Research output per year
Research output per year
- 1 - 50 out of 86 results
Search results
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2024
A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting
Fazeli, E., Child, D. D., Bucks, S. A., Stovarsky, M., Edwards, G., Rose, S. E., Yu, C. E., Latimer, C., Kitago, Y., Bird, T., Jayadev, S., Andersen, O. M. & Young, J. E., 20 Jan 2024, In: Acta Neuropathologica. 147, 1, 20.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access4 Citations (Scopus) -
Functional characterization of SORL1 variants in cell-based assays to investigate variant pathogenicity
Fazeli, E., Fazeli, E., Fojtík, P., Holstege, H. & Andersen, O. M., Apr 2024, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 379, 1899, 20220377.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Known disease-causing variants in homologous proteins help predict pathogenicity of SORL1 variants in Alzheimer’s disease
Andersen, O. M., Monti, G., Jensen, A. M. G., de Waal, M. W. J., Hulsman, M., Olsen, J. G. & Holstege, H., Dec 2024, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 20, S1, e084835.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review
Open Access -
Mice and minipigs with compromised expression of the Alzheimer's disease gene SORL1 show cerebral metabolic disturbances on hyperpolarized [1-13C]pyruvate and sodium MRI
Bøgh, N., Sørensen, C. B., Alstrup, A. K. O., Søvsø Szocska Hansen, E., Andersen, O. M. & Laustsen, C., Mar 2024, In: Brain Communications. 6, 2, 10 p., fcae114.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
SorLA restricts TNFα release from microglia to shape a glioma-supportive brain microenvironment
Kaminska, P., Ovesen, P. L., Jakiel, M., Obrebski, T., Schmidt, V., Draminski, M., Bilska, A. G., Bieniek, M., Anink, J., Paterczyk, B., Jensen, A. M. G., Piatek, S., Andersen, O. M., Aronica, E., Willnow, T. E., Kaminska, B., Dabrowski, M. J. & Malik, A. R., May 2024, In: EMBO Reports. 25, 5, p. 2278-2305 28 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
3 Citations (Scopus) -
The effect of specific SORL1 variants on Alzheimer’s Disease risk supports the existence of highly penetrant SORL1 variants
ADES‐consortium, ADSP consortium, StEP‐AD consortium, Knight‐ADRC, UCSF/NYGC/UAB, Dec 2024, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 20, e084836.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review
Open Access -
The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer’s disease
Jensen, A. M. G., Raska, J., Fojtik, P., Monti, G., Lunding, M., Bartova, S., Pospisilova, V., van der Lee, S. J., Van Dongen, J., Bossaerts, L., Van Broeckhoven, C., Dols-Icardo, O., Lléo, A., Bellini, S., Ghidoni, R., Hulsman, M., Petsko, G. A., Sleegers, K., Bohaciakova, D. & Holstege, H. & 1 others, , Sept 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 37, e2408262121.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access3 Citations (Scopus) -
2023
Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer
Jensen, A. M. G., Kitago, Y., Fazeli, E., Vægter, C. B., Small, S. A., Petsko, G. A. & Andersen, O. M., Jan 2023, In: Proceedings of the National Academy of Sciences (PNAS). 120, 4, 11 p., e2212180120.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)4 Downloads (Pure) -
Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA
Monti, G., Vincke, C., Lunding, M., Jensen, A. M. G., Madsen, P., Muyldermans, S., Kjolby, M. & Andersen, O. M., Sept 2023, In: Journal of Biotechnology. 375, p. 17-27 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)23 Downloads (Pure) -
On the causal role of retromer-dependent endosomal recycling in Alzheimer’s disease
Young, J. E., Holstege, H., Andersen, O. M., Petsko, G. A. & Small, S. A., Oct 2023, In: Nature Cell Biology. 25, 10, p. 1394-1397 4 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review
7 Citations (Scopus) -
2022
A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency
Andersen, O. M., Bøgh, N., Landau, A. M., Pløen, G. G., Jensen, A. M. G., Monti, G., Ulhøi, B. P., Nyengaard, J. R., Jacobsen, K. R., Jørgensen, M. M., Holm, I. E., Kristensen, M. L., Alstrup, A. K. O., Hansen, E. S. S., Teunissen, C. E., Breidenbach, L., Droescher, M., Liu, Y., Pedersen, H. S. & Callesen, H. & 7 others, , Sept 2022, In: Cell Reports Medicine. 3, 9, 100740.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access25 Citations (Scopus) -
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease
Salasova, A., Monti, G., Andersen, O. M. & Nykjaer, A., Dec 2022, In: Molecular Neurodegeneration. 17, 1, 74.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access14 Citations (Scopus) -
Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L., Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F., Glerup, S., Nykjær, A. & Vægter, C. B., May 2022, In: Frontiers in Cellular Neuroscience. 16, 15 p., 856734.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access8 Citations (Scopus) -
The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
Mishra, S., Knupp, A., Szabo, M. P., Williams, C. A., Kinoshita, C., Hailey, D. W., Wang, Y., Andersen, O. M. & Young, J. E., Feb 2022, In: Cellular and Molecular Life Sciences. 79, 3, 22 p., 162.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile69 Citations (Scopus)20 Downloads (Pure) -
2021
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance
Al-Akhrass, H., Conway, J. R. W., Poulsen, A. S. A., Paatero, I., Kaivola, J., Padzik, A., Andersen, O. M. & Ivaska, J., 18 Feb 2021, In: Oncogene. 40, 7, p. 1300-1317 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile22 Citations (Scopus)43 Downloads (Pure) -
Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling
Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E., Patel, V., Kannan, S., Kim, Y. H., Chang, K. T., Alzheimer's Disease Neuroimaging Initiative, Hussaini, S. A., Moreno, H., Di Paolo, G., Andersen, O. M. & Small, S. A., Dec 2021, In: Cell Reports. 37, 13, 110182.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access34 Citations (Scopus) -
Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease
Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 43.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access9 Citations (Scopus) -
In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer´s Disease
Andersen, O. M., Bøgh, N., Landau, A., Pløen, G. G., Jensen, A. M. G., Monti, G., Ulhøi, B. P., Nyengaard, J. R., Jacobsen, K. R., Jørgensen, M. M., Holm, I. E., Kristensen, M. L., Søvsø Szocska Hansen, E., Teunissen, C. E., Breidenbach, L., Droescher, M., Liu, Y., Pedersen, H. S., Callesen, H. & Luo, Y. & 6 others, , 13 Jul 2021.Research output: Working paper/Preprint › Preprint
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2020
SorCS1 binds the insulin receptor to enhance insulin sensitivity
Kjolby, M., Pedersen, K. M., Breining, P., Wellner, N., Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P., Januliene, D., Manavalan, A., Rotman, M., Thotakura, G., Skeldal, S., Madsen, P., Thirup, S., Hermey, G., Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B. & Parlevliet, E. T. & 7 others, , 1 Nov 2020, bioRxiv.Research output: Working paper/Preprint › Working paper › Research
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SORLA Expression in Synaptic Plexiform Layers of Mouse Retina
Monti, G., Jensen, M. L., Mehmedbasic, A., Jørgensen, M. M., Holm, I. E., Barkholt, P., Zole, E., Vægter, C. B., Vorum, H., Nyengaard, J. R. & Andersen, O. M., 1 Jul 2020, In: Molecular Neurobiology. 57, 7, p. 3106-3117 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2019
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression
Gonçalves, N. P., Mohseni, S., El Soury, M., Ulrichsen, M., Richner, M., Xiao, J., Wood, R. J., Andersen, O. M., Coulson, E. J., Raimondo, S., Murray, S. S. & Vægter, C. B., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 235.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access21 Citations (Scopus) -
SORLA regulates endosomal trafficking and oncogenic fitness of HER2
Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N. Z., Paatero, I., Närvä, E., Al-Akhrass, H., Lilja, J., Georgiadou, M., Andersen, O. M., Padzik, A., Sihto, H., Joensuu, H., Blomqvist, M., Saarinen, I., Boström, P. J., Taimen, P. & Ivaska, J., May 2019, In: Nature Communications. 10, 1, p. 1-16 16 p., 2340.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access47 Citations (Scopus) -
Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain
Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L.-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A., 19 Jun 2019, In: Science Advances. 5, 6, 13 p., eaav9946.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access44 Citations (Scopus) -
2018
An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor
Blechingberg, J., Poulsen, A. S. A., Kjølby, M., Monti, G., Allen, M., Ivarsen, A. K., Lincoln, S. J., Thotakura, G., Vægter, C. B., Ertekin-Taner, N., Nykjær, A. & Andersen, O. M., Nov 2018, In: Neurobiology of Aging. 71, p. 266.e11-266.e24 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access11 Citations (Scopus) -
Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface
Mygind, K. J., Störiko, T., Freiberg, M. L., Samsøe-Petersen, J., Schwarz, J., Andersen, O. M. & Kveiborg, M., 25 May 2018, In: Journal of Biological Chemistry. 293, 21, p. 8077-8088 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access14 Citations (Scopus) -
2017
20 Years Anniversary for SORLA/SORL1 (1996-2016)
Monti, G. & Andersen, O. M., Dec 2017, In: Receptors and Clinical Investigation. 4, 4, p. 2-10 e1611.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2016
Aldehyder og ketoner
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Alkener, alkyner og isomeri
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Alkoholer, phenoler, ethere og thioler
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Aminer og amider
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Bindinger og molekylestruktur
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Carboxylsyrer og carboxylsyrederivater
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Energetik
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Intermolekylære bindinger og tilstandsformer
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Kemisk Ligevægt
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Kulhydrater
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Lipider
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Molekylestruktur og fysisk-kemiske egenskaber
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Nukleotider og nukleoinsyrer
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Periodesystem og støkiometri
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Reaktionskinitik og katalyse
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Reduktorer og oxidatorer
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease
Andersen, O. M., Rudolph, I.-M. & Willnow, T. E., 16 Sept 2016, In: Acta Neuropathologica. 132, 5, p. 653–665 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
12 Citations (Scopus) -
SorCS2 is required for BDNF-dependent plasticity in the hippocampus
Glerup, S., Bolcho, U., Bøggild, S., Vaegter, C. B., Smith, A. H., Nieto-Gonzalez, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., Kjolby, M., Login, H., Holm, M. M., Andersen, O. M., Nyengaard, J. R., Willnow, T. E., Jensen, K., Nykjaer, A. & Jensen, S. M., 1 Dec 2016, In: Molecular Psychiatry. 21, 12, p. 1740-1751 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
65 Citations (Scopus) -
Syrer og baser
Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 Aug 2016, Medicinsk Kemi. SystimeResearch output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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2015
Assosiations of sorLA/SORL 1 With Alzheimer`s disease
Andersen, O. M. & Thakurta, I. G., 2015Research output: Other contribution › Net publication - Internet publication › Research › peer-review
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Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA
Dienemann, C., Coburger, I., Mehmedbasic, A., Andersen, O. M. & Than, M. E., 10 Apr 2015, In: Biochemistry.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
The A-B-C for SORting APP
Coulson, E. J. & Andersen, O. M., Oct 2015, In: Journal of Neurochemistry. 135, 1, p. 1-3 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus) -
2014
Development of an improved immunoassay for detection of sorLA in cells and biological samples.
Andersen, O. M., Thakurta, I. G. & West, M. J., 13 Jul 2014.Research output: Contribution to conference › Poster › Research › peer-review
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Regulation of sorLA in general and in Alzheimer's disease
Andersen, O. M., Poulsen, A. S. A., Zole, E., Ivarsen, A. K., Blechingberg, J. & Vorum, H., 16 Jul 2014.Research output: Contribution to conference › Poster › Research › peer-review