Personal profile
Research
My research is focused on understanding virus-host interaction and how antiviral immunity can be improved through medical interventions to achieve functional cures for HIV and chronic hepatitis B (HBV). My research team has conducted a number of phase 1 and 2 clinical trials, primarily in HIV but also in Covid-19 and chronic HBV infection. The potential impact of treatment with antiviral monoclonal antibodies on long term humoral and cellular immunity is a particular point of interest.
Job responsibilities
HIV; Hepatitis B + D; Phase 1/2 clinical trials; Immunomodulation; Broadly neutralizing antibodies; T cell immunity; Antibody mediated immunity
Areas of expertise
- HIV
- Infectious Diseases
- Clinical trials
- Monoclonal antibodies
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Collaborations and top research areas from the last five years
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CD8+ T cell stemness precedes post-intervention control of HIV viraemia
Kiani, Z., Urbach, J. M., Wisner, H., Olatotse, M. J., Chang, D. Y., Acklin, J. A., Piechocka-Trocha, A., Bonheur, N., Khatri, A., Lichterfeld, M., Gunst, J. D., Søgaard, O. S., Caskey, M., Nussenzweig, M. C., Walker, B. D. & Collins, D. R., 5 Feb 2026, In: Nature. 650, 8100, p. 196-204 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Immunogenicity of SARS-CoV-2 primary vaccination and boosters in patients with immune-mediated inflammatory diseases: Impact of immunosuppressive therapy
Larsen, F. D., Juhl, A. K., Dietz, L. L., Nielsen, H., Stærke, N. B., Johansen, I. S., Wiese, L., Benfield, T., Bodilsen, J., Klastrup, V., Lindvig, S. O., Rasmussen, L. D., Knudsen, L. S., Tolstrup, M., Østergaard, L. J., Lundgren, J., Søgaard, O. S., Larsen, C. S. & ENFORCE Study Group, 15 Feb 2026, In: Vaccine. 73, 128155.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Isohemagglutinins exhibit synergistic polyreactivity toward Streptococcus pneumoniae surface antigens: implications for broad-spectrum reactivity of human antibodies
Bernth Jensen, J. M., Søgaard, O. S., Petersen, M. S., Hoffmann, S., Møller, B. K., Hansen, A. G., Sørensen, U. B. S. & Thiel, S., 9 Jan 2026, In: Medical Microbiology and Immunology. 215, 1, 5.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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A Participant-Derived Xenograft Mouse Model to Decode Autologous Mechanisms of HIV Control and Evaluate Immunotherapies
Iversen, E. F., Miller, I. G., Søgaard, O., Danesh, A. & Jones, R. B., 5 Apr 2025, In: Bio-protocol. 15, 7, 16 p., e5254.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
Evaluation and real-world experience of a neutralization susceptibility screening assay for broadly neutralizing anti-HIV-1 antibodies
Pahus, M. H., Zheng, Y., Olefsky, M., Gunst, J. D., Tebas, P., Taiwo, B., Søgaard, O. S., Peluso, M. J., Lie, Y., Reeves, J. D., Petropoulos, C. J., Caskey, M. & Bar, K. J., 15 Feb 2025, In: The Journal of Infectious Diseases. 231, 2, p. 424-434 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus)
Activities
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Board member and treasurer
Søgaard, O. S. (Lecturer)
1 Sept 2022 → 1 Sept 2028Activity: Presentations, memberships, employment, ownership and other activities › Other
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NSCMID
Søgaard, O. S. (Member)
2021Activity: Presentations, memberships, employment, ownership and other activities › Member of board or management of company or organisation
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Consultation on drug development and treatment strategies
Søgaard, O. S. (Consultant)
1 Jan 2015 → 1 Jan 2025Activity: Consultancy types › Consultancy
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26th Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy
Søgaard, O. S. (Participant)
3 Sept 2009 → 6 Sept 2009Activity: Participating in or organising an event types › Participation in or organisation af a conference
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16th Conference on retrovirus and Opportunistic Infections
Søgaard, O. S. (Participant)
8 Feb 2009 → 11 Feb 2009Activity: Participating in or organising an event types › Participation in or organisation af a conference
Prizes
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Hospitalization for pneumonia among individuals with and without HIV in Denmark 1995 - 2004
Søgaard, O. S. (Recipient), 3 Feb 2008
Prize: Prizes, scholarships, distinctions