Nick Stub Laursen

  1. 2021
  2. Published

    Nanobodies provide insight into the molecular mechanisms of the complement cascade and offer new therapeutic strategies. / Zarantonello, Alessandra; Pedersen, Henrik; Laursen, Nick S.; Andersen, Gregers R.

    In: Biomolecules, Vol. 11, No. 2, 298, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. 2020
  4. Published

    A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. / Pedersen, Henrik; Jensen, Rasmus K; Jensen, Jens Magnus B; Fox, Rachel; Pedersen, Dennis V; Olesen, Heidi G; Hansen, Annette G; Christiansen, Dorte; Mazarakis, Sofia M M; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A F; Zarantonello, Alessandra; Laursen, Nick S; Mollnes, Tom Eirik; Johnson, Matthew B; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R.

    In: Journal of Immunology, Vol. 205, No. 8, 10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Structural signatures in EPR3 define a unique class of plant carbohydrate receptors. / Wong, Jaslyn E.M.M.; Gysel, Kira; Birkefeldt, Thea G.; Vinther, Maria; Muszyński, Artur; Azadi, Parastoo; Laursen, Nick S.; Sullivan, John T.; Ronson, Clive W.; Stougaard, Jens; Andersen, Kasper R.

    In: Nature Communications, Vol. 11, 3797, 07.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system. / Pedersen, Henrik; Jensen, Rasmus K; Hansen, Annette G; Gadeberg, Trine A F; Thiel, Steffen; Laursen, Nick S; Andersen, Gregers.

    In: The Journal of Biological Chemistry, Vol. 295, No. 26, 06.2020, p. 8746-8758.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. / Mortensen, Michael R.; Skovsgaard, Mikkel B.; Märcher, Anders; Andersen, Veronica L.; Palmfeldt, Johan; Nielsen, Thorbjørn B.; Tørring, Thomas; Laursen, Nick S.; Andersen, Kasper R.; Kjems, Jørgen; Gothelf, Kurt V.

    In: Bioconjugate Chemistry, Vol. 31, No. 5, 05.2020, p. 1295-1300.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. / Zarantonello, Alessandra; Presumey, Jessy; Simoni, Léa; Yalcin, Esra; Fox, Rachel; Hansen, Annette; Olesen, Heidi Gytz; Thiel, Steffen; Johnson, Matthew B; Stevens, Beth; Laursen, Nick Stub; Carroll, Michael C; Andersen, Gregers R.

    In: Journal of Immunology, Vol. 205, No. 6, 2020, p. 1678-1694.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Complement activation by human IgG antibodies to galactose-α-1,3-galactose. / Bernth Jensen, Jens Magnus; Laursen, Nick Stub; Kjeldsen Jensen, Rasmus; Andersen, Gregers Rom; Jensenius, Jens Christian; Skov Sørensen, Uffe B; Thiel, Steffen.

    In: Immunology, Vol. 161, No. 1, 2020, p. 66-79.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System. / Laursen, Nick S.; Pedersen, Dennis V.; Gytz, Heidi; Zarantonello, Alessandra; Bernth Jensen, Jens Magnus; Hansen, Annette G.; Thiel, Steffen; Andersen, Gregers R.

    In: Frontiers in Immunology, Vol. 11, 1504, 2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement. / Pedersen, Dennis V; Rösner, Thies; Hansen, Annette G; Andersen, Kasper R; Thiel, Steffen; Andersen, Gregers R; Valerius, Thomas; Laursen, Nick S.

    In: Molecular Immunology, Vol. 124, 2020, p. 200-210.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. 2019
  13. Published

    Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. / Pedersen, Dennis V; Gadeberg, Trine A F; Thomas, Caroline; Joram, Nicolas; Jensen, Rasmus K; Mazarakis, Sofia M M; Revel, Margot; El Sissy, Carine; Petersen, Steen V; Lindorff-Larsen, Kresten; Thiel, Steffen; Laursen, Nick S; Fremeaux-Bacchi, Véronique; Andersen, Gregers R.

    In: Frontiers in Immunology, Vol. 10, 2007, 08.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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