Morten Ladekarl


Morten Ladekarl


  • Department of Clinical Medicine - The Department of Oncology
  • The Department of Oncology
Postal address:
Nørrebrogade 44
Aarhus C
Postal address:
Århus Sygehus;Nørrebrogade 44
Århus C


Mobile: 61399326

Phone: 89492654, 78462654

Year of birth



2002Specialist in oncology, Aarhus University Hospital and Aalblerg University Hospital, Denmark
1989MD, Faculty of Health, University of Aarhus, Denmark

Academic degrees


Research areas

Quantitative assessments of cancer structures in tissue, including inflammation
Cancer immunologi
Cancer and prognosis
Experimental cancer treatment
Clinical trials in patients with upper gastrointestinal tumours, hepatocellular carcinoma, neuroendocrine tumours and cancers with unknown primary
Rare cancers

Present postion

2013-Consultant oncologist, Department of Oncology, Aarhus University Hospital, Denmark

Previous positions

2007Associate professor at University of Aarhus, Denmark
2005Consultant at Department of Oncology, Aarhus University Hospital, Denmark
2003-2005Senior medical officer at Dept. of Oncology, Aarhus University Hospital.
1996-2003Recident at Dept. of Oncology, Aarhus University Hospital and Department of Oncology, Aalborg University Hospital, Denmark
1995-1996Recident at Department of Pathology, Regionshospitalet Randers, Denmark
1991-1995Recearch fellow at Stereological Research Laboratory, Danish Cancer Society, Aarhus University Hospital, Denmark
1989-1991Recident, several clinical departments, Regionshospitalet Randers, Aarhus University Hospital and Regionshospitalet Vest, Denmark

Publications and presentations

Publications: 36, Peer-reviewed articles: 35, H-index: 8, Citations: 302, Scientific meeting presentations (oral): ?

Board memberships

Member of the National Board of Health committee for experimental cancer treatment
Member of three Danish Multidiciplinary Groups for, respectively, pancreatic cancer, liver tumours and gastro-esophageal tumors
Past president and current secretary for Scandinavian Network for Hepatocellular Carcinoma
Member of the National Board of Health committee (RADS) for treatment of neuroendocrine tumors
Member of the National Board of Health committee for follow-up of patients with upper gastro-intestinal tumors
Member of the Nordic Network for Neuroendocrine Tumors


Supervisor for 3 PhD. students
2 completed and 1 ongoing

Awards and grants

Danish Cancer Society
Thaysen Foundation
Colind Foundation
Foersom Foundation
King Christian X Foundation
Fonden til lægevidenskabens fremme
Novo Foundation
Yde Foundation
Schølin Foundation
Kopp Foundation
Danielsen Foundation

Organizer of meetings

2 annual meetings in Scandinavian Network for Hepatocellular Carcinoma
3 annual meetings in Sector for Clinical Research at the Department of Oncology, Aarhus

Scientific journal involvements

>44 oral and poster presentations at national and international meetings
38 scientific articles


ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling – a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial

Kringelbach, T., Højgaard, M., Rohrberg, K., Spanggaard, I., Laursen, B. E., Ladekarl, M., Haslund, C. A., Harsløf, L., Belcaid, L., Gehl, J., Søndergaard, L., Eefsen, R. L., Hansen, K. H., Kodahl, A. R., Jensen, L. H., Holt, M. I., Oellegaard, T. H., Yde, C. W., Ahlborn, L. B. & Lassen, U., Dec 2023, In: BMC Cancer. 23, 1, 182.

Disparity in use of modern combination chemotherapy associated with facility type influences survival of 2655 patients with advanced pancreatic cancer

Ladekarl, M., Rasmussen, L. S., Kirkegård, J., Chen, I., Pfeiffer, P., Weber, B., Skuladottir, H., Østerlind, K., Larsen, J. S., Mortensen, F. V., Engberg, H., Møller, H. & Fristrup, C. W., Mar 2022, In: Acta Oncologica. 61, 3, p. 277-285 9 p.

Prognostic significance of T-cell-inflamed gene expression profile and PD-L1 expression in patients with esophageal cancer

Steiniche, T., Rha, S. Y., Chung, H. C., Georgsen, J. B., Ladekarl, M., Nordsmark, M., Jespersen, M. L., Kim, H. S., Kim, H., Fein, C., Tang, L. H., Wu, T., Marton, M. J., Peter, S., Kelsen, D. P. & Ku, G., Dec 2021, In: Cancer Medicine. 10, 23, p. 8365-8376 12 p.

Nationwide survival benefit after implementation of first-line immunotherapy for patients with advanced nsclc—real world efficacy

Mouritzen, M. T., Carus, A., Ladekarl, M., Meldgaard, P., Nielsen, A. W. M., Livbjerg, A., Larsen, J. W., Skuladottir, H., Kristiansen, C., Wedervang, K., Schytte, T., Hansen, K. H., Østby, A. C., Frank, M. S., Lauritsen, J., Sørensen, J. B., Langer, S. W., Persson, G. F., Andersen, J. L., Frary, J. M. C., Drivsholm, L. B., Vesteghem, C., Christensen, H. S., Bjørnhart, B. & Pøhl, M., Oct 2021, In: Cancers. 13, 19, 13 p., 4846.

Clinically decisive (dis)agreement in multidisciplinary team assessment of esophageal squamous cell carcinoma; a prospective, national, multicenter study

Achiam, M. P., Nordsmark, M., Ladekarl, M., Olsen, A., Loft, A., Garbyal, R. S., Larsen, M. H., Ainsworth, A. P., Kristensen, T. S., Dikinis, S., Kjær, D. W., Bæksgaard, L., Siemsen, M., Nielsen, M. B., Schlander, S., Kramer, S., Katballe, N., Kruhlikava, I., Tabaksblat, E., Fisker, R. V., Mortensen, P. B., Holtved, E., Eckardt, J., Detlefsen, S., Naujokaite, G. & Lütken, C. D., Sept 2021, In: Acta Oncologica. 60, 9, p. 1091-1099 9 p.


Naseri, S., Steiniche, T., Ladekarl, M., Hölmich, L. R., Langer, S. W., Tabaksblat, E., Junker, N. & Chakera, A. H., Jul 2021, In: Ugeskrift for Læger. 183, 30, 9 p., V03210260.

Patterns of Palliative Chemotherapy and Survival in Patients with Pancreatic Cancer Focusing on Age: A Nationwide Real-World Danish Registry Study

Rasmussen, L. S., Fristrup, C. W., Jensen, B. V., Pfeiffer, P., Weber, B., Yilmaz, M. K., Poulsen, L., Ladekarl, M., Østerlind, K., Larsen, J. S., Skuladottir, H., Bøgsted, M. & Falkmer, U. G., May 2021, In: Pancreas. 50, 5, p. 685-695 11 p.

Surgery of the primary tumour in 201 patients with high-grade gastroenteropancreatic neuroendocrine and mixed neuroendocrine-non-neuroendocrine neoplasms

Pommergaard, H. C., Nielsen, K., Sorbye, H., Federspiel, B., Tabaksblat, E. M., Vestermark, L. W., Janson, E. T., Hansen, C. P., Ladekarl, M., Garresori, H., Hjortland, G. O., Sundlöv, A., Galleberg, R., Knigge, P., Kjaer, A., Langer, S. W. & Knigge, U., May 2021, In: Journal of Neuroendocrinology. 33, 5, 12 p., e12967.

PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3

Ali, A. S., Langer, S. W., Federspiel, B., Hjortland, G. O., Grønbæk, H., Ladekarl, M., Welin, S., Weber Vestermark, L., Arola, J., Osterlund, P., Knigge, U., Sørbye, H., Micke, P., Grimelius, L., Grönberg, M. & Tiensuu Janson, E., Dec 2020, In: PLOS ONE. 15, 12, 12 p., e0243900.

International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis

Díaz-González, Á., Sanduzzi-Zamparelli, M., da Fonseca, L. G., Di Costanzo, G. G., Alves, R., Iavarone, M., Leal, C., Sacco, R., Matilla, A. M., Hernández-Guerra, M., Aballay Soteras, G., Wörns, M. A., Pinter, M., Varela, M., Ladekarl, M., Chagas, A. L., Mínguez, B., Arenas, J. I., Granito, A., Sánchez-Torrijos, Y., Rojas, Á., Rodríguez de Lope, C., Alvares-da-Silva, M. R., Pascual, S., Rimassa, L., Lledó, J. L., Huertas, C., Sangro, B., Giannini, E. G., Delgado, M., Vergara, M., Perelló, C., Lue, A., Sala, M., Gallego, A., Coll, S., Hernáez, T., Piñero, F., Pereira, G., França, A., Marín, J., Anders, M., Mello, V., Lozano, M., Nault, J. C., Menéndez, J., García Juárez, I., Bruix, J. & Reig, M., Jun 2020, In: Liver International. 40, 6, p. 1467-1476 10 p.

Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis

Kirkegård, J., Gaber, C., Lund, J. L., Hinton, S. P., Ladekarl, M., Heide-Jørgensen, U., Cronin-Fenton, D. & Mortensen, F. V., Feb 2020, In: Cancer epidemiology. 64, 9 p., 101647.

Initial treatment and survival in 4163 Danish patients with pancreatic cancer: A nationwide unselected real-world register study

Rasmussen, L. S., Fristrup, C. W., Jensen, B. V., Pfeiffer, P., Weber, B., Yilmaz, M. K., Poulsen, L. Ø., Ladekarl, M., Østerlind, K., Larsen, J. S., Skuladottir, H., Hansen, C. P., Mortensen, M. B., Mortensen, F. V., Sall, M., Detlefsen, S., Bøgsted, M. & Falkmer, U. G., 2020, In: European Journal of Cancer. 129, p. 50-59 10 p.

Tumor ulceration, reduced infiltration of CD8-lymphocytes, high neutrophil-to-CD8-lymphocyte ratio and absence of MC virus are negative prognostic markers for patients with merkel cell carcinoma

Naseri, S., Steiniche, T., Georgsen, J. B., Thomsen, R., Ladekarl, M., Heje, M., Damsgaard, T. E. & Bønnelykke-Behrndtz, M. L., 2020, In: Cancers. 12, 4, 11 p., 888.

The effect of postoperative gemcitabine on overall survival in patients with resected pancreatic cancer: A nationwide population-based Danish register study

Skau Rasmussen, L., Vittrup, B., Ladekarl, M., Pfeiffer, P., Karen Yilmaz, M., Østergaard Poulsen, L., Østerlind, K., Palnæs Hansen, C., Bau Mortensen, M., Viborg Mortensen, F., Sall, M., Detlefsen, S., Bøgsted, M. & Wilki Fristrup, C., Jun 2019, In: Acta Oncologica. 58, 6, p. 864-871 8 p.

Carcinoma of Unknown Primary Site (CUP) With Metastatic Renal-Cell Carcinoma (mRCC) Histologic and Immunohistochemical Characteristics (CUP-mRCC): Results From Consecutive Patients Treated With Targeted Therapy and Review of Literature

Overby, A., Duval, L., Ladekarl, M., Laursen, B. E. & Donskov, F., Feb 2019, In: Clinical Genitourinary Cancer. 17, 1, p. e32-e37 6 p.

Urban versus Rural Residency and Pancreatic Cancer Survival: A Danish Nationwide Population-based Cohort Study

Kirkegård, J., Ladekarl, M., Fristrup, C. W., Hansen, C. P., Sall, M. & Mortensen, F. V., 16 Aug 2018, In: PLOS ONE. 13, 8

Intravenous versus oral etoposide: efficacy and correlation to clinical outcome in patients with high-grade metastatic gastroenteropancreatic neuroendocrine neoplasms (WHO G3)

Ali, A. S., Grönberg, M., Langer, S. W., Ladekarl, M., Hjortland, G. O., Vestermark, L. W., Österlund, P., Welin, S., Grønbæk, H., Knigge, U., Sorbye, H. & Janson, E. T., 6 Mar 2018, In: Medical Oncology. 35, 4, p. 47

Effects of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Goblet Cell Carcinoma: A Prospective Cohort Study

Madsen, A. H., Ladekarl, M., Villadsen, G. E., Grønbæk, H., Sørensen, M. M., Stribolt, K., Verwaal, V. J. & Iversen, L. H., Feb 2018, In: Annals of Surgical Oncology. 25, 2, p. 422-430 9 p.

Association of PD-L1 expression with prognosis among patients with 10 select cancers

Steiniche, T., Ladekarl, M., Bæhr Georgsen, J., Andreasen, S., Busch-Sørensen, M., Zhou, W., Pruitt, S. K., Joe, A. K. & Liaw, K-L., 2018, In: Annals of Oncology. 29, p. viii15

Results after surgical treatment of liver metastases in patients with high-grade gastroenteropancreatic neuroendocrine carcinomas

Galleberg, R. B., Knigge, U., Tiensuu Janson, E., Vestermark, L. W., Haugvik, S-P., Ladekarl, M., Langer, S. W., Grønbæk, H., Österlund, P., Hjortland, G. O., Assmus, J., Tang, L., Perren, A. & Sorbye, H., Sept 2017, In: European Journal of Surgical Oncology. 43, 9, p. 1682-1689 8 p.

Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma

Ali, A. S., Grönberg, M., Federspiel, B., Scoazec, J-Y., Hjortland, G. O., Grønbæk, H., Ladekarl, M., Langer, S. W., Welin, S., Vestermark, L. W., Arola, J., Österlund, P., Knigge, U., Sorbye, H., Grimelius, L. & Janson, E. T., 2017, In: P L o S One. 12, 11, 15 p., e0187667.

BRCA-associated pancreatico-biliary neoplasms: Four cases illustrating the emerging clinical impact of genotyping

Sharma, M. B., Carus, A., Sunde, L., Hamilton-Dutoit, S. & Ladekarl, M., 2016, In: Acta Oncologica. p. 1-5 5 p.

A Nationwide Retrospective Study of Perioperative Chemotherapy for Gastroesophageal Adenocarcinoma: Tolerability, Outcome, and Prognostic Factors

Larsen, A. C., Holländer, C., Duval, L., Schønnemann, K., Achiam, M., Pfeiffer, P., Yilmaz, M. K., Thorlacius-Ussing, O., Bæksgaard, L. & Ladekarl, M., May 2015, In: Annals of Surgical Oncology. 22, 5, p. 1540-1547 8 p.

Goblet cell carcinoids: characteristics of a Danish cohort of 83 patients

Olsen, I. H., Holt, N., Langer, S. W., Hasselby, J. P., Grønbæk, H., Hillingsø, J., Mahmoud, M., Ladekarl, M., Iversen, L. H., Kjær, A., Federspiel, B. H. & Knigge, U., 2015, In: PLOS ONE. 10, 2, p. e0117627

Postoperative but not preoperative treatment with sorafenib inhibits liver regeneration in rats

Andersen, K. J., Knudsen, A. R., Kannerup, A-S., Nyengaard, J. R., Hamilton-Dutoit, S., Ladekarl, M. & Mortensen, F. V., 15 Apr 2014, In: The Journal of surgical research.

Danish experiences with FOLFIRINOX as first-line therapy in patients with inoperable pancreatic cancer

Kræmer, P. C., Schmidt, H. H. & Ladekarl, M., Apr 2014, In: Danish Medical Journal. 61, 4, 4 p., A4819.

Strong Prognostic Value of Tumor-infiltrating Neutrophils and Lymphocytes Assessed by Automated Digital Image Analysis in Early Stage Cervical Cancer: A Comparator Study with Observer-assisted Stereological Assessments

Carus, A., Donskov, F., Nielsen, P. S., Hager, H., Nedergaard, B., Steiniche, T. & Ladekarl, M., 2014, In: Journal of OncoPathology. 2, 2, p. 1-9 9 p.

Impact of baseline and nadir neutrophil index in non-small cell lung cancer and ovarian cancer patients: Assessment of chemotherapy for resolution of unfavourable neutrophilia

Carus, A., Gurney, H., Gebski, V., Harnett, P., Hui, R., Kefford, R., Wilcken, N., Ladekarl, M., von der Maase, H. & Donskov, F., 15 Aug 2013, In: Journal of Translational Medicine. 11, 8, 10 p., 189.

Advanced hepatocellular carcinoma in adolescence associated with congenital cholestasis: A case description

Ladekarl, M., Villadsen, G. E., Rudbeck, A. R., Aagenæs, Ø., Nielsen, J. E., Hamilton-Dutoit, S. & Nordsmark, M., 1 Jan 2013, In: Case Reports in Oncology. 6, 1, p. 98-103 6 p.

Diffuse abdominal splenosis mimicking peritoneal metastases in a 35-year-old man with a resectable carcinoma of the ampulla of vater

Sorensen, S. F., Mortensen, F. V., Hellberg, Y. & Ladekarl, M., 2013, In: Case Reports in Oncology. 6, 3, p. 467-71 5 p.

Sorafenib in advanced hepatocellular carcinoma: a nationwide retrospective study of efficacy and tolerability

Køstner, A. H., Sørensen, M., Olesen, R. K., Grønbæk, H., Lassen, U. & Ladekarl, M., 2013, In: Scientific World Journal. 2013, p. 931972

Sorafenib inhibits liver regeneration in rats

Andersen, K. J., Knudsen, A. R., Kannerup, A-S., Sasanuma, H., Nyengaard, J. R., Hamilton-Dutoit, S., Ladekarl, M. & Mortensen, F. V., 2013, In: H P B. 15, 12, p. 944-950 7 p.

Tumor-associated neutrophils and macrophages in non-small cell lung cancer: no immediate impact on patient outcome

Carus, A., Ladekarl, M., Hager, H., Pilegaard, H., Nielsen, P. S. & Donskov, F., 2013, In: Lung Cancer. 81, 1, p. 130-7 8 p.

Tumour-associated CD66b+ neutrophil count is an independent prognostic factor for recurrence in localised cervical cancer

Carus, A., Ladekarl, M., Hager, H., Nedergaard, B. & Donskov, F., 2013, In: B J C. 108, 10, p. 2116-22 7 p.

Dansk Pancreas Cancer Database

Fristrup, C., Palnæs Hansen, C., Ladekarl, M. & Mortensen, M. B., 2012, In: Ugeskrift for Læger. 174, 42, p. 2545 1 p.

Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers

Rohrberg, K. S., Olesen, R. K., Pfeiffer, P., Ladekarl, M., Pappot, H., Christensen, I. J., Høyer-Hansen, G., Sørensen, M., Skov, B. G., Buysschaert, I., Carmeliet, P. & Lassen, U., 2012, In: Acta Oncologica. Supplement. 51, 2, p. 234-42 9 p.

Malignant pheochromocytoma and paraganglioma: Three cases illustrating the use of molecular targeted diagnostics and therapy and possible role of new drugs

Zukauskaite, R., Hjorthgau, K., Poulsen, P. L., Baerentzen, S. & Ladekarl, M., 30 Jun 2011, In: Acta Oncologica. 50, 8, p. 1255-9 5 p.

Biomarkers in tissue from patients with upper gastrointestinal cancers treated with erlotinib and bevacizumab

Rohrberg, K. S., Pappot, H., Lassen, U., Westman, M., Olesen, R. K., Pfeiffer, P., Ladekarl, M., Sørensen, M., Christensen, I. J. & Skov, B. G., 2011, In: Cancer Biology & Therapy. 11, 8, p. 732-9 8 p.

Ovariemetastaser fra ventrikelcancer diagnosticeret med diffusionsvægtet 3T-magnetisk resonans-skanning

Røhl, L., Nellemann, H. M., Ladekarl, M. & Pedersen, E. M., 2011, In: Ugeskrift for Laeger. 173, 16-17, p. 1212-3 2 p.

Onkologisk behandling af patienter med pancreascancer

Ladekarl, M., Jensen, B. V. & Pfeiffer, P., 3 May 2010, In: Ugeskrift for Laeger. 172, 18, p. 1373-6 4 p.

A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years

Nedergaard, B., Ladekarl, M., Nyengaard, J. R. & Nielsen, K., 2008, In: Gynecologic Oncology. 108, 1, p. 106-111 6 p.

Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer

Nedergaard, B. S., Ladekarl, M., Thomsen, H. F., Nyengaard, J. R. & Nielsen, K., 2007, In: British Journal of Cancer. 97, 8, p. 1135-8 3 p.

Stereologic estimation of the total numbers, the composition and the anatomic distribution of lymphocytes in cone biopsies from patients with stage I squamous cell carcinoma of the cervix uteri

Nedergaard, B., Nielsen, K., Nyengaard, J. R. & Ladekarl, M., 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 12, p. 1321-30 9 p.

Detection of circulating tumour lysate-reactive CD4+ T cells in melanoma patients

Ladekarl, M., Agger, R., Fleischer, C. C., Hokland, M., Hulgaard, E. F., Kirkin, A., von der Maase, H., Petersen, M. S., Rytter, C., Zeuthen, J. & Gundersen, H. J. G., 2004, In: Cancer Immunology, Immunotherapy. 53, p. 560-566 7 p.

Measurements of hypoxia using pimonidazole and polarograhpic oxygen-sensitive electrodes in human cervix carcinomas

Nordsmark, M., Loncaster, J., Aquino-Parsons, C., Chou, S-C., Ladekarl, M., Havsteen, H., Lindegaard, J. C., Davidson, S. E., Varia, M., West, C., Hunter, R., Overgaard, J. & Raleigh, J. A., Apr 2003, In: Radiotherapy & Oncology. 67, 1, p. 35-44 10 p.

Nye behandlingsperspektiver ved duktalt carcinoma in situ mammae

Ladekarl, M., Grau, C. & Andersen, J., 10 Sept 2001, In: Ugeskrift for Laeger. 163, 37, p. 5014-7 4 p.

Nye behandlingsperspektiver ved duktalt carcinoma in situ mammae: New therapeutic perspectives in breast ductal carcinoma in situ

Ladekarl, M., Grau, C. & Andersen, J., 2001, In: Ugeskrift for Laeger. 163, 37, p. 5014-5017 4 p., 4979.

The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors

Horsman, M. R., Ehrnrooth, E., Ladekarl, M. & Overgaard, J., 1 Nov 1998, In: International Journal of Radiation Oncology, Biology, Physics. 42, 4, p. 895-898 4 p.

Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas

Jensen, V., Sørensen, F. B., Bentzen, S. M., Ladekarl, M., Nielsen, O. S., Keller, J. & Jensen, O. M., Jun 1998, In: Histopathology. 32, 6, p. 536-46 11 p.

The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer

Jensen, V., Ladekarl, M., Holm-Nielsen, P., Melsen, F. & Sørensen, F. B., Aug 1995, In: Journal of Pathology. 176, 4, p. 343-352 10 p.

Quantitative histopathological variables in in situ and invasive ductal and lobular carcinomas of the breast

Ladekarl, M. & Sørensen, F. B., Dec 1993, In: APMIS Supplementum. 101, 12, p. 895-903 9 p.

Prognostic, quantitative histopathologic variables in lobular carcinoma of the breast

Ladekarl, M. & Sørensen, F. B., 1 Nov 1993, In: Cancer. 72, 9, p. 2602-2611 10 p.

Prognostic value of nucleolar size and size pleomorphism in choroidal melanomas

Sørensen, F. B., Gamel, J. W., Jensen, O. A., Ladekarl, M. & McCurdy, J., May 1993, In: APMIS Supplementum. 101, 5, p. 358-368 11 p.