Per Kallestrup

HLA-G 3' Untranslated Region 14-Base Pair Deletion: Association With Poor Survival in an HIV-1-Infected Zimbabwean Population

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Margit Hørup Larsen
  • ,
  • Rutendo Zinyama
  • ,
  • Per Kallestrup
  • Jan Gerstoft, Diagnostiske Fag, Denmark
  • Exnevia Gomo
  • ,
  • Lise Wegner Thørner
  • ,
  • Trine Baldorf Berg
  • ,
  • Christian Erikstrup
  • Henrik Ullum, Institut for Klinisk Medicin, Denmark
We aimed to evaluate whether the HLA-G 14-base pair (bp) polymorphism (rs16375) has an impact on human immunodeficiency virus HIV progression and survival in an antiretroviral therapy-naive Zimbabwean cohort (n = 312). Rs16375 was genotyped using a competitive allele-specific polymerase chain reaction system; CD4 cell counts and HIV RNA were measured with flow cytometry and commercially available polymerase chain reaction; survival was followed up for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P = .004), lower CD4 cell count (P = .01), and increased mortality (hazard ratio, 1.9; 95% confidence interval, 1.033-3.522; P = .04) compared with HLA-G +14-bp carriers.
Original languageEnglish
JournalJournal of Infectious Diseases
Volume207
Issue6
Pages (from-to)903-6
ISSN0022-1899
DOIs
Publication statusPublished - 2013

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