Morten Hesse

PERSONAL DATA

Date of Birth: 16 10 71

Birthplace: Copenhagen, Denmark

EDUCATION

2007 PhD in Psychology ‘Psychopathology and Addiction', Psychological Institute, University of Aarhus

PRESENT POSITION

2009 Associate professor at Centre for Alcohol and Drug Research, University of Aarhus

PAST PROFESSIONAL EXPERIENCE

Assistant professor at Centre for Alcohol and Drug Research, University of Aarhus PhD student at Centre for Alcohol and Drug Research, University of Aarhus

INTERNATIONAL RESEARCH CO-OPERATION

M. Fridell, professor, University of Lund, Sweden

E. Broekaert, professor, Department of Orthopedagogics, Ghent University, Belgium

P. Moran, Professor, Honorary Consultant Psychiatrist, Institute of Psychiatry, King's College, London, UK

NATIONAL RESEARCH CO-OPERATION

J. Lykke, Chief consultant psychiatrist, St. Hans Hospital, Roskilde

H. Thiesen, HealthTeam, Copenhagen City, Services for the Homeless

P. Nielsen, Ph.D., Ringgaarden Addiction Treatment Centre

E. Simonsen, Ph.D., Professor, Roskilde University

Editorial work

Associate editor with BMC Psychiatry (http://www.biomedcentral.com/bmcpsychiatry/edboard/) 2

Peer review

One or more articles reviewed since 2008 in the following peer reviewed journals:

Addiction

Addictive Behaviors

American Journal on Addictions

Archives of General Psychiatry

BMC Psychiatry

BMC Public Health

British Journal of Psychiatry

Drug and Alcohol Review

Journal of Affective Disorders

Journal of Personality Disorders

Journal of Sex Research

Scandinavian Journal of Public Health

Travel Medicine and Infectious Disease

Women and Health

And on one occasion for:

The Health Research Council of New Zealand

Research projects in which I have had a leading role:

Below are listed three projects in which I have taken a central and independent role in organizing data collection, selecting measures for the study, writing up the study, and - in the case of study 2 and 4 - designing and implementing the interventions being studied. However, a large part of my research work builds on the collaboration with partners inside and outside of the Centre for Alcohol and Drug Research.

1. Studying depression in patients receiving enhanced psychosocial treatment while undergoing opioid substitution treatment (1-3).

This was a part of my Ph.D., and was in itself part of a larger evaluation study of enhanced psychosocial services for substance use disorders. I was not principal investigator on this study, but I independently ran the following part of the study: For my Ph.D., data were collected on depression at baseline and 18 months follow-up, in order to study the long-term course of depression in subjects being treated for substance use disorders. Additionally, the so-called "readiness ruler" developed by S. Rollnick was tested as a predictor of outcome at 18 months follow-up.

2. Psychoeducation for personality disorders as an add-on to substance abuse treatment versus attention placebo: a controlled trial (4-7).

In the project, I compared personality disorder assessment and psychoeducation with an attention placebo intervention, and subjects were followed up at 3 and 6 months. The outcomes suggested a modest advantage for personality disorder assessment and psychoeducation in terms of the patients' substance use, but not in terms of functioning or psychiatric symptoms. The project was supported by a grant from Helsefonden (www.helsefonden.dk).

3. Case management for substance use disorders - in collaboration with University of Ghent, and Wright State University in Dayton, Ohio (8).

This was a review of case management for substance use disorders that was published by Cochrane Collaboration. The findings supported the effectiveness of case management in terms of linking subjects with services, and non-significant differences 4

favouring case management in terms of substance use. The study has received support from the Nordic Campbell Centre.

4. Enhanced treatments for substance use disorders and co-occurring disorders.

This project compares three different short-term interventions for substance use disorders and co-occurring disorders, and as such can be described as three studies in one. The study is conducted parallel in 6 different outpatient treatment units in Denmark. The project tests brief interventions for depression (based on Stacey Daughters' Let ACT model, 9), anxiety (based on a mindfulness-based and acceptance-based approach), and antisocial personality disorder (adapted from Glenn Walters' Lifestyle Issues model, 10, 11, 12). The project is ongoing. Randomization is closed as of August 2010. At this point, a total of 120 patients have been randomized, and of 58 assigned to experimental groups, 26 have so far begun treatment. The aim is to have 50 of the 58 begin treatment. The study has received support from "Helsefonden" and the Danish Ministry of Social Affairs (applicant: Mads Uffe Pedersen).

Research projects in which I have collaborated closely with others in the design and/or analysis of the project

1. Survey studies in Sunny Beach, Bulgaria, and at the Roskilde Festival, Denmark.

In a series of surveys conducted by the Centre for Alcohol and Drug Research in Sunny Beach, Bulgaria, I have supervised the design and development of the surveys, and conducted statistical analysis of data from the surveys, as well as drafted the manuscripts from several of the articles that have been written from these studies. These have been surveys of tourists' and visitors' use of drug and alcohol during their holiday. These include surveys conducted at the airport when subjects were leaving for home (13-15), a survey conducted along the pools (16, 17), and a prospective survey study, where subjects were asked to complete survey questionnaires several times during their holiday (18).

2. Quasi-experimental study of personality-informed treatment for alcohol dependence at Ringgaarden.

5

This study was a study carried out under the supervision of Per Nielsen, Ringgaarden. My role has been to help conduct statistical analyses after the data collection was completed, and to draft the manuscripts for the two peer-reviewed articles that have been published for this study, known in Denmark as project ALF (Alcohol and Life Focus) (19, 20).

3. Study of dual diagnosis patients at St. Hans Hospital.

The study of dual diagnosis patients at St. Hans Hospital was conceived by psychologist Stephen Austin and senior consultant Jørn Lykke. My role in this study was to conduct statistical analyses and draft the manuscript for two of the articles (21, 22).

4. Study of patients who were undergoing inpatient treatment for substance use disorders at St. Lars Hospital from 1978-1995.

This is a study that consists of a register-based study of the whole cohort of 1052 patients, and a follow-up study of a small sub-sample of 125 patients. My role in this study has been to conduct statistical analyses and to draft many of the articles from this study, including conceiving of some of the analyses conducted. The project has resulted in a number of publications (23-26).

5. Follow-up study of women who underwent compulsory care at Lunden, Sweden.

This is a follow-up study using both register data and interview data. My role in this study has been to conduct statistical analyses and to draft many of the articles from this study, including conceiving of some of the analyses conducted. The project has resulted in a number of publications (27-29).

Research project planned and funded

6. Safety problems in bars in Denmark.

The study is an assessment of selected bars from different areas in Denmark, focusing on risk factors for harm to patrons, including the physical environment, and staff and patron behaviour and attitudes. The study will employ a mixed methods approach using qualitative interviews of staff, managers and patrons, on-site observation, and a quantitative survey of patrons and staff. My role in this study will be as principal investigator. The study has received a grant from "Trygfonden". 6

Publications from research projects described above:

1. Hesse M. The Beck Depression Inventory in patients undergoing opiate agonist maintenance treatment. British Journal of Clinical Psychology. 2006 Sep;45(Pt 3):417-25.

2. Hesse M, Pedersen MU. Easy-access Services in Low-threshold Opiate Agonist Maintenance. International Journal of Mental Health and Addiction. 2008;6.

3. Hesse M. The readiness ruler as a measure of readiness to change poly-drug use in drug abusers. Harm Reduction Journal. 2006;3(3).

4. Hesse M. Course of self-reported symptoms of attention deficit and hyperactivity in substance abusers during early treatment. Addictive Behaviors. 2010;doi:10.1016/j.addbeh.2009.12.007.

5. Hesse M, Pedersen MK. Protocol: Personality assessment as a support for referral and case-work in treatment for substance use disorders (PASRC-study). BMC Psychiatry. 2008;8:30.

6. Hesse M. Psychoeducation for personality disorders as an add-on to substance abuse treatment versus attention placebo: a controlled trial. Drugs and Alcohol Today. 2010;10(1):25-32.

7. Hesse M, Moran P. Screening for personality disorder with the Standardised Assessment of Personality: Abbreviated Scale (SAPAS): further evidence of concurrent validity. BMC Psychiatry. 2010;10:10.

8. Hesse M, Vanderplasschen W, Rapp RC, Broekaert E, Fridell M. Case management for persons with substance use disorders. Cochrane Database of Systematic Reviews. 2007(4):CD006265.

9. Daughters SB, Braun AR, Sargeant MN, Reynolds EK, Hopko DR, Blanco C, et al. Effectiveness of a brief behavioral treatment for inner-city illicit drug users with elevated depressive symptoms: the life enhancement treatment for substance use (LETS Act!). Journal of Clinical Psychiatry. 2008 Jan;69(1):122-9.

10. Walters GD. The criminal lifestyle: Patterns of serious criminal conduct. Thousand Oaks, CA: Sage; 1990.

11. Elliott WN, Walters GD. Conducting psychoeducational interventions with drug abusing clients: the lifestyle model. Journal of Drug Education. 1997;27(3):307-19.

12. Walters GD. Recidivism in Released Lifestyle Change Program Participants Criminal Justice and Behavior. 2005;32(1):50-68.

13. Hesse M, Tutenges S, Schliewe S. The Use of Tobacco and Cannabis at an International Music Festival. European Addiction Research. 2010 Jul 2;16(4):208-12.

14. Hesse M, Tutenges S, Schliewe S, Reinholdt T. Party package travel: alcohol use and related problems in a holiday resort: a mixed methods study. BMC Public Health. 2008;8:351.

15. Tutenges S, Hesse M. Patterns of binge drinking at an international nightlife resort. Alcohol Alcohol. 2008 Sep-Oct;43(5):595-9.

16. Hesse M, Tutenges S. Gender differences in self-reported drinking-induced disinhibition of sexual behaviors. Am J Addict. 2008 Jul-Aug;17(4):293-7.

17. Hesse M, Tutenges S. Evening experiences versus drinking indicators as predictors of hangover on a summer holiday. Am J Addict. 2009 Mar-Apr;18(2):130-4.

18. Hesse M, Tutenges S. Predictors of hangover during a week of heavy drinking on holiday. Addiction. 2010 Mar;105(3):476-83.

19. Nielsen P, Rojskjaer S, Hesse M. Personality-guided treatment for alcohol dependence: a quasi-randomized experiment. American Journal on Addictions. 2007 Sep-Oct;16(5):357-64.

20. Hesse M, Nielsen P, Rojskjaer S. Stability and Change in Millon Clinical Multiaxial Inventory II Personality Disorder Scores in Treated Alcohol Dependent Subjects: Relationship to Post-treatment Abstinence. International Journal of Mental Health and Addiction. 2007;5:254-62. 7

21. Lykke J, Hesse M, Austin SF, Oestrich I. Validity of the BPRS, the BDI and the BAI in dual diagnosis patients. Addictive Behaviors. 2008 Feb;33(2):292-300.

22. Hesse M, Austin SF, Lykke J, Oestrich I. Predictors of completing treatment and achieving abstinence during inpatient dual diagnosis treatment. Mental Health and Substance Use: dual diagnosis. 2009;2(3):182-90.

23. Fridell M, Hesse M, Johnson E. High prognostic specificity of antisocial personality disorder in patients with drug dependence: results from a five-year follow-up. American Journal on Addictions. 2006 May-Jun;15(3):227-32.

24. Fridell M, Hesse M. Psychiatric severity and mortality in substance abusers: a 15-year follow-up of drug users. Addict Behav. 2006 Apr;31(4):559-65.

25. Fridell M, Hesse M, Billsten J. Criminal behavior in antisocial substance abusers between five and fifteen years follow-up. Am J Addict. 2007 Jan-Feb;16(1):10-4.

26. Fridell M, Hesse M, Jaeger MM, Kuhlhorn E. Antisocial personality disorder as a predictor of criminal behaviour in a longitudinal study of a cohort of abusers of several classes of drugs: relation to type of substance and type of crime. Addict Behav. 2008 Jun;33(6):799-811.

27. Jansson I, Hesse M, Fridell M. Personality disorder features as predictors of symptoms five years post-treatment. American Journal on Addictions. 2008 May-Jun;17(3):172-5.

28. Jansson I, Hesse M, Fridell M. Validity of self-reported criminal justice system involvement in substance abusing women at five-year follow-up. BMC Psychiatry. 2008;8:2.

29. Jansson I, Hesse M, Fridell M. Influence of personality disorder features on social functioning in substance-abusing women five years after compulsive residential treatment. European Addiction Research. 2009;15(1):25-31.

Morten Hesse

PERSONAL DATA

Date of Birth: 16 10 71

Birthplace: Copenhagen, Denmark

EDUCATION

2007 PhD in Psychology ‘Psychopathology and Addiction', Psychological Institute, University of Aarhus

PRESENT POSITION

2009 Associate professor at Centre for Alcohol and Drug Research, University of Aarhus

PAST PROFESSIONAL EXPERIENCE

Assistant professor at Centre for Alcohol and Drug Research, University of Aarhus PhD student at Centre for Alcohol and Drug Research, University of Aarhus

INTERNATIONAL RESEARCH CO-OPERATION

M. Fridell, professor, University of Lund, Sweden

E. Broekaert, professor, Department of Orthopedagogics, Ghent University, Belgium

P. Moran, Professor, Honorary Consultant Psychiatrist, Institute of Psychiatry, King's College, London, UK

NATIONAL RESEARCH CO-OPERATION

J. Lykke, Chief consultant psychiatrist, St. Hans Hospital, Roskilde

H. Thiesen, HealthTeam, Copenhagen City, Services for the Homeless

P. Nielsen, Ph.D., Ringgaarden Addiction Treatment Centre

E. Simonsen, Ph.D., Professor, Roskilde University

Editorial work

Associate editor with BMC Psychiatry (http://www.biomedcentral.com/bmcpsychiatry/edboard/) 2

Peer review

One or more articles reviewed since 2008 in the following peer reviewed journals:

Addiction

Addictive Behaviors

American Journal on Addictions

Archives of General Psychiatry

BMC Psychiatry

BMC Public Health

British Journal of Psychiatry

Drug and Alcohol Review

Journal of Affective Disorders

Journal of Personality Disorders

Journal of Sex Research

Scandinavian Journal of Public Health

Travel Medicine and Infectious Disease

Women and Health

And on one occasion for:

The Health Research Council of New Zealand

Research projects in which I have had a leading role:

Below are listed three projects in which I have taken a central and independent role in organizing data collection, selecting measures for the study, writing up the study, and - in the case of study 2 and 4 - designing and implementing the interventions being studied. However, a large part of my research work builds on the collaboration with partners inside and outside of the Centre for Alcohol and Drug Research.

1. Studying depression in patients receiving enhanced psychosocial treatment while undergoing opioid substitution treatment (1-3).

This was a part of my Ph.D., and was in itself part of a larger evaluation study of enhanced psychosocial services for substance use disorders. I was not principal investigator on this study, but I independently ran the following part of the study: For my Ph.D., data were collected on depression at baseline and 18 months follow-up, in order to study the long-term course of depression in subjects being treated for substance use disorders. Additionally, the so-called "readiness ruler" developed by S. Rollnick was tested as a predictor of outcome at 18 months follow-up.

2. Psychoeducation for personality disorders as an add-on to substance abuse treatment versus attention placebo: a controlled trial (4-7).

In the project, I compared personality disorder assessment and psychoeducation with an attention placebo intervention, and subjects were followed up at 3 and 6 months. The outcomes suggested a modest advantage for personality disorder assessment and psychoeducation in terms of the patients' substance use, but not in terms of functioning or psychiatric symptoms. The project was supported by a grant from Helsefonden (www.helsefonden.dk).

3. Case management for substance use disorders - in collaboration with University of Ghent, and Wright State University in Dayton, Ohio (8).

This was a review of case management for substance use disorders that was published by Cochrane Collaboration. The findings supported the effectiveness of case management in terms of linking subjects with services, and non-significant differences 4

favouring case management in terms of substance use. The study has received support from the Nordic Campbell Centre.

4. Enhanced treatments for substance use disorders and co-occurring disorders.

This project compares three different short-term interventions for substance use disorders and co-occurring disorders, and as such can be described as three studies in one. The study is conducted parallel in 6 different outpatient treatment units in Denmark. The project tests brief interventions for depression (based on Stacey Daughters' Let ACT model, 9), anxiety (based on a mindfulness-based and acceptance-based approach), and antisocial personality disorder (adapted from Glenn Walters' Lifestyle Issues model, 10, 11, 12). The project is ongoing. Randomization is closed as of August 2010. At this point, a total of 120 patients have been randomized, and of 58 assigned to experimental groups, 26 have so far begun treatment. The aim is to have 50 of the 58 begin treatment. The study has received support from "Helsefonden" and the Danish Ministry of Social Affairs (applicant: Mads Uffe Pedersen).

Research projects in which I have collaborated closely with others in the design and/or analysis of the project

1. Survey studies in Sunny Beach, Bulgaria, and at the Roskilde Festival, Denmark.

In a series of surveys conducted by the Centre for Alcohol and Drug Research in Sunny Beach, Bulgaria, I have supervised the design and development of the surveys, and conducted statistical analysis of data from the surveys, as well as drafted the manuscripts from several of the articles that have been written from these studies. These have been surveys of tourists' and visitors' use of drug and alcohol during their holiday. These include surveys conducted at the airport when subjects were leaving for home (13-15), a survey conducted along the pools (16, 17), and a prospective survey study, where subjects were asked to complete survey questionnaires several times during their holiday (18).

2. Quasi-experimental study of personality-informed treatment for alcohol dependence at Ringgaarden.

5

This study was a study carried out under the supervision of Per Nielsen, Ringgaarden. My role has been to help conduct statistical analyses after the data collection was completed, and to draft the manuscripts for the two peer-reviewed articles that have been published for this study, known in Denmark as project ALF (Alcohol and Life Focus) (19, 20).

3. Study of dual diagnosis patients at St. Hans Hospital.

The study of dual diagnosis patients at St. Hans Hospital was conceived by psychologist Stephen Austin and senior consultant Jørn Lykke. My role in this study was to conduct statistical analyses and draft the manuscript for two of the articles (21, 22).

4. Study of patients who were undergoing inpatient treatment for substance use disorders at St. Lars Hospital from 1978-1995.

This is a study that consists of a register-based study of the whole cohort of 1052 patients, and a follow-up study of a small sub-sample of 125 patients. My role in this study has been to conduct statistical analyses and to draft many of the articles from this study, including conceiving of some of the analyses conducted. The project has resulted in a number of publications (23-26).

5. Follow-up study of women who underwent compulsory care at Lunden, Sweden.

This is a follow-up study using both register data and interview data. My role in this study has been to conduct statistical analyses and to draft many of the articles from this study, including conceiving of some of the analyses conducted. The project has resulted in a number of publications (27-29).

Research project planned and funded

6. Safety problems in bars in Denmark.

The study is an assessment of selected bars from different areas in Denmark, focusing on risk factors for harm to patrons, including the physical environment, and staff and patron behaviour and attitudes. The study will employ a mixed methods approach using qualitative interviews of staff, managers and patrons, on-site observation, and a quantitative survey of patrons and staff. My role in this study will be as principal investigator. The study has received a grant from "Trygfonden". 6

Publications from research projects described above:

1. Hesse M. The Beck Depression Inventory in patients undergoing opiate agonist maintenance treatment. British Journal of Clinical Psychology. 2006 Sep;45(Pt 3):417-25.

2. Hesse M, Pedersen MU. Easy-access Services in Low-threshold Opiate Agonist Maintenance. International Journal of Mental Health and Addiction. 2008;6.

3. Hesse M. The readiness ruler as a measure of readiness to change poly-drug use in drug abusers. Harm Reduction Journal. 2006;3(3).

4. Hesse M. Course of self-reported symptoms of attention deficit and hyperactivity in substance abusers during early treatment. Addictive Behaviors. 2010;doi:10.1016/j.addbeh.2009.12.007.

5. Hesse M, Pedersen MK. Protocol: Personality assessment as a support for referral and case-work in treatment for substance use disorders (PASRC-study). BMC Psychiatry. 2008;8:30.

6. Hesse M. Psychoeducation for personality disorders as an add-on to substance abuse treatment versus attention placebo: a controlled trial. Drugs and Alcohol Today. 2010;10(1):25-32.

7. Hesse M, Moran P. Screening for personality disorder with the Standardised Assessment of Personality: Abbreviated Scale (SAPAS): further evidence of concurrent validity. BMC Psychiatry. 2010;10:10.

8. Hesse M, Vanderplasschen W, Rapp RC, Broekaert E, Fridell M. Case management for persons with substance use disorders. Cochrane Database of Systematic Reviews. 2007(4):CD006265.

9. Daughters SB, Braun AR, Sargeant MN, Reynolds EK, Hopko DR, Blanco C, et al. Effectiveness of a brief behavioral treatment for inner-city illicit drug users with elevated depressive symptoms: the life enhancement treatment for substance use (LETS Act!). Journal of Clinical Psychiatry. 2008 Jan;69(1):122-9.

10. Walters GD. The criminal lifestyle: Patterns of serious criminal conduct. Thousand Oaks, CA: Sage; 1990.

11. Elliott WN, Walters GD. Conducting psychoeducational interventions with drug abusing clients: the lifestyle model. Journal of Drug Education. 1997;27(3):307-19.

12. Walters GD. Recidivism in Released Lifestyle Change Program Participants Criminal Justice and Behavior. 2005;32(1):50-68.

13. Hesse M, Tutenges S, Schliewe S. The Use of Tobacco and Cannabis at an International Music Festival. European Addiction Research. 2010 Jul 2;16(4):208-12.

14. Hesse M, Tutenges S, Schliewe S, Reinholdt T. Party package travel: alcohol use and related problems in a holiday resort: a mixed methods study. BMC Public Health. 2008;8:351.

15. Tutenges S, Hesse M. Patterns of binge drinking at an international nightlife resort. Alcohol Alcohol. 2008 Sep-Oct;43(5):595-9.

16. Hesse M, Tutenges S. Gender differences in self-reported drinking-induced disinhibition of sexual behaviors. Am J Addict. 2008 Jul-Aug;17(4):293-7.

17. Hesse M, Tutenges S. Evening experiences versus drinking indicators as predictors of hangover on a summer holiday. Am J Addict. 2009 Mar-Apr;18(2):130-4.

18. Hesse M, Tutenges S. Predictors of hangover during a week of heavy drinking on holiday. Addiction. 2010 Mar;105(3):476-83.

19. Nielsen P, Rojskjaer S, Hesse M. Personality-guided treatment for alcohol dependence: a quasi-randomized experiment. American Journal on Addictions. 2007 Sep-Oct;16(5):357-64.

20. Hesse M, Nielsen P, Rojskjaer S. Stability and Change in Millon Clinical Multiaxial Inventory II Personality Disorder Scores in Treated Alcohol Dependent Subjects: Relationship to Post-treatment Abstinence. International Journal of Mental Health and Addiction. 2007;5:254-62. 7

21. Lykke J, Hesse M, Austin SF, Oestrich I. Validity of the BPRS, the BDI and the BAI in dual diagnosis patients. Addictive Behaviors. 2008 Feb;33(2):292-300.

22. Hesse M, Austin SF, Lykke J, Oestrich I. Predictors of completing treatment and achieving abstinence during inpatient dual diagnosis treatment. Mental Health and Substance Use: dual diagnosis. 2009;2(3):182-90.

23. Fridell M, Hesse M, Johnson E. High prognostic specificity of antisocial personality disorder in patients with drug dependence: results from a five-year follow-up. American Journal on Addictions. 2006 May-Jun;15(3):227-32.

24. Fridell M, Hesse M. Psychiatric severity and mortality in substance abusers: a 15-year follow-up of drug users. Addict Behav. 2006 Apr;31(4):559-65.

25. Fridell M, Hesse M, Billsten J. Criminal behavior in antisocial substance abusers between five and fifteen years follow-up. Am J Addict. 2007 Jan-Feb;16(1):10-4.

26. Fridell M, Hesse M, Jaeger MM, Kuhlhorn E. Antisocial personality disorder as a predictor of criminal behaviour in a longitudinal study of a cohort of abusers of several classes of drugs: relation to type of substance and type of crime. Addict Behav. 2008 Jun;33(6):799-811.

27. Jansson I, Hesse M, Fridell M. Personality disorder features as predictors of symptoms five years post-treatment. American Journal on Addictions. 2008 May-Jun;17(3):172-5.

28. Jansson I, Hesse M, Fridell M. Validity of self-reported criminal justice system involvement in substance abusing women at five-year follow-up. BMC Psychiatry. 2008;8:2.

29. Jansson I, Hesse M, Fridell M. Influence of personality disorder features on social functioning in substance-abusing women five years after compulsive residential treatment. European Addiction Research. 2009;15(1):25-31.