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Peter Funch
Spider genomes provide insight into composition and evolution of venom and silk
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Spider genomes provide insight into composition and evolution of venom and silk. / Sanggaard, Kristian W; Bechsgaard, Jesper S; Fang, Xiaodong; Duan, Jinjie; Dyrlund, Thomas F; Gupta, Vikas; Jiang, Xuanting; Cheng, Ling; Fan, Dingding; Feng, Yue; Han, Lijuan; Huang, Zhiyong; Wu, Zongze; Liao, Li; Settepani, Virginia; Thøgersen, Ida B; Vanthournout, Bram; Wang, Tobias; Zhu, Yabing; Funch, Peter; Enghild, Jan Johannes; Schauser, Leif; Andersen, Stig U; Villesen, Palle; Schierup, Mikkel Heide; Bilde, Trine; Wang, Jun.
In: Nature Communications, Vol. 5, 3765, 2014.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Spider genomes provide insight into composition and evolution of venom and silk
AU - Sanggaard, Kristian W
AU - Bechsgaard, Jesper S
AU - Fang, Xiaodong
AU - Duan, Jinjie
AU - Dyrlund, Thomas F
AU - Gupta, Vikas
AU - Jiang, Xuanting
AU - Cheng, Ling
AU - Fan, Dingding
AU - Feng, Yue
AU - Han, Lijuan
AU - Huang, Zhiyong
AU - Wu, Zongze
AU - Liao, Li
AU - Settepani, Virginia
AU - Thøgersen, Ida B
AU - Vanthournout, Bram
AU - Wang, Tobias
AU - Zhu, Yabing
AU - Funch, Peter
AU - Enghild, Jan Johannes
AU - Schauser, Leif
AU - Andersen, Stig U
AU - Villesen, Palle
AU - Schierup, Mikkel Heide
AU - Bilde, Trine
AU - Wang, Jun
PY - 2014
Y1 - 2014
N2 - Spiders are ecologically important predators with complex venom and extraordinarily tough silk that enables capture of large prey. Here we present the assembled genome of the social velvet spider and a draft assembly of the tarantula genome that represent two major taxonomic groups of spiders. The spider genomes are large with short exons and long introns, reminiscent of mammalian genomes. Phylogenetic analyses place spiders and ticks as sister groups supporting polyphyly of the Acari. Complex sets of venom and silk genes/proteins are identified. We find that venom genes evolved by sequential duplication, and that the toxic effect of venom is most likely activated by proteases present in the venom. The set of silk genes reveals a highly dynamic gene evolution, new types of silk genes and proteins, and a novel use of aciniform silk. These insights create new opportunities for pharmacological applications of venom and biomaterial applications of silk.
AB - Spiders are ecologically important predators with complex venom and extraordinarily tough silk that enables capture of large prey. Here we present the assembled genome of the social velvet spider and a draft assembly of the tarantula genome that represent two major taxonomic groups of spiders. The spider genomes are large with short exons and long introns, reminiscent of mammalian genomes. Phylogenetic analyses place spiders and ticks as sister groups supporting polyphyly of the Acari. Complex sets of venom and silk genes/proteins are identified. We find that venom genes evolved by sequential duplication, and that the toxic effect of venom is most likely activated by proteases present in the venom. The set of silk genes reveals a highly dynamic gene evolution, new types of silk genes and proteins, and a novel use of aciniform silk. These insights create new opportunities for pharmacological applications of venom and biomaterial applications of silk.
KW - Biological sciences
KW - Evolution
KW - Genetics
U2 - 10.1038/ncomms4765
DO - 10.1038/ncomms4765
M3 - Journal article
C2 - 24801114
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 3765
ER -