Nick Stub Laursen

  1. 2022
  2. Accepted/In press

    Nanobody-based human antibody formats act as IgE surrogate in hymenoptera venom allergy. / Aagaard, Josephine Baunvig; Sivelle, Coline; Fischer, Michaela et al.

    In: Allergy: European Journal of Allergy and Clinical Immunology, 2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. 2021
  4. Published

    Nanobodies provide insight into the molecular mechanisms of the complement cascade and offer new therapeutic strategies. / Zarantonello, Alessandra; Pedersen, Henrik; Laursen, Nick S. et al.

    In: Biomolecules, Vol. 11, No. 2, 298, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  5. 2020
  6. Published

    A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. / Pedersen, Henrik; Jensen, Rasmus K; Jensen, Jens Magnus B et al.

    In: Journal of Immunology, Vol. 205, No. 8, 10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Complement activation by human IgG antibodies to galactose-α-1,3-galactose. / Bernth Jensen, Jens Magnus; Laursen, Nick Stub; Kjeldsen Jensen, Rasmus et al.

    In: Immunology, Vol. 161, No. 1, 09.2020, p. 66-79.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Structural signatures in EPR3 define a unique class of plant carbohydrate receptors. / Wong, Jaslyn E.M.M.; Gysel, Kira; Birkefeldt, Thea G. et al.

    In: Nature Communications, Vol. 11, 3797, 07.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system. / Pedersen, Henrik; Jensen, Rasmus K; Hansen, Annette G et al.

    In: The Journal of Biological Chemistry, Vol. 295, No. 26, 06.2020, p. 8746-8758.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. / Mortensen, Michael R.; Skovsgaard, Mikkel B.; Märcher, Anders et al.

    In: Bioconjugate Chemistry, Vol. 31, No. 5, 05.2020, p. 1295-1300.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. / Zarantonello, Alessandra; Presumey, Jessy; Simoni, Léa et al.

    In: Journal of Immunology, Vol. 205, No. 6, 2020, p. 1678-1694.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System. / Laursen, Nick S.; Pedersen, Dennis V.; Gytz, Heidi et al.

    In: Frontiers in Immunology, Vol. 11, 1504, 2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement. / Pedersen, Dennis V; Rösner, Thies; Hansen, Annette G et al.

    In: Molecular Immunology, Vol. 124, 2020, p. 200-210.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. 2019
  15. Published

    Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. / Pedersen, Dennis V; Gadeberg, Trine A F; Thomas, Caroline et al.

    In: Frontiers in Immunology, Vol. 10, 2007, 08.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. 2018
  17. Published

    Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase. / Longhin, Elena; Grønberg, Christina; Hu, Qiaoxia et al.

    In: Antibodies, Vol. 7, No. 4, 39, 07.11.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. / Laursen, Nick S.; Friesen, Robert H.E.; Zhu, Xueyong et al.

    In: Science, Vol. 362, No. 6414, 02.11.2018, p. 598-602.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. / Jensen, Rasmus K; Pihl, Rasmus; Gadeberg, Trine A F et al.

    In: Journal of Biological Chemistry, Vol. 293, No. 17, 27.04.2018, p. 6269-6281.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction. / Jabs, Frederic; Plum, Melanie; Laursen, Nick Stub et al.

    In: Nature Communications, Vol. 9, No. 1, 7, 02.01.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. 2017
  22. Published

    A novel nanobody inhibitor of the alternative pathway. / Jensen, Rasmus Kjeldsen; Pihl, Rasmus; Laursen, Nick Stub et al.

    In: Molecular Immunology, Vol. 89, 09.2017, p. 198.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  23. Published

    An anti-IgE single domain antibody disrupts the interaction of IgE with fceri by acting as functional high affinity mimic of cd23. / Jabs, F.; Plum, M.; Laursen, N. S. et al.

    In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 72, No. Suppl. 103 SI, 0138, 08.2017, p. 13-13.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  24. Published

    Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures. / Hansen, Simon Boje; Laursen, Nick Stub; Andersen, Gregers Rom et al.

    In: Acta crystallographica Section D: Structural biology , Vol. 73, No. Pt 10, 2017, p. 804-813.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. 2015
  26. Published

    A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. / Impagliazzo, Antonietta; Milder, Fin; Kuipers, Harmjan et al.

    In: Science, Vol. 349, No. 6254, 18.09.2015, p. 1301-1306.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. 2013
  28. Published

    Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site. / Hong, Minsun; Lee, Peter S; Hoffman, Ryan M B et al.

    In: Journal of Virology, Vol. 87, No. 22, 11.2013, p. 12471-12480.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Broadly neutralizing antibodies against influenza viruses. / Laursen, Nick S; Wilson, Ian A.

    In: Antiviral Research, Vol. 98, No. 3, 06.2013, p. 476-483.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. 2012
  31. Published

    Structural basis for activation of the complement system by component C4 cleavage. / Kidmose, Rune T; Laursen, Nick S; Dobó, József et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 38, 18.09.2012, p. 15425-15430.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Highly conserved protective epitopes on influenza B viruses. / Dreyfus, Cyrille; Laursen, Nick S; Kwaks, Ted et al.

    In: Science, Vol. 337, No. 6100, 14.09.2012, p. 1343-1248.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Structure, function and control of complement C5 and its proteolytic fragments. / Laursen, Nick Stub; Magnani, Francesca; Gottfredsen, Randi H et al.

    In: Current Molecular Medicine, Vol. 12, No. 8, 08.09.2012, p. 1083-1097.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2011
  35. Published

    Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. / Laursen, Nick Stub; Andersen, Kasper Røjkjær; Braren, Ingke et al.

    In: E M B O Journal, Vol. 30, No. 3, 02.02.2011, p. 606-616.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. 2010
  37. Published

    Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. / Laursen, Nick Stub; Gordon, Natasha; Lorenz, Natalie et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 8, 2010, p. 3681-3686.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. 2008
  39. Published

    Structure of and influence of a tick complement inhibitor on human complement component 5. / Fredslund, Folmer; Laursen, Nick S; Roversi, Pietro et al.

    In: Nature Immunology, Vol. 9, No. 7, 07.2008, p. 753-60.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review