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Nicklas Vinter

Quality of care and risk of incident atrial fibrillation in patients with newly-diagnosed heart failure: A nationwide cohort study

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  • Nicklas Vinter
  • Pia Cordsen, Aalborg University
  • ,
  • Morten Fenger-Grøn
  • ,
  • Gregory Y H Lip, University of Liverpool, Liverpool Heart and Chest Hospital, Aalborg University
  • ,
  • Emelia J Benjamin, Boston University
  • ,
  • Lars Frost
  • Søren Paaske Johnsen, Boston University

AIMS: Incident atrial fibrillation (AF) is an adverse prognostic indicator in heart failure (HF); identifying modifiable targets may be relevant to reduce the incidence and morbidity of AF. Therefore, we examined the association between quality of HF care and risk of AF.

METHODS AND RESULTS: Using the Danish Heart Failure Registry, we conducted a nationwide registry-based cohort study of all incident HF patients diagnosed between 2008 and 2018 and without history of AF. Quality of HF care was assessed by seven process performance measures, including echocardiographic examination, New York Heart Association classification, treatment with angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, beta-blockers, and mineralocorticoid antagonists, physical training, and patient education. In the main analysis, we examined adherence with all measures in a cohort of 25,100 patients (mean age 68.5 ± 13.2 years; 33.6% women). The median follow-up was 3.1 years. Cox proportional hazard regressions estimated the hazard ratios (HRs) with 95% confidence intervals (95% CIs) between the number of fulfilled measures and incident AF. In a multivariable-adjusted analysis with 0 fulfilled performance measures as reference, the HRs (95% CIs) were 1: 0.78 (0.61-1.00), 2: 0.63 (0.49-0.80), 3: 0.53 (0.36-0.80), 4: 0.64 (0.44-0.94), 5: 0.56 (0.39-0.82), 6: 0.51 (0.35-0.74), and 7: 0.49 (0.33-0.73), with a significant decreasing linear trend (p < 0.001).

CONCLUSION: In patients with incident HF, fulfillment of guideline-based process performance measures was associated with decreased long-term risk of AF. This study supports initiatives to improve the quality of care for patients with HF to prevent incident AF.

Original languageEnglish
JournalEuropean heart journal. Quality of care & clinical outcomes
Pages (from-to)539–547
Number of pages9
Publication statusPublished - Sept 2022

    Research areas

  • Atrial fibrillation, GUIDELINES, Heart failure, LIFETIME RISK, PERFORMANCE, PREVALENCE, Process performance measure, Quality indicators, Quality of health care, REGISTRY, Angiotensin Receptor Antagonists, Humans, Middle Aged, Heart Failure/complications, Male, Adrenergic beta-Antagonists/therapeutic use, Aged, 80 and over, Female, Aged, Atrial Fibrillation/complications, Cohort Studies

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