Martin Roelsgaard Jakobsen

2024

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

Zhang, B.-C., Laursen, M. F., Hu, L., Hazrati, H., Narita, R., Jensen, L. S., Hansen, A. S., Huang, J., Zhang, Y., Ding, X., Muyesier, M., Nilsson, E., Banasik, A., Zeiler, C., Mogensen, T. H., Etzerodt, A., Agger, R., Johannsen, M., Kofod-Olsen, E. & Paludan, S. R. & 1 others, Jakobsen, M. R., Dec 2024, In: Nature Communications. 15, 1, 2760.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

6 Citations (Scopus)

The balance of STING signaling orchestrates immunity in cancer

Lanng, K. R. B., Lauridsen, E. L. & Jakobsen, M. R., Jul 2024, In: Nature Immunology. 25, 7, p. 1144-1157 14 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

12 Citations (Scopus)

2023

Analysis of circulating tumor DNA during checkpoint inhibition in metastatic melanoma using a tumor-agnostic panel

Kisistók, J., Christensen, D. S., Rasmussen, M. H., Duval, L., Aggerholm-Pedersen, N., Luczak, A. A., Sorensen, B. S., Jakobsen, M. R., Oellegaard, T. H. & Birkbak, N. J., Oct 2023, In: Melanoma Research. 33, 5, p. 364-374 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

1 Citation (Scopus)

5 Downloads (Pure)

Single cell analysis reveals a subset of cytotoxic-like plasmacytoid dendritic cells in people with HIV-1

Cham, L. B., Gunst, J. D., Schleimann, M. H., Frattari, G. S., Rosas-Umbert, M., Vibholm, L. K., van der Sluis, R. M., Jakobsen, M. R., Olesen, R., Lin, L., Tolstrup, M. & Søgaard, O. S., Sept 2023, In: iScience. 26, 9, 15 p., 107628.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

4 Citations (Scopus)

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

Hansen, A. S., Jensen, L. S., Gammelgaard, K. R., Ryttersgaard, K. G., Krapp, C., Just, J., Jønsson, K. L., Jensen, P. B., Boesen, T., Johannsen, M., Etzerodt, A., Deleuran, B. W. & Jakobsen, M. R., Aug 2023, In: Journal of Extracellular Vesicles. 12, 8, 17 p., 12350.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

5 Citations (Scopus)

2022

Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer

Sokac, M., Ahrenfeldt, J., Litchfield, K., Watkins, T. B. K., Knudsen, M., Dyrskjøt, L., Jakobsen, M. R. & Birkbak, N. J., Aug 2022, In: Cancer Research Communications. 2, 8, p. 762-771 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

8 Citations (Scopus)

IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection

Griffante, G., Hewelt-Belka, W., Albano, C., Gugliesi, F., Pasquero, S., Castillo Pacheco, S. F., Bajetto, G., Porporato, P. E., Mina, E., Vallino, M., Krapp, C., Jakobsen, M. R., Purdy, J., von Einem, J., Landolfo, S., Dell'Oste, V. & Biolatti, M., Jun 2022, In: mBio. 13, 3, p. e0043522 19 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

3 Citations (Scopus)

Increased Soluble PD-1 Predicts Response to Nivolumab plus Ipilimumab in Melanoma

Pedersen, J. G., Sokac, M., Sørensen, B. S., Luczak, A. A., Aggerholm-Pedersen, N., Birkbak, N. J., Øllegaard, T. H. & Jakobsen, M. R., Jul 2022, In: Cancers. 14, 14, 3342.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

17 Citations (Scopus)

Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy

Hernández, S. S., Jakobsen, M. R. & Bak, R. O., Sept 2022, In: International Journal of Molecular Sciences . 23, 19, 11397.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

20 Citations (Scopus)

Plasmacytoid dendritic cells during COVID-19: Ally or adversary?

van der Sluis, R. M., Holm, C. K. & Jakobsen, M. R., 26 Jul 2022, In: Cell Reports. 40, 4, 111148.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

18 Citations (Scopus)

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection

van der Sluis, R. M., Cham, L. B., Gris-Oliver, A., Gammelgaard, K. R., Pedersen, J. G., Idorn, M., Ahmadov, U., Hernandez, S. S., Cémalovic, E., Godsk, S. H., Thyrsted, J., Gunst, J. D., Nielsen, S. D., Jørgensen, J. J., Bjerg, T. W., Laustsen, A., Reinert, L. S., Olagnier, D., Bak, R. O. & Kjolby, M. & 6 others, Holm, C. K., Tolstrup, M., Paludan, S. R., Kristensen, L. S., Søgaard, O. S. & Jakobsen, M. R., May 2022, In: EMBO Journal. 41, 10, 19 p., e109622.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

56 Citations (Scopus)

45 Downloads (Pure)

2021

Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern

Carter-Timofte, M. E., Arulanandam, R., Kurmasheva, N., Fu, K., Laroche, G., Taha, Z., Van Der Horst, D., Cassin, L., Van Der Sluis, R. M., Palermo, E., Di Carlo, D., Jacobs, D., Maznyi, G., Azad, T., Singaravelu, R., Ren, F., Hansen, A. L., Idorn, M., Holm, C. K. & Jakobsen, M. R. & 10 others, Van Grevenynghe, J., Hiscott, J., Paludan, S. R., Bell, J. C., Seguin, J., Sabourin, L. A., Côté, M., Diallo, J. S., Alain, T. & Olagnier, D., 12 Nov 2021, In: ACS Infectious Diseases. 7, 11, p. 3034-3051 18 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

18 Citations (Scopus)

Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

Laustsen, A., van der Sluis, R. M., Gris Oliver, A., Sanchez Hernandez, S., Cemalovic, E., Tang, H. Q., Pedersen, L. H., Uldbjerg, N., Jakobsen, M. R. & Bak, R., Sept 2021, In: eLife. 10, 21 p., e65528.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

7 Citations (Scopus)

Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status

Pedersen, J. G., Egedal, J. H., Packard, T. A., Thavachelvam, K., Xie, G., van der Sluis, R. M., Greene, W. C., Roan, N. R. & Jakobsen, M. R., 26 Nov 2021, In: Frontiers in Microbiology. 12, 11 p., 763030.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

cGAS-STING pathway expression as a prognostic tool in NSCLC

Raaby Gammelgaard, K., Sandfeld-Paulsen, B., Godsk, S. H., Demuth, C., Meldgaard, P., Sorensen, B. S. & Jakobsen, M. R., Jan 2021, In: Translational Lung Cancer Research. 10, 1, p. 340-354 15 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

19 Citations (Scopus)

67 Downloads (Pure)

Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection

Egedal, J. H., Xie, G., Packard, T. A., Laustsen, A., Neidleman, J., Georgiou, K., Pillai, S. K., Greene, W. C., Jakobsen, M. R. & Roan, N. R., Sept 2021, In: Mucosal Immunology. 14, 5, p. 1203-1213 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

9 Citations (Scopus)

44 Downloads (Pure)

Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS-STING Pathway

Liu, H., Ottosen, R. N., Jennet, K. M., Svenningsen, E. B., Kristensen, T. F., Biltoft, M., Jakobsen, M. R. & Poulsen, T. B., Aug 2021, In: Angewandte Chemie International Edition. 60, 34, p. 18734-18741 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

7 Citations (Scopus)

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis

Køster, D., Egedal, J. H., Lomholt, S., Hvid, M., Jakobsen, M. R., Müller-Ladner, U., Eibel, H., Deleuran, B., Kragstrup, T. W., Neumann, E. & Nielsen, M. A., Dec 2021, In: Scientific Reports. 11, 1, 22168.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

15 Citations (Scopus)

2020

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Olagnier, D., Farahani, E., Thyrsted, J., Blay-Cadanet, J., Herengt, A., Idorn, M., Hait, A., Hernaez, B., Knudsen, A., Iversen, M. B., Schilling, M., Jørgensen, S. E., Thomsen, M., Reinert, L. S., Lappe, M., Hoang, H.-D., Gilchrist, V. H., Hansen, A. L., Ottosen, R. & Nielsen, C. G. & 18 others, Møller, C., van der Horst, D., Peri, S., Balachandran, S., Huang, J., Jakobsen, M., Svenningsen, E. B., Poulsen, T. B., Bartsch, L., Thielke, A. L., Luo, Y., Alain, T., Rehwinkel, J., Alcamí, A., Hiscott, J., Mogensen, T. H., Paludan, S. R. & Holm, C. K., 21 Oct 2020, In: Nature Communications. 11, 1, 1 p., 5419.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

Open Access

10 Citations (Scopus)

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Van der Sluis, R. M., Zerbato, J. M., Rhodes, J. W., Pascoe, R. D., Solomon, A., Kumar, N. A., Dantanarayana, A. I., Tennakoon, S., Dufloo, J., McMahon, J., Chang, J. J., Evans, V. A., Hertzog, P. J., Jakobsen, M. R., Harman, A. N., Lewin, S. R. & Cameron, P. U., 2020, In: PLOS Pathogens. 16, 2, 27 p., e1008151.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

35 Citations (Scopus)

Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors

Pedersen, J. G., Madsen, A. T., Gammelgaard, K. R., Aggerholm-Pedersen, N., Sørensen, B. S., Øllegaard, T. H. & Jakobsen, M. R., Jun 2020, In: Cancers. 12, 6, p. 1-15 15 p., 1414.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

17 Citations (Scopus)

Phenotypic and Functional Characterisation of Synovial Fluid-derived Fibroblast-like Synoviocytes in Rheumatoid Arthritis

Koster, D., Egedal, J. H., Hvid, M., Jakobsen, M. R., Mueller-Ladner, U., Deleuran, B., Kragstrup, T. W., Neumann, E. & Nielsen, M. A., 2020, ARTHRITIS RHEUMATOLOGY. Vol. 72.

Research output: Contribution to book/anthology/report/proceeding › Article in proceedings › Research › peer-review

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis

Køster, D., Egedal, J. H., Hvid, M., Jakobsen, M. R., Mueller-Ladner, U., Deleuran, B., Kragstrup, T. W., Neumann, E. & Nielsen, M. A., 2020, In: Annals of the Rheumatic Diseases. 79, Suppl.1, p. 1345 1 p., AB0100.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review

Plasmacytoid Dendritic Cells as Cell-Based Therapeutics: A Novel Immunotherapy to Treat Human Immunodeficiency Virus Infection?

van der Sluis, R. M., Egedal, J. H. & Jakobsen, M. R., 26 May 2020, In: Frontiers in cellular and infection microbiology. 10, 12 p., 249.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

13 Citations (Scopus)

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Olagnier, D., Farahani, E., Thyrsted, J., Blay-Cadanet, J., Herengt, A., Idorn, M., Hait, A., Hernaez, B., Knudsen, A., Iversen, M. B., Schilling, M., Jørgensen, S. E., Thomsen, M., Reinert, L. S., Lappe, M., Hoang, H.-D., Gilchrist, V. H., Hansen, A. L., Ottosen, R. & Nielsen, C. G. & 18 others, Møller, C., van der Horst, D., Peri, S., Balachandran, S., Huang, J., Jakobsen, M., Svenningsen, E. B., Poulsen, T. B., Bartsch, L., Thielke, A. L., Luo, Y., Alain, T., Rehwinkel, J., Alcamí, A., Hiscott, J., Mogensen, T. H., Paludan, S. R. & Holm, C. K., 1 Dec 2020, In: Nature Communications. 11, 1, 12 p., 4938.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

299 Citations (Scopus)

Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling

George, A. F., Jang, K. S., Nyegaard, M., Neidleman, J., Spitzer, T. L., Xie, G., Chen, J. C., Herzig, E., Laustsen, A., Marques de Menezes, E. G., Houshdaran, S., Pilcher, C. D., Norris, P. J., Jakobsen, M. R., Greene, W. C., Giudice, L. C. & Roan, N. R., 2020, In: Human Reproduction. 35, 3, p. 617-640 24 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

28 Citations (Scopus)

2019

cAIMP administration in humanized mice induces a chimerization-level-dependent STING response

Andersen, A. H. F., Olesen, R., Jønsson, K. L., Højen, J. F., Krapp, C., Mack, K., Thomsen, M. K., Østergaard, L., Tolstrup, M., Dagnæs-Hansen, F., Jakobsen, M. R. & Denton, P. W., 2019, In: Immunology. 157, 2, p. 163-172 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

8 Citations (Scopus)

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids

Sun, C., Luecke, S., Bodda, C., Jønsson, K. L., Cai, Y., Zhang, B. C., Jensen, S. B., Nordentoft, I., Jensen, J. M., Jakobsen, M. R. & Paludan, S. R., 2019, In: Journal of Interferon and Cytokine Research. 39, 4, p. 191-204 14 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

20 Citations (Scopus)

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Braun, E., Hotter, D., Koepke, L., Zech, F., Groß, R., Sparrer, K. M. J., Müller, J. A., Pfaller, C. K., Heusinger, E., Wombacher, R., Sutter, K., Dittmer, U., Winkler, M., Simmons, G., Jakobsen, M. R., Conzelmann, K.-K., Pöhlmann, S., Münch, J., Fackler, O. T. & Kirchhoff, F. & 1 others, Sauter, D., 14 May 2019, In: Cell Reports. 27, 7, p. 2092-2104.e10 23 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

109 Citations (Scopus)

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination

Martin, R. M., Ikeda, K., Cromer, M. K., Uchida, N., Nishimura, T., Romano, R., Tong, A. J., Lemgart, V. T., Camarena, J., Pavel-Dinu, M., Sindhu, C., Wiebking, V., Vaidyanathan, S., Dever, D. P., Bak, R. O., Laustsen, A., Lesch, B. J., Jakobsen, M. R., Sebastiano, V. & Nakauchi, H. & 1 others, Porteus, M. H., 2 May 2019, In: Cell Stem Cell. 24, 5, p. 821-828.e5 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

137 Citations (Scopus)

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

Hotter, D., Bosso, M., Jønsson, K. L., Krapp, C., Stürzel, C. M., Das, A., Littwitz-Salomon, E., Berkhout, B., Russ, A., Wittmann, S., Gramberg, T., Zheng, Y., Martins, L. J., Planelles, V., Jakobsen, M. R., Hahn, B. H., Dittmer, U., Sauter, D. & Kirchhoff, F., Jun 2019, In: Cell Host & Microbe. 25, 6, p. 858-872.e13 29 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

90 Citations (Scopus)

2018

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

Prabakaran, T., Bodda, C., Krapp, C., Zhang, B.-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R. & Gyrd-Hansen, M. & 1 others, Paludan, S. R., 13 Apr 2018, In: E M B O Journal. 37, 8, E97858.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

313 Citations (Scopus)

CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS- and STING-dependent Maturation

Laursen, M. F., Christensen, E., Degn, L. L. T., Jønsson, K., Jakobsen, M. R., Agger, R. & Kofod-Olsen, E., Jan 2018, In: Journal of Immunotherapy. 41, 1, p. 9-18 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

ERAdP standing in the shadow of STING innate immune signaling

Jakobsen, M. R., 1 Feb 2018, In: Nature Immunology. 19, 19, p. 105-107 3 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

3 Citations (Scopus)

Human cytomegalovirus tegument protein pp65 (pUL83) dampens type I interferon production by inactivating the DNA sensor cGAS without affecting STING

Biolatti, M., Dell'Oste, V., Pautasso, S., Gugliesi, F., von Einem, J., Krapp, C., Jakobsen, M. R., Borgogna, C., Gariglio, M., De Andrea, M. & Landolfo, S., Mar 2018, In: Journal of Virology. 92, 6, 18 p., e01774-17.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

95 Citations (Scopus)

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Laustsen, A., Bak, R., Krapp, C., Kjær, L., Egedahl, J. H., Petersen, C. C., Pillai, S., Tang, H. Q., Uldbjerg, N., Porteus, M., Roan, N. R., Nyegaard, M., Denton, P. W. & Jakobsen, M. R., 30 Aug 2018, In: Nature Communications. 9, 1, 14 p., 3525.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

32 Citations (Scopus)

Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors

Nissen, S. K., Pedersen, J. G., Helleberg, M., Kjaer, K., Thavachelvam, K., Obel, N., Tolstrup, M., Jakobsen, M. R. & Mogensen, T. H., 15 May 2018, In: Journal of Immunology. 200, 10, p. 3372-3382 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Hansen, A. L., Buchan, G. J., Rühl, M., Mukai, K., Salvatore, S. R., Ogawa, E., Andersen, S. D., Iversen, M. B., Thielke, A. L., Gunderstofte, C., Motwani, M., Møller, C. T., Jakobsen, A. S., Fitzgerald, K. A., Roos, J., Lin, R., Maier, T. J., Goldbach-Mansky, R., Miner, C. A. & Qian, W. & 9 others, Miner, J. J., Rigby, R. E., Rehwinkel, J., Jakobsen, M. R., Arai, H., Taguchi, T., Schopfer, F. J., Olagnier, D. & Holm, C. K., 14 Aug 2018, In: Proceedings of the National Academy of Sciences (PNAS). 115, 33, p. E7768-E7775 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

184 Citations (Scopus)

124 Downloads (Pure)

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Dunphy, G., Flannery, S. M., Almine, J. F., Connolly, D. J., Paulus, C., Jønsson, K. L., Jakobsen, M. R., Nevels, M. M., Bowie, A. G. & Unterholzner, L., 6 Sept 2018, In: Molecular Cell. 71, 5, p. 745-760.e5

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

440 Citations (Scopus)

533 Downloads (Pure)

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Olagnier, D., Brandtoft, A. M., Gunderstofte, C., Villadsen, N. L., Krapp, C., Thielke, A. L., Laustsen, A., Peri, S., Hansen, A. L., Bonefeld, L., Thyrsted, J., Bruun, V., Iversen, M. B., Lin, L., Artegoitia, V. M., Su, C., Yang, L., Lin, R., Balachandran, S. & Luo, Y. & 14 others, Nyegaard, M., Marrero, B., Goldbach-Mansky, R., Motwani, M., Ryan, D. G., Fitzgerald, K. A., O'Neill, L. A., Hollensen, A. K., Damgaard, C. K., de Paoli, F. V., Bertram, H. C., Jakobsen, M. R., Poulsen, T. B. & Holm, C. K., 1 Dec 2018, In: Nature Communications. 9, 1, 13 p., 3506.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

197 Citations (Scopus)

STING dependent sensing - Does HIV actually care?

Krapp, C., Jønsson, K. & Jakobsen, M. R., Apr 2018, In: Cytokine & Growth Factor Reviews. 40, p. 68-76 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

11 Citations (Scopus)

STING regulation in lung cancer

Gammelgaard, K. R., Paulsen, B. S., Demuth, C., Pedersen, J. G., Meldgaard, P., Sørensen, B. S. & Jakobsen, M. R., 2018.

Research output: Contribution to conference › Poster › Research

The Impact of genetic Variants of STING and IFI16 on Non-Small Cell Lung Cancer

Gammelgaard, K. R., Paulsen, B. S., Demuth, C., Pedersen, J. G., Nyegaard, M., Meldgaard, P., Sørensen, B. S. & Jakobsen, M. R., 2018.

Research output: Contribution to conference › Poster › Research › peer-review

Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules

Nissen, S. K., Christiansen, M., Helleberg, M., Kjær, K., Jørgensen, S. E., Gerstoft, J., Katzenstein, T. L., Benfield, T., Kronborg, G., Larsen, C. S., Laursen, A., Pedersen, G., Jakobsen, M. R., Tolstrup, M. & Mogensen, T. H., 1 Dec 2018, In: Scientific Reports. 8, 1, p. 15253 15253.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

14 Citations (Scopus)

2017

cGAS is activated by DNA in a length-dependent manner

Luecke, S., Holleufer, A., Christensen, M. H., Jønsson, K. L., Boni, G. A., Sørensen, L. K., Johannsen, M., Jakobsen, M. R., Hartmann, R. & Paludan, S. R., Oct 2017, In: E M B O Reports. 18, 10, p. 1707–1715 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

221 Citations (Scopus)

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjolby, M., Mohammadi, P., Prabakaran, T., Sørensen, L. K., Sun, C., Jensen, S. B., Holm, C. K., Lebbink, R. J., Johannsen, M., Nyegaard, M., Mikkelsen, J. G., Kirchhoff, F. & Paludan, S. R. & 1 others, Jakobsen, M. R., 10 Feb 2017, In: Nature Communications. 8, 14391.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

231 Citations (Scopus)

Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells

Neidleman, J. A., Chen, J. C., Kohgadai, N., Müller, J. A., Laustsen, A., Thavachelvam, K., Jang, K. S., Stürzel, C. M., Jones, J., Ochsenbauer, C., Chitre, A., Somsouk, M., Garcia, M. M., Smith, J. F., Greenblatt, R. M., Münch, J., Jakobsen, M. R., Giudice, L. C., Greene, W. C. & Roan, N. R., Feb 2017, In: P L o S Pathogens. 13, 2, p. e1006163 e1006163.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

53 Citations (Scopus)

2016

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Borm, K., Jakobsen, M. R., Cashin, K., Flynn, J. K., Ellenberg, P., Østergaard, L., Lee, B., Churchill, M. J., Roche, M. & Gorry, P. R., 3 Nov 2016, In: Retrovirology. 13, 1, 13 p., 74.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

4 Citations (Scopus)

Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract

Roan, N. R. & Jakobsen, M. R., 1 Feb 2016, In: Current HIV - AIDS Reports. 13, 1, p. 53-63 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

3 Citations (Scopus)

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Holm, C. K., Rahbek, S. H., Gad, H. H., Bak, R. O., Jakobsen, M. R., Jiang, Z., Hansen, A. L., Jensen, S. K., Sun, C., Thomsen, M. K., Laustsen, A., Nielsen, C. G., Severinsen, K., Xiong, Y., Burdette, D. L., Hornung, V., Lebbink, R. J., Duch, M., Fitzgerald, K. A. & Bahrami, S. & 3 others, Mikkelsen, J. G., Hartmann, R. & Paludan, S. R., 19 Feb 2016, In: Nature Communications. 7, 10680.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

174 Citations (Scopus)

Martin Roelsgaard Jakobsen

Research output

Search results