Per Kallestrup

Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe : Systemic inflammation during co-infection and after treatment for schistosomiasis. / Erikstrup, C.; Kallestrup, Per; Zinyama-Gutsire, R.B.L.; Gomo, E.; Van Dam, G.J.; Deelder, A.M.; Butterworth, A.E.; Pedersen, B.K.; Ostrowski, Sisse Rye; Gerstoft, Jan; Ullum, Henrik.

In: American Journal of Tropical Medicine and Hygiene, Vol. 79, No. 3, 01.09.2008, p. 331-337.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Erikstrup, C, Kallestrup, P, Zinyama-Gutsire, RBL, Gomo, E, Van Dam, GJ, Deelder, AM, Butterworth, AE, Pedersen, BK, Ostrowski, SR, Gerstoft, J & Ullum, H 2008, 'Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis', American Journal of Tropical Medicine and Hygiene, vol. 79, no. 3, pp. 331-337.

APA

Erikstrup, C., Kallestrup, P., Zinyama-Gutsire, R. B. L., Gomo, E., Van Dam, G. J., Deelder, A. M., ... Ullum, H. (2008). Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis. American Journal of Tropical Medicine and Hygiene, 79(3), 331-337.

CBE

Erikstrup C, Kallestrup P, Zinyama-Gutsire RBL, Gomo E, Van Dam GJ, Deelder AM, Butterworth AE, Pedersen BK, Ostrowski SR, Gerstoft J, Ullum H. 2008. Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis. American Journal of Tropical Medicine and Hygiene. 79(3):331-337.

MLA

Vancouver

Erikstrup C, Kallestrup P, Zinyama-Gutsire RBL, Gomo E, Van Dam GJ, Deelder AM et al. Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis. American Journal of Tropical Medicine and Hygiene. 2008 Sep 1;79(3):331-337.

Author

Erikstrup, C. ; Kallestrup, Per ; Zinyama-Gutsire, R.B.L. ; Gomo, E. ; Van Dam, G.J. ; Deelder, A.M. ; Butterworth, A.E. ; Pedersen, B.K. ; Ostrowski, Sisse Rye ; Gerstoft, Jan ; Ullum, Henrik. / Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe : Systemic inflammation during co-infection and after treatment for schistosomiasis. In: American Journal of Tropical Medicine and Hygiene. 2008 ; Vol. 79, No. 3. pp. 331-337.

Bibtex

@article{033ecfa6fb0448bbb260af8fb4607e2a,
title = "Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis",
abstract = "We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-α receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P <0.05) and IL-10 (P <0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.",
author = "C. Erikstrup and Per Kallestrup and R.B.L. Zinyama-Gutsire and E. Gomo and {Van Dam}, G.J. and A.M. Deelder and A.E. Butterworth and B.K. Pedersen and Ostrowski, {Sisse Rye} and Jan Gerstoft and Henrik Ullum",
year = "2008",
month = "9",
day = "1",
language = "English",
volume = "79",
pages = "331--337",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "3",

}

RIS

TY - JOUR

T1 - Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe

T2 - Systemic inflammation during co-infection and after treatment for schistosomiasis

AU - Erikstrup, C.

AU - Kallestrup, Per

AU - Zinyama-Gutsire, R.B.L.

AU - Gomo, E.

AU - Van Dam, G.J.

AU - Deelder, A.M.

AU - Butterworth, A.E.

AU - Pedersen, B.K.

AU - Ostrowski, Sisse Rye

AU - Gerstoft, Jan

AU - Ullum, Henrik

PY - 2008/9/1

Y1 - 2008/9/1

N2 - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-α receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P <0.05) and IL-10 (P <0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.

AB - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-α receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P <0.05) and IL-10 (P <0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.

UR - http://www.scopus.com/inward/record.url?scp=51949112167&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:51949112167

VL - 79

SP - 331

EP - 337

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 3

ER -