Nick Stub Laursen

  1. Journal article
  2. Published

    Complement activation by human IgG antibodies to galactose-α-1,3-galactose. / Bernth Jensen, Jens Magnus; Laursen, Nick Stub; Kjeldsen Jensen, Rasmus; Andersen, Gregers Rom; Jensenius, Jens Christian; Skov Sørensen, Uffe B; Thiel, Steffen.

    In: Immunology, Vol. 161, No. 1, 2020, p. 66-79.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    Highly conserved protective epitopes on influenza B viruses. / Dreyfus, Cyrille; Laursen, Nick S; Kwaks, Ted; Zuijdgeest, David; Khayat, Reza; Ekiert, Damian C; Lee, Jeong Hyun; Metlagel, Zoltan; Bujny, Miriam V; Jongeneelen, Mandy; van der Vlugt, Remko; Lamrani, Mohammed; Korse, Hans J W M; Geelen, Eric; Sahin, Özcan; Sieuwerts, Martijn; Brakenhoff, Just P J; Vogels, Ronald; Li, Olive T W; Poon, Leo L M; Peiris, Malik; Koudstaal, Wouter; Ward, Andrew B; Wilson, Ian A; Goudsmit, Jaap; Friesen, Robert H E.

    In: Science, Vol. 337, No. 6100, 14.09.2012, p. 1343-1248.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Den rummelige opbygning af proteiner fra immunforsvaret. / Fredslund, Folmer; Laursen, Nick Stub; Sottrup-Jensen, Lars; Andersen, Gregers Rom.

    In: Dansk Kemi, Vol. 89, 2008, p. 44-48.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  5. Published

    Structure of and influence of a tick complement inhibitor on human complement component 5. / Fredslund, Folmer; Laursen, Nick S; Roversi, Pietro; Jenner, Lasse Bohl; Oliveira, Cristiano L P; Pedersen, Jan S; Nunn, Miles A; Lea, Susan M; Discipio, Richard; Sottrup-Jensen, Lars; Andersen, Gregers Rom.

    In: Nature Immunology, Vol. 9, No. 7, 07.2008, p. 753-60.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures. / Hansen, Simon Boje; Laursen, Nick Stub; Andersen, Gregers Rom; Andersen, Kasper R.

    In: Acta crystallographica Section D: Structural biology , Vol. 73, No. Pt 10, 2017, p. 804-813.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site. / Hong, Minsun; Lee, Peter S; Hoffman, Ryan M B; Zhu, Xueyong; Krause, Jens C; Laursen, Nick S; Yoon, Sung-Il; Song, Langzhou; Tussey, Lynda; Crowe, James E; Ward, Andrew B; Wilson, Ian A.

    In: Journal of Virology, Vol. 87, No. 22, 11.2013, p. 12471-12480.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. / Impagliazzo, Antonietta; Milder, Fin; Kuipers, Harmjan; Wagner, Michelle V; Zhu, Xueyong; Hoffman, Ryan M B; van Meersbergen, Ruud; Huizingh, Jeroen; Wanningen, Patrick; Verspuij, Johan; de Man, Martijn; Ding, Zhaoqing; Apetri, Adrian; Kükrer, Başak; Sneekes-Vriese, Eveline; Tomkiewicz, Danuta; Laursen, Nick S; Lee, Peter S; Zakrzewska, Anna; Dekking, Liesbeth; Tolboom, Jeroen; Tettero, Lisanne; van Meerten, Sander; Yu, Wenli; Koudstaal, Wouter; Goudsmit, Jaap; Ward, Andrew B; Meijberg, Wim; Wilson, Ian A; Radošević, Katarina.

    In: Science, Vol. 349, No. 6254, 18.09.2015, p. 1301-1306.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction. / Jabs, Frederic; Plum, Melanie; Laursen, Nick Stub; Jensen, Rasmus Kjeldsen; Mølgaard, Brian; Miehe, Michaela; Mandolesi, Marco; Rauber, Michéle M.; Pfützner, Wolfgang; Jakob, Thilo; Möbs, Christian; Andersen, Gregers Rom; Spillner, Edzard.

    In: Nature Communications, Vol. 9, No. 1, 7, 02.01.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. / Jensen, Rasmus K; Pihl, Rasmus; Gadeberg, Trine A F; Jensen, Jan K; Andersen, Kasper R; Thiel, Steffen; Laursen, Nick S; Andersen, Gregers Rom.

    In: Journal of Biological Chemistry, Vol. 293, No. 17, 27.04.2018, p. 6269-6281.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Structural basis for activation of the complement system by component C4 cleavage. / Kidmose, Rune T; Laursen, Nick S; Dobó, József; Kjaer, Troels R; Sirotkina, Sofia; Yatime, Laure; Sottrup-Jensen, Lars; Thiel, Steffen; Gál, Péter; Andersen, Gregers Rom.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 38, 18.09.2012, p. 15425-15430.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Broadly neutralizing antibodies against influenza viruses. / Laursen, Nick S; Wilson, Ian A.

    In: Antiviral Research, Vol. 98, No. 3, 06.2013, p. 476-483.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System. / Laursen, Nick S.; Pedersen, Dennis V.; Gytz, Heidi; Zarantonello, Alessandra; Bernth Jensen, Jens Magnus; Hansen, Annette G.; Thiel, Steffen; Andersen, Gregers R.

    In: Frontiers in Immunology, Vol. 11, 1504, 2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. / Laursen, Nick Stub; Gordon, Natasha; Lorenz, Natalie; Jackson, Nicola; Wines, Bruce; Spillner, Edzard; Christensen, Jesper Bjerg; Jensen, Morten; Fredslund, Folmer; Bjerre, Mette; Sottrup-Jensen, Lars; Fraser, John; Andersen, Gregers Rom.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 8, 2010, p. 3681-3686.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Structure, function and control of complement C5 and its proteolytic fragments. / Laursen, Nick Stub; Magnani, Francesca; Gottfredsen, Randi H; Petersen, Steen V; Andersen, Gregers Rom.

    In: Current Molecular Medicine, Vol. 12, No. 8, 08.09.2012, p. 1083-1097.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. / Laursen, Nick Stub; Andersen, Kasper Røjkjær; Braren, Ingke; Spilllner, Edzard; Sottrup-Jensen, Lars; Andersen, Gregers Rom.

    In: E M B O Journal, Vol. 30, No. 3, 02.02.2011, p. 606-616.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. / Laursen, Nick S.; Friesen, Robert H.E.; Zhu, Xueyong; Jongeneelen, Mandy; Blokland, Sven; Vermond, Jan; Van Eijgen, Alida; Tang, Chan; Van Diepen, Harry; Obmolova, Galina; Van Der Neut Kolfschoten, Marijn; Zuijdgeest, David; Straetemans, Roel; Hoffman, Ryan M.B.; Nieusma, Travis; Pallesen, Jesper; Turner, Hannah L.; Bernard, Steffen M.; Ward, Andrew B.; Luo, Jinquan; Poon, Leo L.M.; Tretiakova, Anna P.; Wilson, James M.; Limberis, Maria P.; Vogels, Ronald; Brandenburg, Boerries; Kolkman, Joost A.; Wilson, Ian A.

    In: Science, Vol. 362, No. 6414, 02.11.2018, p. 598-602.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase. / Longhin, Elena; Grønberg, Christina; Hu, Qiaoxia; Duelli, Annette Susanne; Andersen, Kasper Røjkjær; Laursen, Nick Stub; Gourdon, Pontus.

    In: Antibodies, Vol. 7, No. 4, 39, 07.11.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. / Mortensen, Michael R.; Skovsgaard, Mikkel B.; Märcher, Anders; Andersen, Veronica L.; Palmfeldt, Johan; Nielsen, Thorbjørn B.; Tørring, Thomas; Laursen, Nick S.; Andersen, Kasper R.; Kjems, Jørgen; Gothelf, Kurt V.

    In: Bioconjugate Chemistry, Vol. 31, No. 5, 05.2020, p. 1295-1300.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system. / Pedersen, Henrik; Jensen, Rasmus K; Hansen, Annette G; Gadeberg, Trine A F; Thiel, Steffen; Laursen, Nick S; Andersen, Gregers.

    In: The Journal of Biological Chemistry, Vol. 295, No. 26, 06.2020, p. 8746-8758.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. / Pedersen, Henrik; Jensen, Rasmus K; Jensen, Jens Magnus B; Fox, Rachel; Pedersen, Dennis V; Olesen, Heidi G; Hansen, Annette G; Christiansen, Dorte; Mazarakis, Sofia M M; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A F; Zarantonello, Alessandra; Laursen, Nick S; Mollnes, Tom Eirik; Johnson, Matthew B; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R.

    In: Journal of Immunology, Vol. 205, No. 8, 10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement. / Pedersen, Dennis V; Rösner, Thies; Hansen, Annette G; Andersen, Kasper R; Thiel, Steffen; Andersen, Gregers R; Valerius, Thomas; Laursen, Nick S.

    In: Molecular Immunology, Vol. 124, 2020, p. 200-210.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. / Pedersen, Dennis V; Gadeberg, Trine A F; Thomas, Caroline; Joram, Nicolas; Jensen, Rasmus K; Mazarakis, Sofia M M; Revel, Margot; El Sissy, Carine; Petersen, Steen V; Lindorff-Larsen, Kresten; Thiel, Steffen; Laursen, Nick S; Fremeaux-Bacchi, Véronique; Andersen, Gregers R.

    In: Frontiers in Immunology, Vol. 10, 2007, 08.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Structural signatures in EPR3 define a unique class of plant carbohydrate receptors. / Wong, Jaslyn E.M.M.; Gysel, Kira; Birkefeldt, Thea G.; Vinther, Maria; Muszyński, Artur; Azadi, Parastoo; Laursen, Nick S.; Sullivan, John T.; Ronson, Clive W.; Stougaard, Jens; Andersen, Kasper R.

    In: Nature Communications, Vol. 11, 3797, 07.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. / Zarantonello, Alessandra; Presumey, Jessy; Simoni, Léa; Yalcin, Esra; Fox, Rachel; Hansen, Annette; Olesen, Heidi Gytz; Thiel, Steffen; Johnson, Matthew B; Stevens, Beth; Laursen, Nick Stub; Carroll, Michael C; Andersen, Gregers R.

    In: Journal of Immunology, Vol. 205, No. 6, 2020, p. 1678-1694.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Review
  27. Published

    Nanobodies provide insight into the molecular mechanisms of the complement cascade and offer new therapeutic strategies. / Zarantonello, Alessandra; Pedersen, Henrik; Laursen, Nick S.; Andersen, Gregers R.

    In: Biomolecules, Vol. 11, No. 2, 298, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  28. Conference abstract in journal
  29. Published

    An anti-IgE single domain antibody disrupts the interaction of IgE with fceri by acting as functional high affinity mimic of cd23. / Jabs, F.; Plum, M.; Laursen, N. S.; Jensen, R.; Miehe, M.; Moebs, C.; Pfuetzner, W.; Jakob, T.; Andersen, G. R.; Spillner, E.

    In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 72, No. Suppl. 103 SI, 0138, 08.2017, p. 13-13.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  30. Published

    A novel nanobody inhibitor of the alternative pathway. / Jensen, Rasmus Kjeldsen; Pihl, Rasmus; Laursen, Nick Stub; Thiel, Steffen; Andersen, Gregers Rom.

    In: Molecular Immunology, Vol. 89, 09.2017, p. 198.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  31. Ph.D. thesis
  32. Published

    Structural studies of complement C5 activation and inhibition. / Laursen, Nick Stub.

    2011.

    Research output: Book/anthology/dissertation/reportPh.D. thesisResearch