Per Kallestrup

Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium

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  • Chalotte Willemann Stecher, Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
  • ,
  • Henry Madsen, Section for Parasitology and Aquatic Diseases, SUND, University of Copenhagen, Denmark.
  • ,
  • Shona Wilson, Department of Pathology, University of Cambridge, United Kingdom.
  • ,
  • Moussa Sacko, Laboratory of Parasitology, Institut National de Recerche en Sante Publique, Bamako, Mali.
  • ,
  • Christian Wejse
  • Adama D Keita, University of Sciences, Techniques and Technology, Bamako, Mali.
  • ,
  • Aly Landouré, Laboratory of Parasitology, Institut National de Recerche en Sante Publique, Bamako, Mali.
  • ,
  • Mamadou S Traoré, Laboratory of Parasitology, Institut National de Recerche en Sante Publique, Bamako, Mali.
  • ,
  • Per Kallestrup
  • Eskild Petersen
  • Birgitte Vennervald, Section for Parasitology and Aquatic Diseases, SUND, University of Copenhagen, Denmark.

Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17-1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.

Original languageEnglish
JournalHeliyon
Volume3
Issue11
Pages (from-to)e00440
ISSN2405-8440
DOIs
Publication statusPublished - Nov 2017

    Research areas

  • Journal Article

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