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Nick Stub Laursen

Highly conserved protective epitopes on influenza B viruses

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DOI

  • Cyrille Dreyfus, Department of Molecular Biology, The Scripps Research Institute, United States
  • Nick S Laursen
  • Ted Kwaks, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • David Zuijdgeest, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Reza Khayat, Department of Molecular Biology, The Scripps Research Institute, United States
  • Damian C Ekiert, Department of Molecular Biology, The Scripps Research Institute, United States
  • Jeong Hyun Lee, Department of Molecular Biology, The Scripps Research Institute, United States
  • Zoltan Metlagel, Department of Molecular Biology, The Scripps Research Institute, United States
  • Miriam V Bujny, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Mandy Jongeneelen, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Remko van der Vlugt, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Mohammed Lamrani, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Hans J W M Korse, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Eric Geelen, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Özcan Sahin, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Martijn Sieuwerts, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Just P J Brakenhoff, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Ronald Vogels, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Olive T W Li, State Key Laboratory of Emerging Infectious Diseases and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
  • Leo L M Poon, State Key Laboratory of Emerging Infectious Diseases and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
  • Malik Peiris, State Key Laboratory of Emerging Infectious Diseases and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
  • Wouter Koudstaal, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Andrew B Ward, Department of Molecular Biology, The Scripps Research Institute, United States
  • Ian A Wilson, Department of Molecular Biology, The Scripps Research Institute, United States
  • Jaap Goudsmit, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands
  • Robert H E Friesen, Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Netherlands

Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.

Original languageEnglish
JournalScience
Volume337
Issue6100
Pages (from-to)1343-1248
Number of pages6
ISSN0036-8075
DOIs
Publication statusPublished - 14 Sep 2012
Externally publishedYes

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