = "Lactational weight loss, Metabolites, Oxidative stress, Reproductive performance, Sow",
author = "Liang Hu and Lianqiang Che and Chen Wu and Curtasu, {Mihai Victor} and Fali Wu and Zhengfeng Fang and Yan Lin and Shengyu Xu and Bin Feng and Jian Li and Yong Zhuo and Theil, {Peter Kappel} and De Wu",
year = "2019",
month = "12",
doi = "10.3390/metabo9120295",
language = "English",
volume = "9",
journal = "Metabolites",
issn = "2218-1989",
publisher = "M D P I AG",
number = "12",

}

RIS

TY - JOUR

T1 - Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows

AU - Hu, Liang

AU - Che, Lianqiang

AU - Wu, Chen

AU - Curtasu, Mihai Victor

AU - Wu, Fali

AU - Fang, Zhengfeng

AU - Lin, Yan

AU - Xu, Shengyu

AU - Feng, Bin

AU - Li, Jian

AU - Zhuo, Yong

AU - Theil, Peter Kappel

AU - Wu, De

PY - 2019/12

Y1 - 2019/12

N2 - Sows suffering excess weight loss during lactation may delay weaning to estrus interval (WEI) and have a detrimental effect on subsequent reproductive performance, however, the underlying mechanism is not completely clear. Therefore, the goal of this study was to investigate physiological profiles manifested in plasma originating from high (HWL) and low lactational weight loss (LWL) sows. The plasma biochemical parameters, hormones, antioxidant parameters, and milk compositions were assessed. Furthermore, plasma metabolites were analyzed using ultrahigh-performance liquid chromatography/time-of-flight mass spectrometry in positive and negative ion modes. Results showed that HWL sows had a lower feed intake and higher lactational weight loss and prolonged WEI, but had similar litter performance and milk composition compared to LWL sows. These changes were associated with lower plasma insulin-like growth factor 1 and higher fibroblast growth factor 21 levels in the HWL sows. Moreover, HWL led to a severe oxidative stress and metabolic damage, as accompanied by excessive protein breakdown and lipids mobilization at weaning. Metabolomic analysis revealed differences in 46 compounds between HWL and LWL sows, and the identified compounds were enriched in metabolic pathways related to amino acids metabolism, fatty acids oxidation metabolism, bile acids biosynthesis, and nucleoside metabolism. These results provide the evidence for physiological mechanism in sows with excessive lactational weight loss that delayed the WEI. Metabolomic data provides essential information and gives rise to potential targets for the development of nutritional intervention strategies.

AB - Sows suffering excess weight loss during lactation may delay weaning to estrus interval (WEI) and have a detrimental effect on subsequent reproductive performance, however, the underlying mechanism is not completely clear. Therefore, the goal of this study was to investigate physiological profiles manifested in plasma originating from high (HWL) and low lactational weight loss (LWL) sows. The plasma biochemical parameters, hormones, antioxidant parameters, and milk compositions were assessed. Furthermore, plasma metabolites were analyzed using ultrahigh-performance liquid chromatography/time-of-flight mass spectrometry in positive and negative ion modes. Results showed that HWL sows had a lower feed intake and higher lactational weight loss and prolonged WEI, but had similar litter performance and milk composition compared to LWL sows. These changes were associated with lower plasma insulin-like growth factor 1 and higher fibroblast growth factor 21 levels in the HWL sows. Moreover, HWL led to a severe oxidative stress and metabolic damage, as accompanied by excessive protein breakdown and lipids mobilization at weaning. Metabolomic analysis revealed differences in 46 compounds between HWL and LWL sows, and the identified compounds were enriched in metabolic pathways related to amino acids metabolism, fatty acids oxidation metabolism, bile acids biosynthesis, and nucleoside metabolism. These results provide the evidence for physiological mechanism in sows with excessive lactational weight loss that delayed the WEI. Metabolomic data provides essential information and gives rise to potential targets for the development of nutritional intervention strategies.

KW - Lactational weight loss

KW - Metabolites

KW - Oxidative stress

KW - Reproductive performance

KW - Sow

UR - http://www.scopus.com/inward/record.url?scp=85076292239&partnerID=8YFLogxK

U2 - 10.3390/metabo9120295

DO - 10.3390/metabo9120295

M3 - Journal article

C2 - 31817081

AN - SCOPUS:85076292239

VL - 9

JO - Metabolites

JF - Metabolites

SN - 2218-1989

IS - 12

M1 - 295

ER -