Niels Henrik Buus

Influence of renal transplantation and living kidney donation on large artery stiffness and peripheral vascular resistance

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  • Niels H Buus
  • Rasmus K Carlsen
  • ,
  • Alun D Hughes, Department of Population Science & Experimental Medicine, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, United Kingdom.
  • ,
  • Karin Skov

Background: Vascular status following renal transplantation (RT) may improve while living kidney donation (LKD) is possibly associated with an increased cardiovascular risk. Methods: We prospectively assessed glomerular filtration rate (mGFR, 51Chrome EDTA clearance) and intermediate vascular risk factors in terms of blood pressure (BP), pulse wave velocity (PWV), central augmentation index (AIx), excess pressure (P excess), and forearm vascular resistance in donors (n = 58, 45 ± 13 years) and recipients (n = 51, 50 ± 12 years) before and one year following LKD or RT. Results: After kidney donation, mGFR decreased by 33% to 65 ± 11 ml/min/1.73m 2, while recipients obtained a mGFR of 55 ± 9 ml/min/1.73m. 2 Ambulatory 24-hour mean arterial BP (MAP) remained unchanged in donors but decreased by 5 mm Hg in recipients (P < 0.05). Carotid-femoral PWV increased by 0.3 m/s in donors (P < 0.05) but remained unchanged in recipients. AIx was unaltered after LKD but decreased following RT (P < 0.01), and P excess did not change in either group. Resting forearm resistance (R rest), measured by venous occlusion plethysmography, increased after LKD (P < 0.05) but was unaffected by RT, while no changes were seen in minimum resistance (R min). ΔPWV showed a positive linear association to Δ24-hour MAP in both groups. Multiple linear regression analysis (adjusting for age, gender, and the baseline value of the studied parameter) did not detect independent effects of graft function on 24-hour MAP, PWV, AIx, vascular resistance, or P excess, whereas low post-donation GFR was related to higher AIx and R rest. Conclusions: RT reduced BP and AIx without affecting PWV, whereas LKD resulted in increased PWV and R rest, despite unchanged BP.

Original languageEnglish
JournalAmerican Journal of Hypertension
Pages (from-to)234-242
Number of pages9
Publication statusPublished - Mar 2020

    Research areas

  • blood pressure, hypertension, living kidney donation, pulse wave velocity, renal recipients, renal transplantation, vascular resistance, INDEPENDENT PREDICTOR, CARDIOVASCULAR EVENTS, DONORS, AORTIC STIFFNESS, ATENOLOL, WAVE REFLECTIONS, SYSTOLIC BLOOD-PRESSURE, REDUCTION, DISEASE, HYPERTENSION

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