Ole Bækgaard Nielsen

Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition

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Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. / Fabiansen, Christian; Lykke, Mikkel; Hother, Anne-Louise; Koch, Jørgen; Nielsen, Ole Bækgaard; Hunter, Ingrid; Goetze, Jens P; Friis, Henrik; Thymann, Thomas.

In: PLOS ONE, Vol. 10, No. 10, 2015, p. e0140472.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Fabiansen, C, Lykke, M, Hother, A-L, Koch, J, Nielsen, OB, Hunter, I, Goetze, JP, Friis, H & Thymann, T 2015, 'Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition', PLOS ONE, vol. 10, no. 10, pp. e0140472. https://doi.org/10.1371/journal.pone.0140472

APA

Fabiansen, C., Lykke, M., Hother, A-L., Koch, J., Nielsen, O. B., Hunter, I., Goetze, J. P., Friis, H., & Thymann, T. (2015). Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. PLOS ONE, 10(10), e0140472. https://doi.org/10.1371/journal.pone.0140472

CBE

Fabiansen C, Lykke M, Hother A-L, Koch J, Nielsen OB, Hunter I, Goetze JP, Friis H, Thymann T. 2015. Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. PLOS ONE. 10(10):e0140472. https://doi.org/10.1371/journal.pone.0140472

MLA

Vancouver

Fabiansen C, Lykke M, Hother A-L, Koch J, Nielsen OB, Hunter I et al. Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. PLOS ONE. 2015;10(10):e0140472. https://doi.org/10.1371/journal.pone.0140472

Author

Fabiansen, Christian ; Lykke, Mikkel ; Hother, Anne-Louise ; Koch, Jørgen ; Nielsen, Ole Bækgaard ; Hunter, Ingrid ; Goetze, Jens P ; Friis, Henrik ; Thymann, Thomas. / Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. In: PLOS ONE. 2015 ; Vol. 10, No. 10. pp. e0140472.

Bibtex

@article{618045801b33476b80117975012952d4,
title = "Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition",
abstract = "BACKGROUND: Half a million children die annually of severe acute malnutrition and cardiac dysfunction may contribute to the mortality. However, cardiac function remains poorly examined in cases of severe acute malnutrition.OBJECTIVE: To determine malnutrition-induced echocardiographic disturbances and longitudinal changes in plasma pro-atrial natriuretic peptide and cardiac troponin-T in a pediatric porcine model.METHODS AND RESULTS: Five-week old piglets (Duroc-x-Danish Landrace-x-Yorkshire) were fed a nutritionally inadequate maize-flour diet to induce malnutrition (MAIZE, n = 12) or a reference diet (AGE-REF, n = 12) for 7 weeks. Outcomes were compared to a weight-matched reference group (WEIGHT-REF, n = 8). Pro-atrial natriuretic peptide and cardiac troponin-T were measured weekly. Plasma pro-atrial natriuretic peptide decreased in both MAIZE and AGE-REF during the first 3 weeks but increased markedly in MAIZE relative to AGE-REF during week 5-7 (p ≤ 0.001). There was overall no difference in plasma cardiac troponin-T between groups. However, further analysis revealed that release of cardiac troponin-T in plasma was more frequent in AGE-REF compared with MAIZE (OR: 4.8; 95%CI: 1.2-19.7; p = 0.03). However, when release occurred, cardiac troponin-T concentration was 6.9-fold higher (95%CI: 3.0-15.9; p < 0.001) in MAIZE compared to AGE-REF. At week 7, the mean body weight in MAIZE was lower than AGE-REF (8.3 vs 32.4 kg, p < 0.001), whereas heart-weight relative to body-weight was similar across the three groups. The myocardial performance index was 86% higher in MAIZE vs AGE-REF (p < 0.001) and 27% higher in MAIZE vs WEIGHT-REF (p = 0.025).CONCLUSIONS: Malnutrition associates with cardiac dysfunction in a pediatric porcine model by increased myocardial performance index and pro-atrial natriuretic peptide and it associates with cardiac injury by elevated cardiac troponin-T. Clinical studies are needed to see if the same applies for children suffering from malnutrition.",
author = "Christian Fabiansen and Mikkel Lykke and Anne-Louise Hother and J{\o}rgen Koch and Nielsen, {Ole B{\ae}kgaard} and Ingrid Hunter and Goetze, {Jens P} and Henrik Friis and Thomas Thymann",
year = "2015",
doi = "10.1371/journal.pone.0140472",
language = "English",
volume = "10",
pages = "e0140472",
journal = "P L o S One",
issn = "1932-6203",
publisher = "public library of science",
number = "10",

}

RIS

TY - JOUR

T1 - Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition

AU - Fabiansen, Christian

AU - Lykke, Mikkel

AU - Hother, Anne-Louise

AU - Koch, Jørgen

AU - Nielsen, Ole Bækgaard

AU - Hunter, Ingrid

AU - Goetze, Jens P

AU - Friis, Henrik

AU - Thymann, Thomas

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Half a million children die annually of severe acute malnutrition and cardiac dysfunction may contribute to the mortality. However, cardiac function remains poorly examined in cases of severe acute malnutrition.OBJECTIVE: To determine malnutrition-induced echocardiographic disturbances and longitudinal changes in plasma pro-atrial natriuretic peptide and cardiac troponin-T in a pediatric porcine model.METHODS AND RESULTS: Five-week old piglets (Duroc-x-Danish Landrace-x-Yorkshire) were fed a nutritionally inadequate maize-flour diet to induce malnutrition (MAIZE, n = 12) or a reference diet (AGE-REF, n = 12) for 7 weeks. Outcomes were compared to a weight-matched reference group (WEIGHT-REF, n = 8). Pro-atrial natriuretic peptide and cardiac troponin-T were measured weekly. Plasma pro-atrial natriuretic peptide decreased in both MAIZE and AGE-REF during the first 3 weeks but increased markedly in MAIZE relative to AGE-REF during week 5-7 (p ≤ 0.001). There was overall no difference in plasma cardiac troponin-T between groups. However, further analysis revealed that release of cardiac troponin-T in plasma was more frequent in AGE-REF compared with MAIZE (OR: 4.8; 95%CI: 1.2-19.7; p = 0.03). However, when release occurred, cardiac troponin-T concentration was 6.9-fold higher (95%CI: 3.0-15.9; p < 0.001) in MAIZE compared to AGE-REF. At week 7, the mean body weight in MAIZE was lower than AGE-REF (8.3 vs 32.4 kg, p < 0.001), whereas heart-weight relative to body-weight was similar across the three groups. The myocardial performance index was 86% higher in MAIZE vs AGE-REF (p < 0.001) and 27% higher in MAIZE vs WEIGHT-REF (p = 0.025).CONCLUSIONS: Malnutrition associates with cardiac dysfunction in a pediatric porcine model by increased myocardial performance index and pro-atrial natriuretic peptide and it associates with cardiac injury by elevated cardiac troponin-T. Clinical studies are needed to see if the same applies for children suffering from malnutrition.

AB - BACKGROUND: Half a million children die annually of severe acute malnutrition and cardiac dysfunction may contribute to the mortality. However, cardiac function remains poorly examined in cases of severe acute malnutrition.OBJECTIVE: To determine malnutrition-induced echocardiographic disturbances and longitudinal changes in plasma pro-atrial natriuretic peptide and cardiac troponin-T in a pediatric porcine model.METHODS AND RESULTS: Five-week old piglets (Duroc-x-Danish Landrace-x-Yorkshire) were fed a nutritionally inadequate maize-flour diet to induce malnutrition (MAIZE, n = 12) or a reference diet (AGE-REF, n = 12) for 7 weeks. Outcomes were compared to a weight-matched reference group (WEIGHT-REF, n = 8). Pro-atrial natriuretic peptide and cardiac troponin-T were measured weekly. Plasma pro-atrial natriuretic peptide decreased in both MAIZE and AGE-REF during the first 3 weeks but increased markedly in MAIZE relative to AGE-REF during week 5-7 (p ≤ 0.001). There was overall no difference in plasma cardiac troponin-T between groups. However, further analysis revealed that release of cardiac troponin-T in plasma was more frequent in AGE-REF compared with MAIZE (OR: 4.8; 95%CI: 1.2-19.7; p = 0.03). However, when release occurred, cardiac troponin-T concentration was 6.9-fold higher (95%CI: 3.0-15.9; p < 0.001) in MAIZE compared to AGE-REF. At week 7, the mean body weight in MAIZE was lower than AGE-REF (8.3 vs 32.4 kg, p < 0.001), whereas heart-weight relative to body-weight was similar across the three groups. The myocardial performance index was 86% higher in MAIZE vs AGE-REF (p < 0.001) and 27% higher in MAIZE vs WEIGHT-REF (p = 0.025).CONCLUSIONS: Malnutrition associates with cardiac dysfunction in a pediatric porcine model by increased myocardial performance index and pro-atrial natriuretic peptide and it associates with cardiac injury by elevated cardiac troponin-T. Clinical studies are needed to see if the same applies for children suffering from malnutrition.

U2 - 10.1371/journal.pone.0140472

DO - 10.1371/journal.pone.0140472

M3 - Journal article

C2 - 26473958

VL - 10

SP - e0140472

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 10

ER -