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Niels Henrik Buus

Small artery structure is an independent predictor of cardiovascular events in essential hypertension

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  • Ole Norling Mathiassen, Denmark
  • Niels Henril Buus
  • Inger Sihm, Medicinsk-kardiologisk afd. A, Århus Sygehus, Denmark
  • Niels K Thybo, Medicinsk-kardiologisk afd., Århus Sygehus, Denmark
  • Birgitte Mørn, Medicinsk-kardiologisk afd., Århus Sygehus, Denmark
  • Anne P Schroeder, Intern Medicin, Viborg Sygehus, Denmark
  • Kristian Thygesen
  • Christian Aalkjær
  • Ole Lederballe, Intern Medicin, Viborg Sygehus, Denmark
  • Michael J. Mulvany
  • Kent Lodberg Christensen, Denmark
  • Danish Biomembrane Research Centre
  • Department of Pharmacology
  • The Department of Internal Medicine and Cardiology A
  • The Department of Medicine and Nephrology C

Objective Structural abnormality of resistance arteries

is a characteristic pathophysiological phenomenon in

essential hypertension and can be assessed in vitro as an

increase in the media : lumen ratio (M : L) of isolated small

arteries. We have investigated whether M: L is a risk

predictor in uncomplicated essential hypertensive patients.

Recently, high M: L was demonstrated as a prognostic

marker in patients at high cardiovascular risk, including

normotensive type 2 diabetic patients. Since diabetes is

associated with pressure-independent changes in M: L,

the relevance of this finding to essential hypertension has

been uncertain.

Methods We conducted a follow-up survey of 159 essential

hypertensive patients, who had previously been submitted

to a M: L evaluation while participating in a clinical trial. They

composed a homogeneous moderate-risk group, with no

concomitant diseases, and represented 1661 years of


Results Thirty patients suffered a documented predefined

cardiovascular event during follow-up. Increased relative

risk (RR) was associated withM: L>-0.083 (mean level of the

hypertensive cohort), RRU2.34 [95% confidence interval

(CI) 1.11-4.95], and with M: L>-0.098 (mean level of a

normotensive control groupR2SD), RRU2.49 (95%

CI 1.21-5.11). Both results remained significant (RRU2.19,

95% CI 1.04-4.64, and RRU2.20, 95% CI 1.06-4.56,

respectively) when adjusted for Heart Score level

(10-year mortality risk-estimate, integrating age, gender,

systolic blood pressure, cholesterol and smoking).

Conclusion Abnormal resistance artery structure

independently predicts cardiovascular events in essential

hypertensive patients at moderate risk. J Hypertens

25:1021-1026 Q 2007 Lippincott Williams & Wilkins.

Journal of Hypertension 2007, 25:1021-1026

Original languageEnglish
JournalJ Hypertension
Pages (from-to)1021–6
Number of pages6
Publication statusPublished - 2007

    Research areas

  • essential hypertension, microcirculation, prognosis, resistance

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