Research output per year
Research output per year
- 1 - 50 out of 64 results
Search results
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2024
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P. L., Schmidt, V., Madsen, L. S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M. N., Romero-Ramos, M., Holm, C. K., Andersen, G. R., Zhao, H., Schuck, P., Nygaard, J. V., Sutherland, D. S., Eskildsen, S. F. & Willnow, T. E. & 2 others, , Feb 2024, In: Nature Communications. 15, 1, 20 p., 1224.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K., Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S., Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J. & Nielsen, M. A. & 3 others, , Jun 2024, In: npj Parkinson's Disease . 10, 1, 139.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2023
Betrayal of the Markers
Jeyaseelan, T., Romero-Ramos, M. & Petersen, C. C., Sept 2023, In: Cytometry. Part A. 103, 9, p. 692-694 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review
Open Access -
Editorial: Updates on inflammation in Parkinson's disease
Dzamko, N., Romero-Ramos, M. & Thaler, A., Jan 2023, In: Frontiers in Neurology. 14, 2 p., 1138543.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
Open Access -
Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells
Maimaitili, M., Chen, M., Febbraro, F., Ucuncu, E., Kelly, R., Niclis, J. C., Christiansen, J. R., Mermet-Joret, N., Niculescu, D., Lauritsen, J., Iannielli, A., Klæstrup, I. H., Jensen, U. B., Qvist, P., Nabavi, S., Broccoli, V., Nykjær, A., Romero-Ramos, M. & Denham, M., Dec 2023, In: Nature Communications. 14, 1, 23 p., 7871.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson's disease
Almeida Ferreira, S. R., Li, C., Klæstrup, I. H., Vitic, Z., Rasmussen, R. K., Kirkegaard, A., Toft, G. U., Betzer, C., Svendsen, P., Jensen, P. H., Luo, Y., Etzerodt, A., Moestrup, S. K. & Romero-Ramos, M., 13 Dec 2023, In: npj Parkinson's Disease . 9, 1, p. 164 164.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
The systemic immune response in Parkinson's disease: focus on the peripheral immune component
Lauritsen, J. & Romero-Ramos, M., Oct 2023, In: Trends in Neurosciences. 46, 10, p. 863-878 16 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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2022
Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson's disease and cognition
Konstantin Nissen, S., Farmen, K., Carstensen, M., Schulte, C., Goldeck, D., Brockmann, K. & Romero‐Ramos, M., Mar 2022, In: Brain, Behavior, and Immunity. 101, p. 182-193 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile41 Downloads (Pure) -
Impact of aging on animal models of Parkinson´s disease
Klæstrup, I. H., Pedersen, M. K. J., Holm, K. L., Alstrup, A. K. O., Romero-Ramos, M., Borghammer, P. & Van Den Berge, N., Aug 2022, In: Frontiers in Aging Neuroscience. 14, 21 p., 909273.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring
Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E., Sept 2022, In: Journal of Neuroimmunology. 370, 12 p., 577927.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile50 Downloads (Pure) -
Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies
Terkelsen, M. H., Klæstrup, I. H., Hvingelby, V., Lauritsen, J., Pavese, N. & Romero-Ramos, M., Sept 2022, In: Journal of Parkinson's Disease. 12, s1, p. S149-S163Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access -
2021
Immune response during idiopathic Parkinson's disease: From humans to animal models
Nissen, S. K., Almeida Ferreira, S. R., Klæstrup, I. H. & Romero-Ramos, M., Nov 2021, Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease. London: Academic Press, p. 261-301 (International Review of Movement Disorders, Vol. 2).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research
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In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET
Thomsen, M., Jacobsen, J., Lillethorup, T. P., Schacht, A. C., Simonsen, M. I. T., Romero-Ramos, M., Brooks, D. J. & Landau, A., Apr 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 4, p. 819-830 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder
Farmen, K., Nissen, S. K., Stokholm, M. G., Iranzo, A., Østergaard, K., Serradell, M., Otto, M., Svendsen, K. B., Garrido, A., Vilas, D., Borghammer, P., Santamaria, J., Møller, A., Gaig, C., Brooks, D. J., Tolosa, E., Pavese, N. & Romero-Ramos, M., Mar 2021, In: Proceedings of the National Academy of Sciences. 118, 10, 7 p., e2020858118.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Ferreira, N., Gram, H., Sorrentino, Z. A., Gregersen, E., Schmidt, S. I., Reimer, L., Betzer, C., Perez-Gozalbo, C., Beltoja, M., Nagaraj, M., Wang, J., Nowak, J. S., Dong, M., Willén, K., Cholak, E., Bjerregaard-Andersen, K., Mendez, N., Rabadia, P., Shahnawaz, M. & Soto, C. & 5 others, , Jul 2021, In: Acta Neuropathologica. 142, p. 87-115Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile124 Downloads (Pure) -
Periphery and brain, innate and adaptive immunity in Parkinson's disease
Harms, A. S., Ferreira, S. A. & Romero-Ramos, M., Apr 2021, In: Acta Neuropathologica. 141, 4, p. 527-545 19 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile51 Downloads (Pure) -
PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats
Thomsen, M. B., Ferreira, S. A., Schacht, A. C., Jacobsen, J., Simonsen, M., Betzer, C., Jensen, P. H., Brooks, D. J., Landau, A. M. & Romero-Ramos, M., Feb 2021, In: Neurobiology of Disease. 149, 17 p., 105229.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease
Nissen, S. K., Ferreira, S. A., Nielsen, M. C., Schulte, C., Shrivastava, K., Hennig, D., Etzerodt, A., Graversen, J. H., Berg, D., Maetzler, W., Panhelainen, A., Møller, H. J., Brockmann, K. & Romero-Ramos, M., Apr 2021, In: Movement Disorders. 36, 4, p. 963-976 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease
Stokholm, K., Thomsen, M. B., Phan, J. A., Møller, L. K., Bay-Richter, C., Christiansen, S. H., Woldbye, D. P. D., Romero-Ramos, M. & Landau, A. M., Dec 2021, In: Biomedicines. 9, 12, 1876.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2020
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4
Juul-Madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B., Howard, K., Dehesa-Etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-Ramos, M. & Vorup-Jensen, T., 2020, In: Journal of Immunology. 204, 5, p. 1345-1361 17 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2019
Alterations in Blood Monocyte Functions in Parkinson's Disease
Nissen, S. K., Shrivastava, K., Schulte, C., Otzen, D. E., Goldeck, D., Berg, D., Møller, H. J., Maetzler, W. & Romero-Ramos, M., Nov 2019, In: Movement Disorders. 34, 11, p. 1711-1721 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Immune system responses in Parkinson's Disease: early and dynamic
Tansey, M. G. & Romero-Ramos, M., Feb 2019, In: The European journal of neuroscience. 49, 3, p. 364-383 20 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access -
2018
CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology
Olesen, M. N., Christiansen, J. R., Petersen, S. V., Jensen, P. H., Paslawski, W., Romero-Ramos, M. & Sanchez-Guajardo, V., 11 Jan 2018, In: Heliyon. 4, 1, 43 p., e00513.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile169 Downloads (Pure) -
Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention
Ferreira, S. A. & Romero-Ramos, M., 2018, In: Frontiers in Cellular Neuroscience. 12, p. 247 247.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies
Refolo, V., Bez, F., Polissidis, A., Kuzdas-Wood, D., Sturm, E., Kamaratou, M., Poewe, W., Stefanis, L., Angela Cenci, M., Romero-Ramos, M., Wenning, G. K. & Stefanova, N., 3 Jan 2018, In: Acta Neuropathologica Communications. 6, 1, p. 2 1 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2017
Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration
Jimenez-Ferrer, I., Jewett, M., Tontanahal, A., Romero-Ramos, M. & Swanberg, M., Oct 2017, In: Neurobiology of Disease. 106, p. 279-290 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease
Phan, J.-A., Stokholm, K., Zareba-Paslawska, J., Jakobsen, S., Vang, K., Gjedde, A., Landau, A. M. & Romero-Ramos, M., 25 Jul 2017, In: Scientific Reports. 7, 1, 6363.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2016
Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model
Tentillier, N., Etzerodt, A., Olesen, M. N., Rizalar, F. S., Jacobsen, J., Bender, D., Moestrup, S. K. & Romero-Ramos, M., 7 Sept 2016, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36, 36, p. 9375-90 16 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology
Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V., 9 Apr 2016, In: Journal of Neuroinflammation. 13, 1, 74.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2015
The relation between α-synuclein and microglia in Parkinson's Disease: Recent developments
Sanchez-Guajardo, V., Tentillier, N. & Romero-Ramos, M., 12 Feb 2015, In: Neuroscience.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2014
Alpha synuclein in Parkinson's disease
Kragh, C. L., Romero-Ramos, M., Halliday, G. M. & Jensen, P. H., 2014, Handbook of Neurotoxicity. Kostrzewa, R. M. (ed.). New York: Springer Science+Business Media, p. 691-726Research output: Contribution to book/anthology/report/proceeding › Review
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Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line
Delenclos, M., Carrascal, L., Jensen, K. & Romero-Ramos, M., 1 Aug 2014, In: Neuroscience.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Vaccination strategies for Parkinson disease: Induction of a swift attack or raising tolerance?
Romero-Ramos, M., von Euler Chelpin, M. & Sanchez-Guajardo, V., 26 Mar 2014, In: Human Vaccines & Immunotherapeutics. 10, 4Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2013
Chronic Intranasal Deferoxamine Ameliorates Motor Defects and Pathology in the α-Synuclein rAAV Parkinson's Model
Febbraro, F., Andersen, K. J., Sanchez-Guajardo, V. M., Tentillier, N. & Romero-Ramos, M., 23 Mar 2013, In: Experimental Neurology.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity
Sanchez-Guajardo, V., Barnum, C. J., Tansey, M. G. & Romero-Ramos, M., 19 Mar 2013, In: A S N Neuro.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Noradrenergic Protection of Dopaminergic Transmission in Parkinson's Disease
Phan, J.-A., Landau, A. M., Gjedde, A. & Romero-Ramos, M., 2013.Research output: Contribution to conference › Poster › Research
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Ser129D mutant alpha-Synuclein induces earlier Motor Dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's Disease
Febbraro, F., Sahin, G., Farran, A., Soares, S., Jensen, P. H., Kirik, D. & Romero-Ramos, M., 13 Aug 2013, In: Neurobiology of Disease. 56, p. 47-58Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model
Sanchez-Guajardo, V., Annibali, A., Jensen, P. H. & Romero-Ramos, M., Jul 2013, In: Journal of Neuropathology and Experimental Neurology. 72, 7, p. 624-45 22 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2012
Long-term polarization of microglia upon alpha-synuclein overexpression in nonhuman primates
Barkholt, P., Sanchez-Guajardo, V. M., Kirik, D. & Romero-Ramos, M., 2012, In: Neuroscience. 208, p. 85-96Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
File356 Downloads (Pure) -
α-Synuclein expression is modulated at the translational level by iron
Febbraro, F., Giorgi, M., Caldarola, S., Loreni, F. & Romero-Ramos, M., 2012, In: NeuroReport. 23, 9, p. 576-80 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2011
Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain
Bøttger, P., Tracz, Z., Heuck, A., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K., 1 Feb 2011, In: Journal of Comparative Neurology. 519, 2, p. 376-404 29 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease
Decressac, M., Ulusoy, A., Mattsson, B., Georgievska, B., Romero-Ramos, M., Kirik, D. & Björklund, A., 2011, In: Brain. 134, Pt 8, p. 2302-11 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Study of the role of calcium in the alpha-synuclein induced neuropathology
Zareba, J., Romero-Ramos, M. & Jensen, K., 2011.Research output: Contribution to conference › Conference abstract for conference › Research
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2010
Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
Ulusoy, A., Febbraro, F., Jensen, P. H., Kirik, D. & Romero-Ramos, M., 2010, In: European Journal of Neuroscience. 32, 3, p. 409-22 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
Sanchez-Guajardo, V., Febbraro, F., Kirik, D. & Romero-Ramos, M., 2010, In: P L o S One. 5, 1, p. e8784Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
File227 Downloads (Pure) -
2009
Distribution of Na/K-ATPase alpha3-isoform, a sodium-potassium P-type pump associated with Rapid Onset of Dystonia Parkinson (RDP), in the adult mouse brain
Bøttger, P., Tracz, Z., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K., 2009.Research output: Contribution to conference › Poster › Research
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Distribution of the Na/K-ATPase alpha2-isoform, a sodium-potassium P-type pump constituent associated with Familial Hemiplegic Migraine type 2 (FHM2), in the adult mouse brain.
Bøttger, P., Pelc, M., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K., 2009. 1 p.Research output: Contribution to conference › Poster › Communication
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Suppression of MAP kinases inhibits microglial activation and attenuates neuronal cell death induced by alpha-synuclein protofibrils
Wilms, H., Rosenstiel, P., Romero-Ramos, M., Arlt, A., Schäfer, H., Seegert, D., Odoy, S., Claasen, J., Holzknecht, C., Brandenburg, L., Deuschl, G., Schreiber, S., Kirik, D. & Lucius, R., 2009, In: International Journal of Immunopathology and Pharmacology. 22, 4, p. 897-909Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2008
Transgenic mouse models for two inherited neuronal diseases
Bøttger, P., Tracz, Z., Pelc, M., Albertsen, M., Strandbygård, D. J., Romero-Ramos, M. & Lykke-Andersen, K., 2008.Research output: Contribution to conference › Poster › Research
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2007
Long-term overexpression of alpha-synuclein in primates ventral midbrain leads to motor behavioral deficits
Eslamboli, A., Romero-Ramos, M., Burger, C., Bjorklund, T., Muzyczka, N., Mandel, R. J., Baker, H., Ridley, R. M. & Kirik, D., 2007, In: Brain. 130, 3, p. 799-815Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review