Per Kallestrup

Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Per Kallestrup
  • Rutendo Zinyama, Zimbabwe
  • Exnevia Gomo, Zimbabwe
  • Anthony E Butterworth, Zimbabwe
  • Boniface Mudenge, Zimbabwe
  • Govert J van Dam, Netherlands
  • Jan Gerstoft, Center for inflammation og Metabolisme, Rigshospitalet, Denmark
  • Christian Erikstrup
  • Henrik Ullum, Center for inflammation og Metabolisme, Rigshospitalet, Klinisk Immunologi, Rigshospitalet, Denmark
To determine whether treatment of schistosomiasis has an effect on the course of human immunodeficiency virus type 1 (HIV-1) infection, individuals with schistosomiasis and with or without HIV-1 infection were randomized to receive praziquantel treatment at inclusion or after a delay of 3 months; 287 participants were included in the study, and 227 (79%) were followed up. Among the 130 participants who were coinfected, those who received early treatment (n=64) had a significantly lower increase in plasma HIV-1 RNA load than did those who received delayed treatment (n=66) (P
Original languageEnglish
JournalJournal of Infectious Diseases
Volume192
Issue11
Pages (from-to)1956-61
Number of pages6
ISSN0022-1899
DOIs
Publication statusPublished - 2005
Externally publishedYes

    Research areas

  • Adult, Anthelmintics, CD4 Lymphocyte Count, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Male, Praziquantel, RNA, Viral, Rural Population, Schistosomiasis, Treatment Outcome, Viral Load, Zimbabwe

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