Per Kallestrup

Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: Systemic inflammation during co-infection and after treatment for schistosomiasis

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  • C. Erikstrup, Skejby Sygehus, Denmark
  • Per Kallestrup
  • R.B.L. Zinyama-Gutsire, National Institute of Health Research
  • ,
  • E. Gomo, University of Malawi
  • ,
  • G.J. Van Dam, Leiden University Medical Center
  • ,
  • A.M. Deelder, Leiden University Medical Center
  • ,
  • A.E. Butterworth, Biomedical Research and Training Institute
  • ,
  • B.K. Pedersen, Rigshospitalet, Denmark
  • Sisse Rye Ostrowski, Institut for Klinisk Medicin, Denmark
  • Jan Gerstoft, Institut for Klinisk Medicin, Denmark
  • Henrik Ullum, Institut for Klinisk Medicin, Denmark
We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-α receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P <0.05) and IL-10 (P <0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.
Original languageEnglish
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume79
Issue3
Pages (from-to)331-337
Number of pages7
ISSN0002-9637
Publication statusPublished - 1 Sep 2008
Externally publishedYes

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