Olav Michael Andersen

Associate Professor

Profile photoOlav Michael Andersen
Associate professor
Department of Biomedicine - Medical Biochemistry
Ole Worms Allé 3, 1171, 220
8000, Aarhus C
Denmark
E-mail: o.andersen@biokemi.au.dk
Phone: +45 87167786
Mobile: +45 20370740

Education

2002 Ph.D in Molecular biology, Aarhus University Denmark. Title og thesis: "Preferential ligand binding to lipoprotein receptors"
1997 MSc in Chemistry-Biotechnology, Aarhus University, Denmark

Scientific career

2013-Editorial Board Member “Receptors & Clinical Investigation”
2011-Associate professor, department of Biomedicine, Health, Aarhus University, Denmark
2008-2011Assistant professor, department of Medical Biochemistry, Faculty of Health Sciences, Aarhus University
2007-2008Postdoctoral fellow, department of Medical Biochemistry, Faculty of Health Sciences, Aarhus University
2001-2007Postdoctoral fellow, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
1997-2001PhD student, department of Molecular biology, faculty of Sciences, Aarhus University
2000Visiting Scientist, Center for Advanced Research in Biotechnology, National Institute of Standards and Technology, Maryland, USA
1998EMBO summerschool, "Ligand-Receptor interactions, Analysis by Integrated Advarnced Methods" , Bologna, Italy
1998FEBS Summer School, "New strategies and Methods in Protein research", Urbino, Italy

Awards

BIAcore Science Award 2004, Germany

Selected Lectures

2012Invited speaker at The 32nd Annual Meeting of the Australian Neuroscience Society, Gold Coast, Australia: “Identification of amino acids in sorLA that influence APP processing and protects against Alzheimer’s disease”
2010Speaker at The 11th International Conference on Alzheimer’s disease and Related Disorders, Honolulu, USA: “The role of retromer in sorLA-dependent processing of APP”
2009Invited speaker at The 29th Australian Neuroscience Society Meeting, Canberra, Australia: “The Role of sorLA/LR11 in Amyloid Precursor Protein Metabolism”. Presenting as a/ ‘highlights of the program’ and subsequent interviewed by the Australian media)
2007Invited speaker at the Biocenter seminars at Copenhagen University, Denmark: “The role of sorLA/LR11 in APP transport and Alzheimer's disease”.
2006Presentation at the Wollenberger Seminar, MDC-Berlin, Germany: ”A desicive role for sorLA in amyloid protein precursor metabolism”
2005Invited presentation at the Institute of Molecular Biology, University of Copenhagen, Denmark: “SorLA, a neuronal sorting receptor for amyloid protein precursor”
2005Speaker at The 7th International ADPD meeting in Sorrento, Italy: “SorLA, a neuronal sorting receptor for amyloid protein precursor”
2004Invited talk, hosted by Biacore, Göttingen, Germany: “Differential binding of ligands to the apolipoprotein E receptor 2”
2004The Butterfly Seminar, MDC-Berlin, Germany: “SorLA, a neuronal sorting receptor for APP”.
2003The Wollenberger Seminar, MDC-Berlin, Germany. “A novel lipoprotein receptor with a proposed role in APP metabolism”.
2003Invited talk, hosted by Eli Lilly, Indianapolis, USA: “SorLA - A brain receptor with a proposed role in APP metabolism”.

Bibliometric data

32 peer reviewed publications (13 of those as first author and 7 as last author) 1 book chapter,1 patent application
H-index 15 (Scopus; total number of citations 1000)

Book chapters

2008Lipoprotein receptors in Alzheimer’s disease, in “Research Progress in Alzheimer’s Disease and Dementia; Author: Olav M. Andersen and Thomas E. Willnow Publisher: Nova Publishers

Patents

2008Modulation of activity of neurotrophins Patent #200601692. Aplicants: Olav M. Andersen and Anders Nykjær

Publications

The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

Mishra, S., Knupp, A., Szabo, M. P., Williams, C. A., Kinoshita, C., Hailey, D. W., Wang, Y., Andersen, O. M. & Young, J. E., Feb 2022, In: Cellular and Molecular Life Sciences. 79, 3, 22 p., 162.

Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling

Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E., Patel, V., Kannan, S., Kim, Y. H., Chang, K. T., Alzheimer's Disease Neuroimaging Initiative, Hussaini, S. A., Moreno, H., Di Paolo, G., Andersen, O. M. & Small, S. A., Dec 2021, In: Cell Reports. 37, 13, 110182.

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M., Mar 2021, In: Acta Neuropathologica Communications. 9, 43.

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

Al-Akhrass, H., Conway, J. R. W., Poulsen, A. S. A., Paatero, I., Kaivola, J., Padzik, A., Andersen, O. M. & Ivaska, J., 18 Feb 2021, In: Oncogene. 40, 7, p. 1300-1317 18 p.

SORLA Expression in Synaptic Plexiform Layers of Mouse Retina

Monti, G., Jensen, M. L., Mehmedbasic, A., Jørgensen, M. M., Holm, I. E., Barkholt, P., Zole, E., Vægter, C. B., Vorum, H., Nyengaard, J. R. & Andersen, O. M., 2020, In: Molecular Neurobiology. 57, 7, p. 3106-3117 12 p.

Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A., 19 Jun 2019, In: Science Advances. 5, 6, 13 p., eaav9946.

SORLA regulates endosomal trafficking and oncogenic fitness of HER2

Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N. Z., Paatero, I., Närvä, E., Al-Akhrass, H., Lilja, J., Georgiadou, M., Andersen, O. M., Padzik, A., Sihto, H., Joensuu, H., Blomqvist, M., Saarinen, I., Boström, P. J., Taimen, P. & Ivaska, J., May 2019, In: Nature Communications. 10, 1, p. 1-16 16 p., 2340.

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression

Gonçalves, N. P., Mohseni, S., El Soury, M., Ulrichsen, M., Richner, M., Xiao, J., Wood, R. J., Andersen, O. M., Coulson, E. J., Raimondo, S., Murray, S. S. & Vægter, C. B., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 235.

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor

Blechingberg, J., Poulsen, A. S. A., Kjølby, M., Monti, G., Allen, M., Ivarsen, A. K., Lincoln, S. J., Thotakura, G., Vægter, C. B., Ertekin-Taner, N., Nykjær, A. & Andersen, O. M., Nov 2018, In: Neurobiology of Aging. 71, p. 266.e11-266.e24 14 p.

Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface

Mygind, K. J., Störiko, T., Freiberg, M. L., Samsøe-Petersen, J., Schwarz, J., Andersen, O. M. & Kveiborg, M., 25 May 2018, In: Journal of Biological Chemistry. 293, 21, p. 8077-8088 12 p.

20 Years Anniversary for SORLA/SORL1 (1996-2016)

Monti, G. & Andersen, O. M., Dec 2017, In: Receptors and Clinical Investigation. 4, 4, p. 2-10 e1611.

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease

Andersen, O. M., Rudolph, I-M. & Willnow, T. E., 16 Sep 2016, In: Acta Neuropathologica. 132, 5, p. 653–665 9 p.

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

Glerup, S., Bolcho, U., Bøggild, S., Vaegter, C. B., Smith, A. H., Nieto-Gonzalez, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., Kjolby, M., Login, H., Holm, M. M., Andersen, O. M., Nyengaard, J. R., Willnow, T. E., Jensen, K., Nykjaer, A. & Jensen, S. M., 2016, In: Molecular Psychiatry.

The A-B-C for SORting APP

Coulson, E. J. & Andersen, O. M., Oct 2015, In: Journal of Neurochemistry. 135, 1, p. 1-3 3 p.

Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA

Dienemann, C., Coburger, I., Mehmedbasic, A., Andersen, O. M. & Than, M. E., 10 Apr 2015, In: Biochemistry.

SorLA CR-Domains Protect the Amyloid Precursor Protein against Processing

Mehmedbasic, A., Christensen, S. K., Nilsson, J., Rüetschi, U., Gustafsen, C., Poulsen, A. S. A., Rasmussen, R. W., Fjorback, A. N., Larson, G. & Andersen, O. M., 18 Dec 2014, In: Journal of Biological Chemistry.

New Horizons for Lipoprotein ReceptorsCommunication by β-propellers

Andersen, O. M., Dagil, R. & Kragelund, B. B., Oct 2013, In: Journal of Lipid Research. 54(10), p. 2763- 2774 11 p.

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease

Willnow, T. E. & Andersen, O. M., 1 Jul 2013, In: Journal of Cell Science. 126, Pt 13, p. 2751-60 10 p.

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjær, A., Madsen, P. & Petersen, C. M., 2013, In: Journal of Neuroscience. 33, 1, p. 64-71 8 p.

SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein

Fjorback, A. W. & Andersen, O. M., 1 Nov 2012, In: Communicative & Integrative Biology. 5, 6, p. 616-9 4 p.

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

Fjorback, A. W., Seaman, M., Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R., E Willnow, T., Christensen, E. I., B Mobley, W., Nykjær, A. & Andersen, O. M., 2012, In: Journal of Neuroscience. 32, 4, p. 1467-1480 14 p.

APP involvement in retinogenesis of mice

Dinet, V., An, N., Ciccotosto, G. D., Bruban, J., Maoui, A., Bellingham, S. A., Hill, A. F., Andersen, O. M., Nykjaer, A., Jonet, L., Cappai, R. & Mascarelli, F., 1 Mar 2011, In: Acta Neuropathologica. 121, 3, p. 351-63 13 p.

The structure of MESD45-184 brings light into the mechanism of LDLR family folding

Köhler, C., Lighthouse, J. K., Werther, T., Andersen, O. M., Diehl, A., Schmieder, P., Du, J., Holdener, B. C. & Oschkinat, H., 2011, In: Structure. 19, 3, p. 337-48 12 p.

Identification of a linear epitope in sortilin that partakes in pro-neurotropin binding

Andersen, O. S., Boisguerin, P., Glerup, S., Skeldal, S., Volkmer, R., Wilnow, T. E., Nykjær, A. & Andersen, O. M., 2010, In: Journal of Biological Chemistry. p. 12210-12222 22 p.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Kjølby, M. F., Andersen, O. M., Breiderhoff, T., Fjorback, A. N., Pedersen, K-M., Madsen, P. S., Jansen, P., Heeren, J., Willnow, T. & Nykjær, A., 2010, In: Cell Metabolism. 12, 3, p. 213-223 11 p.

Interaction of the Apolipoprotein E Receptors low-density lipoprotein receptor related protein and sorLA/LR11

Spoelgen, R., Adams, K. W., Koker, M., Thomas, A. V., Andersen, O. M., Hallet, P. J., Bercury, K. K., Joyner, D. F., Deng, M., Stoothoff, W. H., Strickland, D. K., Willnow, T. E. & Hyman, B. T., 2009, In: Journal of Neuroscience. 158, p. 1460-1468 8 p.

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease

Dodson, S. E., Andersen, O. M., Karmali, V., Fritz, J. J., Cheng, D., Peng, J., Levey, A. I., Wilnow, T. E. & Lah, J. J., 2008, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 28, p. 12877-12886 9 p.

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependant stimulation of ERK signalling and adult neurogenesis

Rohe, M., Carlo, A. S., Breyhan, H., Sporbert, A., Millitz, D., Schmidt, V., Wozny, C., Harmeier, A., Erdmann, B., Bales, K. R., Wolf, S., Kempermann, G., Paul, S. M., Schmitz, D., Bayer, T. A., Wilnow, T. E. & Andersen, O. M., 2008, In: Journal of Biological Chemistry. J. Biol Chem, 283, p. 14826-14834 8 p.

Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.

Sarafanov, A. G., Makagonenko, E. M., Andersen, O., Mikhailenko, I. A., Ananyeva, N. M., Khrenov, A. V., Shima, M., Strickland, D. K. & Saenko, E. L., 2007, In: Thromb. Haemost.. 98, p. 1170-1181 12 p.

SorLA/LR11 regulates processing of the amyloid precursor protein via interactions with adaptors GGA and PACS-1.

Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O. & Wilnow, T. E., 2007, In: Journal of Biological Chemistry. 282, p. 32956-32964 9 p.

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.

Köhler, C., Andersen, O., Diehl, A., Krause, G., Schmieder, P. & Oschkinat, H., 2007, In: J. Struct. Funct. Genom.. 7, p. 131-138 8 p.

Binding site structure of one LRP/RAP complex - Implications for common ligand-receptor binding motif.

Jensen, G. A., Andersen, O., Bonvin, A. M., Bjerrum-Bohr, I., Etzerodt, M., Thøgersen, H. C., O'Shea, B., Poulsen, F. M. & Kragelund, B. B., 2006, In: J. Mol. Biol.. 362, p. 700-716 17 p.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein and β-secretase, BACE.

Spoelgen, R., Peltan, I. D., Thomas, A. V., Koker, M., von Armin, C. A. F., Deng, A., Andersen, O., Willnow, T. E. & Hyman, B. T., 2006, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 45, 8, p. 2618-2628 11 p.

Molecular Dissection of the Interaction Between Amyloid Precursor Protein and Its Neuronal Trafficking Receptor SorLA/LR11.

Andersen, O., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W. J., Parker, M. W., Masters, C. L., Hyman, B. T., Cappai, R. & Wilnow, T. E., 2006, In: Biochemistry. 45, 8, p. 2618-2628 11 p.

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease.

Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., Chen, F., Shíbata, N., Lunetta, K. L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L. A., Kuenco, K. T., Green, R. C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R., Inzelberg, R., Hampe, W., Bujo, H., Song, Y., Andersen, O., Wilnow, T. E., Graff-Redford, N., Petersen, R. C., Dickson, D., Der, S. D., Fraser, P. E., Ulms, G., Younkin, S., Mayeux, R., Farrer, L. A. & St George-Hyslop, P., 2006, In: Nat. Genet.. 39, p. 168-177 10 p.

LRP2/Megalin is required for patterning of the ventral telencephalon.

Spoelgen, R., Hammes, A., Anzenberger, U., Sechner, D., Andersen, O., Jerchow, B. & Wilnov, T. E., 2005, In: Developement. 132, p. 405-414 9 p.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Andersen, O., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., Arnim, C. A. V., Breiderhoff, T., Jansen, P., Wu, X., Bales, K. R., Cappai, R., Masters, C. L., Gliemann, J., Mufson, E. J., Hyman, B. T., Paul, S. M., Nykjær, A. & Wilnow, T. E., 2005, In: Proceedings of the National Academy of Sciences of the United States of America. p. 13461-13466 5 p.

Ca2+ binding to complement-type repeat domains 5 and 6 from the low density lipoprotein receptor-related protein.

Andersen, O., Vorum, H., Honoré, B. & Thøgersen, H. C., 2003, In: B M C Biochemistry. 4, 1, p. 7-7 1 p.

Differential binding of ligands to the Apolipoprotein E Receptor 2.

Andersen, O., Benhayon, D., Curran, T. & Willnov, T. E., 2003, In: Biochemistry. 42, p. 9355-9364 9 p.

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development.

Andersen, O., Yeung, C. H., Vorum, H., Wellner, M., Andreassen, T. K., Erdmann, B., Mueller, E. C., Herz, J., Otto, A., Cooper, T. G. & Willnov, T. E., 2003, In: Journal of Biological Chemistry. 278, p. 23989-23995 7 p.

Analysis of a two-domain binding site for the urokinase-type plasminogen activator - plasminogen activator inhibitor-1 complex in low density lipoprotein receptor-related protein,

Andersen, O., Petersen, H. H., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Andreasen, P. & Thøgersen, H. C., 2001, In: Biochem. J.. 357, p. 289-296 8 p.

Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP.

Andersen, O., Schwarz, F. P., Eisenstein, E., Jacobsen, C., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C., 2001, In: Biochemistry. 40, p. 15408-15417 10 p.

Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP)

Christensen, L. L., Christensen, P. A., Sørensen, E. S., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Thøgersen, H. & Andersen, O., 2000, In: Journal of Biological Chemistry. 275, 28, p. 21017-21024 8 p.

Specific Binding of a-Macroglobulin to Complement-type Repeat CR4 of the Low Density Lipoprotein Receptor-related Protein.

Andersen, O., Christensen, P. A., Christensen, L. L., Jacobsen, C., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C., 2000, In: Biochemistry. 39, 35, p. 10627-10633 7 p.
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